Insights into the assembly and architecture of a Staufen-mediated mRNA decay (SMD)-competent mRNP

Insights into the assembly and architecture of a Staufen-mediated mRNA decay (SMD)-competent mRNP

The Staufen proteins recognize secondary structures in 3’-untranslated regions in mRNA transcripts and induce degradation of these mRNAs with the help of the RNA helicase UPF1. Here the authors report that the nonsense-mediated mRNA decay factor UPF2 mediates the interaction between Stau1 and UPF1 i...

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Autores principales: Manjeera Gowravaram, Juliane Schwarz, Sana K. Khilji, Henning Urlaub, Sutapa Chakrabarti
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Science
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Acceso en línea:https://doaj.org/article/254321cfddc94877a3603f84eb782f0d
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