Outcomes of elderly patients with organophosphate intoxication

Abstract This study analysed the clinical patterns and outcomes of elderly patients with organophosphate intoxication. A total of 71 elderly patients with organophosphate poisoning were seen between 2008 and 2017. Patients were stratified into two subgroups: survivors (n = 57) or nonsurvivors (n = 1...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Jia-Ruei Yu, Yi-Chou Hou, Jen-Fen Fu, I-Kuan Wang, Ming‐Jen Chan, Chao-Yu Chen, Cheng-Hao Weng, Wen-Hung Huang, Huang-Yu Yang, Ching-Wei Hsu, Tzung-Hai Yen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/25436325ce6b460d92ff3c2e05c82b20
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:25436325ce6b460d92ff3c2e05c82b20
record_format	dspace
spelling	oai:doaj.org-article:25436325ce6b460d92ff3c2e05c82b202021-12-02T18:24:54ZOutcomes of elderly patients with organophosphate intoxication10.1038/s41598-021-91230-22045-2322https://doaj.org/article/25436325ce6b460d92ff3c2e05c82b202021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-91230-2https://doaj.org/toc/2045-2322Abstract This study analysed the clinical patterns and outcomes of elderly patients with organophosphate intoxication. A total of 71 elderly patients with organophosphate poisoning were seen between 2008 and 2017. Patients were stratified into two subgroups: survivors (n = 57) or nonsurvivors (n = 14). Chlorpyrifos accounted for 33.8% of the cases, followed by methamidophos (12.7%) and mevinphos (11.3%). Mood, adjustment and psychotic disorder were noted in 39.4%, 33.8% and 2.8% of patients, respectively. All patients were treated with atropine and pralidoxime therapies. Acute cholinergic crisis developed in all cases (100.0%). The complications included respiratory failure (52.1%), aspiration pneumonia (50.7%), acute kidney injury (43.7%), severe consciousness disturbance (25.4%), shock (14.1%) and seizures (4.2%). Some patients also developed intermediate syndrome (15.5%) and delayed neuropathy (4.2%). The nonsurvivors suffered higher rates of hypotension (P < 0.001), shock (P < 0.001) and kidney injury (P = 0.001) than survivors did. Kaplan–Meier analysis indicated that patients with shock suffered lower cumulative survival than did patients without shock (log-rank test, P < 0.001). In a multivariate-Cox-regression model, shock was a significant predictor of mortality after intoxication (odds ratio 18.182, 95% confidence interval 2.045–166.667, P = 0.009). The mortality rate was 19.7%. Acute cholinergic crisis, intermediate syndrome, and delayed neuropathy developed in 100.0%, 15.5%, and 4.2% of patients, respectively.Jia-Ruei YuYi-Chou HouJen-Fen FuI-Kuan WangMing‐Jen ChanChao-Yu ChenCheng-Hao WengWen-Hung HuangHuang-Yu YangChing-Wei HsuTzung-Hai YenNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jia-Ruei Yu Yi-Chou Hou Jen-Fen Fu I-Kuan Wang Ming‐Jen Chan Chao-Yu Chen Cheng-Hao Weng Wen-Hung Huang Huang-Yu Yang Ching-Wei Hsu Tzung-Hai Yen Outcomes of elderly patients with organophosphate intoxication
description	Abstract This study analysed the clinical patterns and outcomes of elderly patients with organophosphate intoxication. A total of 71 elderly patients with organophosphate poisoning were seen between 2008 and 2017. Patients were stratified into two subgroups: survivors (n = 57) or nonsurvivors (n = 14). Chlorpyrifos accounted for 33.8% of the cases, followed by methamidophos (12.7%) and mevinphos (11.3%). Mood, adjustment and psychotic disorder were noted in 39.4%, 33.8% and 2.8% of patients, respectively. All patients were treated with atropine and pralidoxime therapies. Acute cholinergic crisis developed in all cases (100.0%). The complications included respiratory failure (52.1%), aspiration pneumonia (50.7%), acute kidney injury (43.7%), severe consciousness disturbance (25.4%), shock (14.1%) and seizures (4.2%). Some patients also developed intermediate syndrome (15.5%) and delayed neuropathy (4.2%). The nonsurvivors suffered higher rates of hypotension (P < 0.001), shock (P < 0.001) and kidney injury (P = 0.001) than survivors did. Kaplan–Meier analysis indicated that patients with shock suffered lower cumulative survival than did patients without shock (log-rank test, P < 0.001). In a multivariate-Cox-regression model, shock was a significant predictor of mortality after intoxication (odds ratio 18.182, 95% confidence interval 2.045–166.667, P = 0.009). The mortality rate was 19.7%. Acute cholinergic crisis, intermediate syndrome, and delayed neuropathy developed in 100.0%, 15.5%, and 4.2% of patients, respectively.
format	article
author	Jia-Ruei Yu Yi-Chou Hou Jen-Fen Fu I-Kuan Wang Ming‐Jen Chan Chao-Yu Chen Cheng-Hao Weng Wen-Hung Huang Huang-Yu Yang Ching-Wei Hsu Tzung-Hai Yen
author_facet	Jia-Ruei Yu Yi-Chou Hou Jen-Fen Fu I-Kuan Wang Ming‐Jen Chan Chao-Yu Chen Cheng-Hao Weng Wen-Hung Huang Huang-Yu Yang Ching-Wei Hsu Tzung-Hai Yen
author_sort	Jia-Ruei Yu
title	Outcomes of elderly patients with organophosphate intoxication
title_short	Outcomes of elderly patients with organophosphate intoxication
title_full	Outcomes of elderly patients with organophosphate intoxication
title_fullStr	Outcomes of elderly patients with organophosphate intoxication
title_full_unstemmed	Outcomes of elderly patients with organophosphate intoxication
title_sort	outcomes of elderly patients with organophosphate intoxication
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/25436325ce6b460d92ff3c2e05c82b20
work_keys_str_mv	AT jiarueiyu outcomesofelderlypatientswithorganophosphateintoxication AT yichouhou outcomesofelderlypatientswithorganophosphateintoxication AT jenfenfu outcomesofelderlypatientswithorganophosphateintoxication AT ikuanwang outcomesofelderlypatientswithorganophosphateintoxication AT mingjenchan outcomesofelderlypatientswithorganophosphateintoxication AT chaoyuchen outcomesofelderlypatientswithorganophosphateintoxication AT chenghaoweng outcomesofelderlypatientswithorganophosphateintoxication AT wenhunghuang outcomesofelderlypatientswithorganophosphateintoxication AT huangyuyang outcomesofelderlypatientswithorganophosphateintoxication AT chingweihsu outcomesofelderlypatientswithorganophosphateintoxication AT tzunghaiyen outcomesofelderlypatientswithorganophosphateintoxication
_version_	1718378082870493184

Outcomes of elderly patients with organophosphate intoxication

Ejemplares similares