Aberrant DNA Methylation Mediates the Transgenerational Risk of Metabolic and Chronic Disease Due to Maternal Obesity and Overnutrition
Maternal obesity is a rapidly evolving universal epidemic leading to acute and long-term medical and obstetric health issues, including increased maternal risks of gestational diabetes, hypertension and pre-eclampsia, and the future risks for offspring’s predisposition to metabolic diseases. Epigene...
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2021
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oai:doaj.org-article:253c9a1e870c4951879a05bd406c75372021-11-25T17:40:16ZAberrant DNA Methylation Mediates the Transgenerational Risk of Metabolic and Chronic Disease Due to Maternal Obesity and Overnutrition10.3390/genes121116532073-4425https://doaj.org/article/253c9a1e870c4951879a05bd406c75372021-10-01T00:00:00Zhttps://www.mdpi.com/2073-4425/12/11/1653https://doaj.org/toc/2073-4425Maternal obesity is a rapidly evolving universal epidemic leading to acute and long-term medical and obstetric health issues, including increased maternal risks of gestational diabetes, hypertension and pre-eclampsia, and the future risks for offspring’s predisposition to metabolic diseases. Epigenetic modification, in particular DNA methylation, represents a mechanism whereby environmental effects impact on the phenotypic expression of human disease. Maternal obesity or overnutrition contributes to the alterations in DNA methylation during early life which, through fetal programming, can predispose the offspring to many metabolic and chronic diseases, such as non-alcoholic fatty liver disease, obesity, diabetes, and chronic kidney disease. This review aims to summarize findings from human and animal studies, which support the role of maternal obesity in fetal programing and the potential benefit of altering DNA methylation to limit maternal obesity related disease in the offspring.Yan LiCarol A. PollockSonia SaadMDPI AGarticleDNA methylationmaternal obesityovernutritionmetabolic diseasesoffspringGeneticsQH426-470ENGenes, Vol 12, Iss 1653, p 1653 (2021) |
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DNA methylation maternal obesity overnutrition metabolic diseases offspring Genetics QH426-470 |
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DNA methylation maternal obesity overnutrition metabolic diseases offspring Genetics QH426-470 Yan Li Carol A. Pollock Sonia Saad Aberrant DNA Methylation Mediates the Transgenerational Risk of Metabolic and Chronic Disease Due to Maternal Obesity and Overnutrition |
description |
Maternal obesity is a rapidly evolving universal epidemic leading to acute and long-term medical and obstetric health issues, including increased maternal risks of gestational diabetes, hypertension and pre-eclampsia, and the future risks for offspring’s predisposition to metabolic diseases. Epigenetic modification, in particular DNA methylation, represents a mechanism whereby environmental effects impact on the phenotypic expression of human disease. Maternal obesity or overnutrition contributes to the alterations in DNA methylation during early life which, through fetal programming, can predispose the offspring to many metabolic and chronic diseases, such as non-alcoholic fatty liver disease, obesity, diabetes, and chronic kidney disease. This review aims to summarize findings from human and animal studies, which support the role of maternal obesity in fetal programing and the potential benefit of altering DNA methylation to limit maternal obesity related disease in the offspring. |
format |
article |
author |
Yan Li Carol A. Pollock Sonia Saad |
author_facet |
Yan Li Carol A. Pollock Sonia Saad |
author_sort |
Yan Li |
title |
Aberrant DNA Methylation Mediates the Transgenerational Risk of Metabolic and Chronic Disease Due to Maternal Obesity and Overnutrition |
title_short |
Aberrant DNA Methylation Mediates the Transgenerational Risk of Metabolic and Chronic Disease Due to Maternal Obesity and Overnutrition |
title_full |
Aberrant DNA Methylation Mediates the Transgenerational Risk of Metabolic and Chronic Disease Due to Maternal Obesity and Overnutrition |
title_fullStr |
Aberrant DNA Methylation Mediates the Transgenerational Risk of Metabolic and Chronic Disease Due to Maternal Obesity and Overnutrition |
title_full_unstemmed |
Aberrant DNA Methylation Mediates the Transgenerational Risk of Metabolic and Chronic Disease Due to Maternal Obesity and Overnutrition |
title_sort |
aberrant dna methylation mediates the transgenerational risk of metabolic and chronic disease due to maternal obesity and overnutrition |
publisher |
MDPI AG |
publishDate |
2021 |
url |
https://doaj.org/article/253c9a1e870c4951879a05bd406c7537 |
work_keys_str_mv |
AT yanli aberrantdnamethylationmediatesthetransgenerationalriskofmetabolicandchronicdiseaseduetomaternalobesityandovernutrition AT carolapollock aberrantdnamethylationmediatesthetransgenerationalriskofmetabolicandchronicdiseaseduetomaternalobesityandovernutrition AT soniasaad aberrantdnamethylationmediatesthetransgenerationalriskofmetabolicandchronicdiseaseduetomaternalobesityandovernutrition |
_version_ |
1718412092896182272 |