Chronic features of allergic asthma are enhanced in the absence of resistin-like molecule-beta

Abstract Asthma is characterized by inflammation and architectural changes in the lungs. A number of immune cells and mediators are recognized as initiators of asthma, although therapeutics based on these are not always effective. The multifaceted nature of this syndrome necessitate continued explor...

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Autores principales:	Kim S. LeMessurier, Maneesha Palipane, Meenakshi Tiwary, Brian Gavin, Amali E. Samarasinghe
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/2540486920914b8d8a0b4addaafee7d5
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spelling	oai:doaj.org-article:2540486920914b8d8a0b4addaafee7d52021-12-02T16:08:15ZChronic features of allergic asthma are enhanced in the absence of resistin-like molecule-beta10.1038/s41598-018-25321-y2045-2322https://doaj.org/article/2540486920914b8d8a0b4addaafee7d52018-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-25321-yhttps://doaj.org/toc/2045-2322Abstract Asthma is characterized by inflammation and architectural changes in the lungs. A number of immune cells and mediators are recognized as initiators of asthma, although therapeutics based on these are not always effective. The multifaceted nature of this syndrome necessitate continued exploration of immunomodulators that may play a role in pathogenesis. We investigated the role of resistin-like molecule-beta (RELM-β), a gut antibacterial, in the development and pathogenesis of Aspergillus-induced allergic airways disease. Age and gender matched C57BL/6J and Retnlb −/− mice rendered allergic to Aspergillus fumigatus were used to measure canonical markers of allergic asthma at early and late time points. Inflammatory cells in airways were similar, although Retnlb −/− mice had reduced tissue inflammation. The absence of RELM-β elevated serum IgA and pro-inflammatory cytokines in the lungs at homeostasis. Markers of chronic disease including goblet cell numbers, Muc genes, airway wall remodelling, and hyperresponsiveness were greater in the absence RELM-β. Specific inflammatory mediators important in antimicrobial defence in allergic asthma were also increased in the absence of RELM-β. These data suggest that while characteristics of allergic asthma develop in the absence of RELM-β, that RELM-β may reduce the development of chronic markers of allergic airways disease.Kim S. LeMessurierManeesha PalipaneMeenakshi TiwaryBrian GavinAmali E. SamarasingheNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-13 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Kim S. LeMessurier Maneesha Palipane Meenakshi Tiwary Brian Gavin Amali E. Samarasinghe Chronic features of allergic asthma are enhanced in the absence of resistin-like molecule-beta
description	Abstract Asthma is characterized by inflammation and architectural changes in the lungs. A number of immune cells and mediators are recognized as initiators of asthma, although therapeutics based on these are not always effective. The multifaceted nature of this syndrome necessitate continued exploration of immunomodulators that may play a role in pathogenesis. We investigated the role of resistin-like molecule-beta (RELM-β), a gut antibacterial, in the development and pathogenesis of Aspergillus-induced allergic airways disease. Age and gender matched C57BL/6J and Retnlb −/− mice rendered allergic to Aspergillus fumigatus were used to measure canonical markers of allergic asthma at early and late time points. Inflammatory cells in airways were similar, although Retnlb −/− mice had reduced tissue inflammation. The absence of RELM-β elevated serum IgA and pro-inflammatory cytokines in the lungs at homeostasis. Markers of chronic disease including goblet cell numbers, Muc genes, airway wall remodelling, and hyperresponsiveness were greater in the absence RELM-β. Specific inflammatory mediators important in antimicrobial defence in allergic asthma were also increased in the absence of RELM-β. These data suggest that while characteristics of allergic asthma develop in the absence of RELM-β, that RELM-β may reduce the development of chronic markers of allergic airways disease.
format	article
author	Kim S. LeMessurier Maneesha Palipane Meenakshi Tiwary Brian Gavin Amali E. Samarasinghe
author_facet	Kim S. LeMessurier Maneesha Palipane Meenakshi Tiwary Brian Gavin Amali E. Samarasinghe
author_sort	Kim S. LeMessurier
title	Chronic features of allergic asthma are enhanced in the absence of resistin-like molecule-beta
title_short	Chronic features of allergic asthma are enhanced in the absence of resistin-like molecule-beta
title_full	Chronic features of allergic asthma are enhanced in the absence of resistin-like molecule-beta
title_fullStr	Chronic features of allergic asthma are enhanced in the absence of resistin-like molecule-beta
title_full_unstemmed	Chronic features of allergic asthma are enhanced in the absence of resistin-like molecule-beta
title_sort	chronic features of allergic asthma are enhanced in the absence of resistin-like molecule-beta
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/2540486920914b8d8a0b4addaafee7d5
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Chronic features of allergic asthma are enhanced in the absence of resistin-like molecule-beta

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