Aberrant DNA Methylation Mediates the Transgenerational Risk of Metabolic and Chronic Disease Due to Maternal Obesity and Overnutrition

Maternal obesity is a rapidly evolving universal epidemic leading to acute and long-term medical and obstetric health issues, including increased maternal risks of gestational diabetes, hypertension and pre-eclampsia, and the future risks for offspring’s predisposition to metabolic diseases. Epigene...

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Autores principales: Yan Li, Carol A. Pollock, Sonia Saad
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Lenguaje:EN
Publicado: MDPI AG 2021
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Acceso en línea:https://doaj.org/article/253c9a1e870c4951879a05bd406c7537
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spelling oai:doaj.org-article:253c9a1e870c4951879a05bd406c75372021-11-25T17:40:16ZAberrant DNA Methylation Mediates the Transgenerational Risk of Metabolic and Chronic Disease Due to Maternal Obesity and Overnutrition10.3390/genes121116532073-4425https://doaj.org/article/253c9a1e870c4951879a05bd406c75372021-10-01T00:00:00Zhttps://www.mdpi.com/2073-4425/12/11/1653https://doaj.org/toc/2073-4425Maternal obesity is a rapidly evolving universal epidemic leading to acute and long-term medical and obstetric health issues, including increased maternal risks of gestational diabetes, hypertension and pre-eclampsia, and the future risks for offspring’s predisposition to metabolic diseases. Epigenetic modification, in particular DNA methylation, represents a mechanism whereby environmental effects impact on the phenotypic expression of human disease. Maternal obesity or overnutrition contributes to the alterations in DNA methylation during early life which, through fetal programming, can predispose the offspring to many metabolic and chronic diseases, such as non-alcoholic fatty liver disease, obesity, diabetes, and chronic kidney disease. This review aims to summarize findings from human and animal studies, which support the role of maternal obesity in fetal programing and the potential benefit of altering DNA methylation to limit maternal obesity related disease in the offspring.Yan LiCarol A. PollockSonia SaadMDPI AGarticleDNA methylationmaternal obesityovernutritionmetabolic diseasesoffspringGeneticsQH426-470ENGenes, Vol 12, Iss 1653, p 1653 (2021)
institution DOAJ
collection DOAJ
language EN
topic DNA methylation
maternal obesity
overnutrition
metabolic diseases
offspring
Genetics
QH426-470
spellingShingle DNA methylation
maternal obesity
overnutrition
metabolic diseases
offspring
Genetics
QH426-470
Yan Li
Carol A. Pollock
Sonia Saad
Aberrant DNA Methylation Mediates the Transgenerational Risk of Metabolic and Chronic Disease Due to Maternal Obesity and Overnutrition
description Maternal obesity is a rapidly evolving universal epidemic leading to acute and long-term medical and obstetric health issues, including increased maternal risks of gestational diabetes, hypertension and pre-eclampsia, and the future risks for offspring’s predisposition to metabolic diseases. Epigenetic modification, in particular DNA methylation, represents a mechanism whereby environmental effects impact on the phenotypic expression of human disease. Maternal obesity or overnutrition contributes to the alterations in DNA methylation during early life which, through fetal programming, can predispose the offspring to many metabolic and chronic diseases, such as non-alcoholic fatty liver disease, obesity, diabetes, and chronic kidney disease. This review aims to summarize findings from human and animal studies, which support the role of maternal obesity in fetal programing and the potential benefit of altering DNA methylation to limit maternal obesity related disease in the offspring.
format article
author Yan Li
Carol A. Pollock
Sonia Saad
author_facet Yan Li
Carol A. Pollock
Sonia Saad
author_sort Yan Li
title Aberrant DNA Methylation Mediates the Transgenerational Risk of Metabolic and Chronic Disease Due to Maternal Obesity and Overnutrition
title_short Aberrant DNA Methylation Mediates the Transgenerational Risk of Metabolic and Chronic Disease Due to Maternal Obesity and Overnutrition
title_full Aberrant DNA Methylation Mediates the Transgenerational Risk of Metabolic and Chronic Disease Due to Maternal Obesity and Overnutrition
title_fullStr Aberrant DNA Methylation Mediates the Transgenerational Risk of Metabolic and Chronic Disease Due to Maternal Obesity and Overnutrition
title_full_unstemmed Aberrant DNA Methylation Mediates the Transgenerational Risk of Metabolic and Chronic Disease Due to Maternal Obesity and Overnutrition
title_sort aberrant dna methylation mediates the transgenerational risk of metabolic and chronic disease due to maternal obesity and overnutrition
publisher MDPI AG
publishDate 2021
url https://doaj.org/article/253c9a1e870c4951879a05bd406c7537
work_keys_str_mv AT yanli aberrantdnamethylationmediatesthetransgenerationalriskofmetabolicandchronicdiseaseduetomaternalobesityandovernutrition
AT carolapollock aberrantdnamethylationmediatesthetransgenerationalriskofmetabolicandchronicdiseaseduetomaternalobesityandovernutrition
AT soniasaad aberrantdnamethylationmediatesthetransgenerationalriskofmetabolicandchronicdiseaseduetomaternalobesityandovernutrition
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