Incidence of cardiovascular events and mortality in Korean patients with chronic kidney disease

Abstract Few studies have investigated the incidence of cardiovascular disease (CVD) in the Asian chronic kidney disease (CKD) population. This study assessed the incidence of CVD, death, and a composite outcome of CVD and death in a prospective Korean predialysis CKD cohort. From a total of 2179 pa...

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Autores principales:	Hyunjin Ryu, Jayoun Kim, Eunjeong Kang, Yeji Hong, Dong-Wan Chae, Kyu Hun Choi, Seung Hyeok Han, Tae Hyun Yoo, Kyubeck Lee, Yong-Soo Kim, Wookyung Chung, Yun Kyu Oh, Soo Wan Kim, Yeong Hoon Kim, Su Ah Sung, Joongyub Lee, Sue K. Park, Curie Ahn, Kook-Hwan Oh, Representing KNOW-CKD Study Group
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/2539435d1c0241568d54550573f258db
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spelling	oai:doaj.org-article:2539435d1c0241568d54550573f258db2021-12-02T14:12:47ZIncidence of cardiovascular events and mortality in Korean patients with chronic kidney disease10.1038/s41598-020-80877-y2045-2322https://doaj.org/article/2539435d1c0241568d54550573f258db2021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-80877-yhttps://doaj.org/toc/2045-2322Abstract Few studies have investigated the incidence of cardiovascular disease (CVD) in the Asian chronic kidney disease (CKD) population. This study assessed the incidence of CVD, death, and a composite outcome of CVD and death in a prospective Korean predialysis CKD cohort. From a total of 2179 patients, incidence rates were analyzed, and competing risk analyses were conducted according to CKD stage. Additionally, incidence was compared to the general population. During a median 4.1 years of follow-up, the incidence of CVD, all-cause death, and the composite outcome was 17.2, 9.6, and 24.5 per 1000 person-years, respectively. These values were higher in diabetic vs. non-diabetic subjects (P < 0.001). For all outcomes, incidence rates increased with increasing CKD stage (CVD, P = 0.001; death, P < 0.001; and composite, P < 0.001). Additionally, CKD stage G4 [hazard ratio (HR) 2.8, P = 0.008] and G5 (HR 5.0, P < 0.001) were significant risk factors for the composite outcome compared to stage G1 after adjustment. Compared to the general population, the total cohort population (stages G1–G5) showed significantly higher risk of CVD (HR 2.4, P < 0.001) and the composite outcome (HR 1.7, P < 0.001). The results clearly demonstrate that CKD is a risk factor for CVD in an Asian population.Hyunjin RyuJayoun KimEunjeong KangYeji HongDong-Wan ChaeKyu Hun ChoiSeung Hyeok HanTae Hyun YooKyubeck LeeYong-Soo KimWookyung ChungYun Kyu OhSoo Wan KimYeong Hoon KimSu Ah SungJoongyub LeeSue K. ParkCurie AhnKook-Hwan OhRepresenting KNOW-CKD Study GroupNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Hyunjin Ryu Jayoun Kim Eunjeong Kang Yeji Hong Dong-Wan Chae Kyu Hun Choi Seung Hyeok Han Tae Hyun Yoo Kyubeck Lee Yong-Soo Kim Wookyung Chung Yun Kyu Oh Soo Wan Kim Yeong Hoon Kim Su Ah Sung Joongyub Lee Sue K. Park Curie Ahn Kook-Hwan Oh Representing KNOW-CKD Study Group Incidence of cardiovascular events and mortality in Korean patients with chronic kidney disease
description	Abstract Few studies have investigated the incidence of cardiovascular disease (CVD) in the Asian chronic kidney disease (CKD) population. This study assessed the incidence of CVD, death, and a composite outcome of CVD and death in a prospective Korean predialysis CKD cohort. From a total of 2179 patients, incidence rates were analyzed, and competing risk analyses were conducted according to CKD stage. Additionally, incidence was compared to the general population. During a median 4.1 years of follow-up, the incidence of CVD, all-cause death, and the composite outcome was 17.2, 9.6, and 24.5 per 1000 person-years, respectively. These values were higher in diabetic vs. non-diabetic subjects (P < 0.001). For all outcomes, incidence rates increased with increasing CKD stage (CVD, P = 0.001; death, P < 0.001; and composite, P < 0.001). Additionally, CKD stage G4 [hazard ratio (HR) 2.8, P = 0.008] and G5 (HR 5.0, P < 0.001) were significant risk factors for the composite outcome compared to stage G1 after adjustment. Compared to the general population, the total cohort population (stages G1–G5) showed significantly higher risk of CVD (HR 2.4, P < 0.001) and the composite outcome (HR 1.7, P < 0.001). The results clearly demonstrate that CKD is a risk factor for CVD in an Asian population.
format	article
author	Hyunjin Ryu Jayoun Kim Eunjeong Kang Yeji Hong Dong-Wan Chae Kyu Hun Choi Seung Hyeok Han Tae Hyun Yoo Kyubeck Lee Yong-Soo Kim Wookyung Chung Yun Kyu Oh Soo Wan Kim Yeong Hoon Kim Su Ah Sung Joongyub Lee Sue K. Park Curie Ahn Kook-Hwan Oh Representing KNOW-CKD Study Group
author_facet	Hyunjin Ryu Jayoun Kim Eunjeong Kang Yeji Hong Dong-Wan Chae Kyu Hun Choi Seung Hyeok Han Tae Hyun Yoo Kyubeck Lee Yong-Soo Kim Wookyung Chung Yun Kyu Oh Soo Wan Kim Yeong Hoon Kim Su Ah Sung Joongyub Lee Sue K. Park Curie Ahn Kook-Hwan Oh Representing KNOW-CKD Study Group
author_sort	Hyunjin Ryu
title	Incidence of cardiovascular events and mortality in Korean patients with chronic kidney disease
title_short	Incidence of cardiovascular events and mortality in Korean patients with chronic kidney disease
title_full	Incidence of cardiovascular events and mortality in Korean patients with chronic kidney disease
title_fullStr	Incidence of cardiovascular events and mortality in Korean patients with chronic kidney disease
title_full_unstemmed	Incidence of cardiovascular events and mortality in Korean patients with chronic kidney disease
title_sort	incidence of cardiovascular events and mortality in korean patients with chronic kidney disease
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/2539435d1c0241568d54550573f258db
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Incidence of cardiovascular events and mortality in Korean patients with chronic kidney disease

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