Oxidative stress biomarkers are associated with visible clinical signs of a disease in frigatebird nestlings

Abstract Infectious diseases are one of the most common threats for both domestic and wild animals, but little is known about the effects on the physiological condition and survival of wild animals. Here, we have tested for the first time in a wild vertebrate facing a viral disease possibly due to h...

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Autores principales:	Manrico Sebastiano, Marcel Eens, Hamada Abd Elgawad, Benoît de Thoisy, Vincent Lacoste, Kévin Pineau, Han Asard, Olivier Chastel, David Costantini
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/253781d7dc504210982801ae8b5dda9a
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spelling	oai:doaj.org-article:253781d7dc504210982801ae8b5dda9a2021-12-02T16:06:00ZOxidative stress biomarkers are associated with visible clinical signs of a disease in frigatebird nestlings10.1038/s41598-017-01417-92045-2322https://doaj.org/article/253781d7dc504210982801ae8b5dda9a2017-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-01417-9https://doaj.org/toc/2045-2322Abstract Infectious diseases are one of the most common threats for both domestic and wild animals, but little is known about the effects on the physiological condition and survival of wild animals. Here, we have tested for the first time in a wild vertebrate facing a viral disease possibly due to herpesvirus (i) whether nestlings with either low levels of oxidative damage or high levels of antioxidant protection are less susceptible to develop visible clinical signs, (ii) whether the disease is associated with the nestlings’ oxidative status, (iii) whether the association between the disease and oxidative status is similar between males and females (iv), and whether cloacal and tracheal swabs might be used to detect herpesvirus. To address our questions, we took advantage of a population of Magnificent frigatebirds (Fregata magnificens) whose nestlings have experienced high mortality rates in recent times. Our work shows that (i) blood lipid oxidative damage is associated with observable clinical signs and survival probabilities of nestling frigatebirds, and (ii) that high glutathione levels in red blood cells are associated with the emergence of visible clinical signs of the disease. Our work provides evidence that differences in the oxidative status of nestlings might underlie individual health and survival.Manrico SebastianoMarcel EensHamada Abd ElgawadBenoît de ThoisyVincent LacosteKévin PineauHan AsardOlivier ChastelDavid CostantiniNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Manrico Sebastiano Marcel Eens Hamada Abd Elgawad Benoît de Thoisy Vincent Lacoste Kévin Pineau Han Asard Olivier Chastel David Costantini Oxidative stress biomarkers are associated with visible clinical signs of a disease in frigatebird nestlings
description	Abstract Infectious diseases are one of the most common threats for both domestic and wild animals, but little is known about the effects on the physiological condition and survival of wild animals. Here, we have tested for the first time in a wild vertebrate facing a viral disease possibly due to herpesvirus (i) whether nestlings with either low levels of oxidative damage or high levels of antioxidant protection are less susceptible to develop visible clinical signs, (ii) whether the disease is associated with the nestlings’ oxidative status, (iii) whether the association between the disease and oxidative status is similar between males and females (iv), and whether cloacal and tracheal swabs might be used to detect herpesvirus. To address our questions, we took advantage of a population of Magnificent frigatebirds (Fregata magnificens) whose nestlings have experienced high mortality rates in recent times. Our work shows that (i) blood lipid oxidative damage is associated with observable clinical signs and survival probabilities of nestling frigatebirds, and (ii) that high glutathione levels in red blood cells are associated with the emergence of visible clinical signs of the disease. Our work provides evidence that differences in the oxidative status of nestlings might underlie individual health and survival.
format	article
author	Manrico Sebastiano Marcel Eens Hamada Abd Elgawad Benoît de Thoisy Vincent Lacoste Kévin Pineau Han Asard Olivier Chastel David Costantini
author_facet	Manrico Sebastiano Marcel Eens Hamada Abd Elgawad Benoît de Thoisy Vincent Lacoste Kévin Pineau Han Asard Olivier Chastel David Costantini
author_sort	Manrico Sebastiano
title	Oxidative stress biomarkers are associated with visible clinical signs of a disease in frigatebird nestlings
title_short	Oxidative stress biomarkers are associated with visible clinical signs of a disease in frigatebird nestlings
title_full	Oxidative stress biomarkers are associated with visible clinical signs of a disease in frigatebird nestlings
title_fullStr	Oxidative stress biomarkers are associated with visible clinical signs of a disease in frigatebird nestlings
title_full_unstemmed	Oxidative stress biomarkers are associated with visible clinical signs of a disease in frigatebird nestlings
title_sort	oxidative stress biomarkers are associated with visible clinical signs of a disease in frigatebird nestlings
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/253781d7dc504210982801ae8b5dda9a
work_keys_str_mv	AT manricosebastiano oxidativestressbiomarkersareassociatedwithvisibleclinicalsignsofadiseaseinfrigatebirdnestlings AT marceleens oxidativestressbiomarkersareassociatedwithvisibleclinicalsignsofadiseaseinfrigatebirdnestlings AT hamadaabdelgawad oxidativestressbiomarkersareassociatedwithvisibleclinicalsignsofadiseaseinfrigatebirdnestlings AT benoitdethoisy oxidativestressbiomarkersareassociatedwithvisibleclinicalsignsofadiseaseinfrigatebirdnestlings AT vincentlacoste oxidativestressbiomarkersareassociatedwithvisibleclinicalsignsofadiseaseinfrigatebirdnestlings AT kevinpineau oxidativestressbiomarkersareassociatedwithvisibleclinicalsignsofadiseaseinfrigatebirdnestlings AT hanasard oxidativestressbiomarkersareassociatedwithvisibleclinicalsignsofadiseaseinfrigatebirdnestlings AT olivierchastel oxidativestressbiomarkersareassociatedwithvisibleclinicalsignsofadiseaseinfrigatebirdnestlings AT davidcostantini oxidativestressbiomarkersareassociatedwithvisibleclinicalsignsofadiseaseinfrigatebirdnestlings
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Oxidative stress biomarkers are associated with visible clinical signs of a disease in frigatebird nestlings

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