Neurocognitive status and risk of mortality among people living with human immunodeficiency virus: an 18-year retrospective cohort study

Abstract HIV-related neurocognitive impairment (NCI) may increase the risk of death. However, a survival disadvantage for patients with NCI has not been well studied in the post-combination antiretroviral therapy (cART) era. Specifically, limited research has been conducted considering the reversibl...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Zaeema Naveed, Howard S. Fox, Christopher S. Wichman, Morshed Alam, Pamela May, Christine M. Arcari, Jane Meza, Steven Totusek, Lorena Baccaglini
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/253c3d8a650448729dcff24a747c17af
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:253c3d8a650448729dcff24a747c17af
record_format	dspace
spelling	oai:doaj.org-article:253c3d8a650448729dcff24a747c17af2021-12-02T12:09:26ZNeurocognitive status and risk of mortality among people living with human immunodeficiency virus: an 18-year retrospective cohort study10.1038/s41598-021-83131-12045-2322https://doaj.org/article/253c3d8a650448729dcff24a747c17af2021-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-83131-1https://doaj.org/toc/2045-2322Abstract HIV-related neurocognitive impairment (NCI) may increase the risk of death. However, a survival disadvantage for patients with NCI has not been well studied in the post-combination antiretroviral therapy (cART) era. Specifically, limited research has been conducted considering the reversible nature and variable progression of the impairment and this area demands further evaluation. We performed multivariable Cox proportional hazards modeling to assess the association between baseline NCI (global T scores) and mortality. A joint modeling approach was then used to model the trajectory of global neurocognitive functioning over time and the association between neurocognitive trajectory and mortality. Among the National NeuroAIDS Tissue Consortium’s (NNTC) HIV-infected participants, we found a strong negative association between NCI and mortality in the older age groups (e.g., at age = 55, HR = 0.79; 95% CI 0.64–0.99). Three neurocognitive sub-domains (abstraction and executive functioning, speed of information processing, and motor) had the strongest negative association with mortality. Joint modelling indicated a 33% lower hazard for every 10-unit increase in global T scores (HR = 0.67; 95% CI 0.56–0.80). The study identified older HIV-infected individuals with NCI as a group needing special attention for the longevity of life. The study has considerable prognostic utility by not only predicting mortality hazard, but also future cognitive status.Zaeema NaveedHoward S. FoxChristopher S. WichmanMorshed AlamPamela MayChristine M. ArcariJane MezaSteven TotusekLorena BaccagliniNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Zaeema Naveed Howard S. Fox Christopher S. Wichman Morshed Alam Pamela May Christine M. Arcari Jane Meza Steven Totusek Lorena Baccaglini Neurocognitive status and risk of mortality among people living with human immunodeficiency virus: an 18-year retrospective cohort study
description	Abstract HIV-related neurocognitive impairment (NCI) may increase the risk of death. However, a survival disadvantage for patients with NCI has not been well studied in the post-combination antiretroviral therapy (cART) era. Specifically, limited research has been conducted considering the reversible nature and variable progression of the impairment and this area demands further evaluation. We performed multivariable Cox proportional hazards modeling to assess the association between baseline NCI (global T scores) and mortality. A joint modeling approach was then used to model the trajectory of global neurocognitive functioning over time and the association between neurocognitive trajectory and mortality. Among the National NeuroAIDS Tissue Consortium’s (NNTC) HIV-infected participants, we found a strong negative association between NCI and mortality in the older age groups (e.g., at age = 55, HR = 0.79; 95% CI 0.64–0.99). Three neurocognitive sub-domains (abstraction and executive functioning, speed of information processing, and motor) had the strongest negative association with mortality. Joint modelling indicated a 33% lower hazard for every 10-unit increase in global T scores (HR = 0.67; 95% CI 0.56–0.80). The study identified older HIV-infected individuals with NCI as a group needing special attention for the longevity of life. The study has considerable prognostic utility by not only predicting mortality hazard, but also future cognitive status.
format	article
author	Zaeema Naveed Howard S. Fox Christopher S. Wichman Morshed Alam Pamela May Christine M. Arcari Jane Meza Steven Totusek Lorena Baccaglini
author_facet	Zaeema Naveed Howard S. Fox Christopher S. Wichman Morshed Alam Pamela May Christine M. Arcari Jane Meza Steven Totusek Lorena Baccaglini
author_sort	Zaeema Naveed
title	Neurocognitive status and risk of mortality among people living with human immunodeficiency virus: an 18-year retrospective cohort study
title_short	Neurocognitive status and risk of mortality among people living with human immunodeficiency virus: an 18-year retrospective cohort study
title_full	Neurocognitive status and risk of mortality among people living with human immunodeficiency virus: an 18-year retrospective cohort study
title_fullStr	Neurocognitive status and risk of mortality among people living with human immunodeficiency virus: an 18-year retrospective cohort study
title_full_unstemmed	Neurocognitive status and risk of mortality among people living with human immunodeficiency virus: an 18-year retrospective cohort study
title_sort	neurocognitive status and risk of mortality among people living with human immunodeficiency virus: an 18-year retrospective cohort study
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/253c3d8a650448729dcff24a747c17af
work_keys_str_mv	AT zaeemanaveed neurocognitivestatusandriskofmortalityamongpeoplelivingwithhumanimmunodeficiencyvirusan18yearretrospectivecohortstudy AT howardsfox neurocognitivestatusandriskofmortalityamongpeoplelivingwithhumanimmunodeficiencyvirusan18yearretrospectivecohortstudy AT christopherswichman neurocognitivestatusandriskofmortalityamongpeoplelivingwithhumanimmunodeficiencyvirusan18yearretrospectivecohortstudy AT morshedalam neurocognitivestatusandriskofmortalityamongpeoplelivingwithhumanimmunodeficiencyvirusan18yearretrospectivecohortstudy AT pamelamay neurocognitivestatusandriskofmortalityamongpeoplelivingwithhumanimmunodeficiencyvirusan18yearretrospectivecohortstudy AT christinemarcari neurocognitivestatusandriskofmortalityamongpeoplelivingwithhumanimmunodeficiencyvirusan18yearretrospectivecohortstudy AT janemeza neurocognitivestatusandriskofmortalityamongpeoplelivingwithhumanimmunodeficiencyvirusan18yearretrospectivecohortstudy AT steventotusek neurocognitivestatusandriskofmortalityamongpeoplelivingwithhumanimmunodeficiencyvirusan18yearretrospectivecohortstudy AT lorenabaccaglini neurocognitivestatusandriskofmortalityamongpeoplelivingwithhumanimmunodeficiencyvirusan18yearretrospectivecohortstudy
_version_	1718394616978341888

Neurocognitive status and risk of mortality among people living with human immunodeficiency virus: an 18-year retrospective cohort study

Ejemplares similares