Identification of the fungal ligand triggering cytotoxic PRR-mediated NK cell killing of Cryptococcus and Candida

Natural killer (NK) cells has been show to mediate fungi killing via the activating receptor NKp30, but the fungal target for NKp30 is still unclear. Here the authors show, using atomic force microscopy and live cell imaging, that β-1,3-glucan is expressed by Cryptococcus neoformans and Candida albi...

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Autores principales:	Shu Shun Li, Henry Ogbomo, Michael K. Mansour, Richard F. Xiang, Lian Szabo, Fay Munro, Priyanka Mukherjee, Roy A. Mariuzza, Matthias Amrein, Jatin M. Vyas, Stephen M. Robbins, Christopher H. Mody
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/2544882c0af34f56b6d9c66dfded2082
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spelling	oai:doaj.org-article:2544882c0af34f56b6d9c66dfded20822021-12-02T15:33:36ZIdentification of the fungal ligand triggering cytotoxic PRR-mediated NK cell killing of Cryptococcus and Candida10.1038/s41467-018-03014-42041-1723https://doaj.org/article/2544882c0af34f56b6d9c66dfded20822018-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03014-4https://doaj.org/toc/2041-1723Natural killer (NK) cells has been show to mediate fungi killing via the activating receptor NKp30, but the fungal target for NKp30 is still unclear. Here the authors show, using atomic force microscopy and live cell imaging, that β-1,3-glucan is expressed by Cryptococcus neoformans and Candida albicans and responsible for NKp30-mediated NK killing.Shu Shun LiHenry OgbomoMichael K. MansourRichard F. XiangLian SzaboFay MunroPriyanka MukherjeeRoy A. MariuzzaMatthias AmreinJatin M. VyasStephen M. RobbinsChristopher H. ModyNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Shu Shun Li Henry Ogbomo Michael K. Mansour Richard F. Xiang Lian Szabo Fay Munro Priyanka Mukherjee Roy A. Mariuzza Matthias Amrein Jatin M. Vyas Stephen M. Robbins Christopher H. Mody Identification of the fungal ligand triggering cytotoxic PRR-mediated NK cell killing of Cryptococcus and Candida
description	Natural killer (NK) cells has been show to mediate fungi killing via the activating receptor NKp30, but the fungal target for NKp30 is still unclear. Here the authors show, using atomic force microscopy and live cell imaging, that β-1,3-glucan is expressed by Cryptococcus neoformans and Candida albicans and responsible for NKp30-mediated NK killing.
format	article
author	Shu Shun Li Henry Ogbomo Michael K. Mansour Richard F. Xiang Lian Szabo Fay Munro Priyanka Mukherjee Roy A. Mariuzza Matthias Amrein Jatin M. Vyas Stephen M. Robbins Christopher H. Mody
author_facet	Shu Shun Li Henry Ogbomo Michael K. Mansour Richard F. Xiang Lian Szabo Fay Munro Priyanka Mukherjee Roy A. Mariuzza Matthias Amrein Jatin M. Vyas Stephen M. Robbins Christopher H. Mody
author_sort	Shu Shun Li
title	Identification of the fungal ligand triggering cytotoxic PRR-mediated NK cell killing of Cryptococcus and Candida
title_short	Identification of the fungal ligand triggering cytotoxic PRR-mediated NK cell killing of Cryptococcus and Candida
title_full	Identification of the fungal ligand triggering cytotoxic PRR-mediated NK cell killing of Cryptococcus and Candida
title_fullStr	Identification of the fungal ligand triggering cytotoxic PRR-mediated NK cell killing of Cryptococcus and Candida
title_full_unstemmed	Identification of the fungal ligand triggering cytotoxic PRR-mediated NK cell killing of Cryptococcus and Candida
title_sort	identification of the fungal ligand triggering cytotoxic prr-mediated nk cell killing of cryptococcus and candida
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/2544882c0af34f56b6d9c66dfded2082
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Identification of the fungal ligand triggering cytotoxic PRR-mediated NK cell killing of Cryptococcus and Candida

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