Insights into the assembly and architecture of a Staufen-mediated mRNA decay (SMD)-competent mRNP

The Staufen proteins recognize secondary structures in 3’-untranslated regions in mRNA transcripts and induce degradation of these mRNAs with the help of the RNA helicase UPF1. Here the authors report that the nonsense-mediated mRNA decay factor UPF2 mediates the interaction between Stau1 and UPF1 i...

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Autores principales:	Manjeera Gowravaram, Juliane Schwarz, Sana K. Khilji, Henning Urlaub, Sutapa Chakrabarti
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/254321cfddc94877a3603f84eb782f0d
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spelling	oai:doaj.org-article:254321cfddc94877a3603f84eb782f0d2021-12-02T14:39:57ZInsights into the assembly and architecture of a Staufen-mediated mRNA decay (SMD)-competent mRNP10.1038/s41467-019-13080-x2041-1723https://doaj.org/article/254321cfddc94877a3603f84eb782f0d2019-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13080-xhttps://doaj.org/toc/2041-1723The Staufen proteins recognize secondary structures in 3’-untranslated regions in mRNA transcripts and induce degradation of these mRNAs with the help of the RNA helicase UPF1. Here the authors report that the nonsense-mediated mRNA decay factor UPF2 mediates the interaction between Stau1 and UPF1 in Staufen-mediated mRNA decay.Manjeera GowravaramJuliane SchwarzSana K. KhiljiHenning UrlaubSutapa ChakrabartiNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Manjeera Gowravaram Juliane Schwarz Sana K. Khilji Henning Urlaub Sutapa Chakrabarti Insights into the assembly and architecture of a Staufen-mediated mRNA decay (SMD)-competent mRNP
description	The Staufen proteins recognize secondary structures in 3’-untranslated regions in mRNA transcripts and induce degradation of these mRNAs with the help of the RNA helicase UPF1. Here the authors report that the nonsense-mediated mRNA decay factor UPF2 mediates the interaction between Stau1 and UPF1 in Staufen-mediated mRNA decay.
format	article
author	Manjeera Gowravaram Juliane Schwarz Sana K. Khilji Henning Urlaub Sutapa Chakrabarti
author_facet	Manjeera Gowravaram Juliane Schwarz Sana K. Khilji Henning Urlaub Sutapa Chakrabarti
author_sort	Manjeera Gowravaram
title	Insights into the assembly and architecture of a Staufen-mediated mRNA decay (SMD)-competent mRNP
title_short	Insights into the assembly and architecture of a Staufen-mediated mRNA decay (SMD)-competent mRNP
title_full	Insights into the assembly and architecture of a Staufen-mediated mRNA decay (SMD)-competent mRNP
title_fullStr	Insights into the assembly and architecture of a Staufen-mediated mRNA decay (SMD)-competent mRNP
title_full_unstemmed	Insights into the assembly and architecture of a Staufen-mediated mRNA decay (SMD)-competent mRNP
title_sort	insights into the assembly and architecture of a staufen-mediated mrna decay (smd)-competent mrnp
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/254321cfddc94877a3603f84eb782f0d
work_keys_str_mv	AT manjeeragowravaram insightsintotheassemblyandarchitectureofastaufenmediatedmrnadecaysmdcompetentmrnp AT julianeschwarz insightsintotheassemblyandarchitectureofastaufenmediatedmrnadecaysmdcompetentmrnp AT sanakkhilji insightsintotheassemblyandarchitectureofastaufenmediatedmrnadecaysmdcompetentmrnp AT henningurlaub insightsintotheassemblyandarchitectureofastaufenmediatedmrnadecaysmdcompetentmrnp AT sutapachakrabarti insightsintotheassemblyandarchitectureofastaufenmediatedmrnadecaysmdcompetentmrnp
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Insights into the assembly and architecture of a Staufen-mediated mRNA decay (SMD)-competent mRNP

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