Self-assembling human heart organoids for the modeling of cardiac development and congenital heart disease

There is a pressing need to develop representative organ-like platforms recapitulating complex in vivo phenotypes to study human development and disease in vitro. Here the authors present a method to generate human heart organoids by self-assembly using pluripotent stem cells, compare these to age-m...

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Autores principales:	Yonatan R. Lewis-Israeli, Aaron H. Wasserman, Mitchell A. Gabalski, Brett D. Volmert, Yixuan Ming, Kristen A. Ball, Weiyang Yang, Jinyun Zou, Guangming Ni, Natalia Pajares, Xanthippi Chatzistavrou, Wen Li, Chao Zhou, Aitor Aguirre
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/253ca09085994e7ca7cf500eaaf085e0
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spelling	oai:doaj.org-article:253ca09085994e7ca7cf500eaaf085e02021-12-02T16:35:13ZSelf-assembling human heart organoids for the modeling of cardiac development and congenital heart disease10.1038/s41467-021-25329-52041-1723https://doaj.org/article/253ca09085994e7ca7cf500eaaf085e02021-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25329-5https://doaj.org/toc/2041-1723There is a pressing need to develop representative organ-like platforms recapitulating complex in vivo phenotypes to study human development and disease in vitro. Here the authors present a method to generate human heart organoids by self-assembly using pluripotent stem cells, compare these to age-matched fetal cardiac tissues and recreate a model of pregestational diabetes.Yonatan R. Lewis-IsraeliAaron H. WassermanMitchell A. GabalskiBrett D. VolmertYixuan MingKristen A. BallWeiyang YangJinyun ZouGuangming NiNatalia PajaresXanthippi ChatzistavrouWen LiChao ZhouAitor AguirreNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yonatan R. Lewis-Israeli Aaron H. Wasserman Mitchell A. Gabalski Brett D. Volmert Yixuan Ming Kristen A. Ball Weiyang Yang Jinyun Zou Guangming Ni Natalia Pajares Xanthippi Chatzistavrou Wen Li Chao Zhou Aitor Aguirre Self-assembling human heart organoids for the modeling of cardiac development and congenital heart disease
description	There is a pressing need to develop representative organ-like platforms recapitulating complex in vivo phenotypes to study human development and disease in vitro. Here the authors present a method to generate human heart organoids by self-assembly using pluripotent stem cells, compare these to age-matched fetal cardiac tissues and recreate a model of pregestational diabetes.
format	article
author	Yonatan R. Lewis-Israeli Aaron H. Wasserman Mitchell A. Gabalski Brett D. Volmert Yixuan Ming Kristen A. Ball Weiyang Yang Jinyun Zou Guangming Ni Natalia Pajares Xanthippi Chatzistavrou Wen Li Chao Zhou Aitor Aguirre
author_facet	Yonatan R. Lewis-Israeli Aaron H. Wasserman Mitchell A. Gabalski Brett D. Volmert Yixuan Ming Kristen A. Ball Weiyang Yang Jinyun Zou Guangming Ni Natalia Pajares Xanthippi Chatzistavrou Wen Li Chao Zhou Aitor Aguirre
author_sort	Yonatan R. Lewis-Israeli
title	Self-assembling human heart organoids for the modeling of cardiac development and congenital heart disease
title_short	Self-assembling human heart organoids for the modeling of cardiac development and congenital heart disease
title_full	Self-assembling human heart organoids for the modeling of cardiac development and congenital heart disease
title_fullStr	Self-assembling human heart organoids for the modeling of cardiac development and congenital heart disease
title_full_unstemmed	Self-assembling human heart organoids for the modeling of cardiac development and congenital heart disease
title_sort	self-assembling human heart organoids for the modeling of cardiac development and congenital heart disease
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/253ca09085994e7ca7cf500eaaf085e0
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Self-assembling human heart organoids for the modeling of cardiac development and congenital heart disease

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