Inhibition of lung tumorigenesis by a small molecule CA170 targeting the immune checkpoint protein VISTA

Pan, Chen, Zhang et al. investigated the anti-cancer efficacy of CA170, a small molecule agonist of VISTA, on mouse lung tumorigenesis. When combined with a MHCII-directed KRAS peptide vaccine, the authors reported that CA170 suppressed lung tumor development by increasing CD8+ T cell and decreasing...

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Autores principales:	Jing Pan, Yao Chen, Qi Zhang, Achia Khatun, Katie Palen, Gang Xin, Li Wang, Chuanjia Yang, Bryon D. Johnson, Charles R. Myers, Shizuko Sei, Robert H. Shoemaker, Ronald A. Lubet, Yian Wang, Weiguo Cui, Ming You
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/25463f045f454089abc25f6e7b64cc74
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spelling	oai:doaj.org-article:25463f045f454089abc25f6e7b64cc742021-12-02T16:17:27ZInhibition of lung tumorigenesis by a small molecule CA170 targeting the immune checkpoint protein VISTA10.1038/s42003-021-02381-x2399-3642https://doaj.org/article/25463f045f454089abc25f6e7b64cc742021-07-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-02381-xhttps://doaj.org/toc/2399-3642Pan, Chen, Zhang et al. investigated the anti-cancer efficacy of CA170, a small molecule agonist of VISTA, on mouse lung tumorigenesis. When combined with a MHCII-directed KRAS peptide vaccine, the authors reported that CA170 suppressed lung tumor development by increasing CD8+ T cell and decreasing MDSC and Treg infiltration, while the Kras vaccine induced CD4+ effector T cell expansionJing PanYao ChenQi ZhangAchia KhatunKatie PalenGang XinLi WangChuanjia YangBryon D. JohnsonCharles R. MyersShizuko SeiRobert H. ShoemakerRonald A. LubetYian WangWeiguo CuiMing YouNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Jing Pan Yao Chen Qi Zhang Achia Khatun Katie Palen Gang Xin Li Wang Chuanjia Yang Bryon D. Johnson Charles R. Myers Shizuko Sei Robert H. Shoemaker Ronald A. Lubet Yian Wang Weiguo Cui Ming You Inhibition of lung tumorigenesis by a small molecule CA170 targeting the immune checkpoint protein VISTA
description	Pan, Chen, Zhang et al. investigated the anti-cancer efficacy of CA170, a small molecule agonist of VISTA, on mouse lung tumorigenesis. When combined with a MHCII-directed KRAS peptide vaccine, the authors reported that CA170 suppressed lung tumor development by increasing CD8+ T cell and decreasing MDSC and Treg infiltration, while the Kras vaccine induced CD4+ effector T cell expansion
format	article
author	Jing Pan Yao Chen Qi Zhang Achia Khatun Katie Palen Gang Xin Li Wang Chuanjia Yang Bryon D. Johnson Charles R. Myers Shizuko Sei Robert H. Shoemaker Ronald A. Lubet Yian Wang Weiguo Cui Ming You
author_facet	Jing Pan Yao Chen Qi Zhang Achia Khatun Katie Palen Gang Xin Li Wang Chuanjia Yang Bryon D. Johnson Charles R. Myers Shizuko Sei Robert H. Shoemaker Ronald A. Lubet Yian Wang Weiguo Cui Ming You
author_sort	Jing Pan
title	Inhibition of lung tumorigenesis by a small molecule CA170 targeting the immune checkpoint protein VISTA
title_short	Inhibition of lung tumorigenesis by a small molecule CA170 targeting the immune checkpoint protein VISTA
title_full	Inhibition of lung tumorigenesis by a small molecule CA170 targeting the immune checkpoint protein VISTA
title_fullStr	Inhibition of lung tumorigenesis by a small molecule CA170 targeting the immune checkpoint protein VISTA
title_full_unstemmed	Inhibition of lung tumorigenesis by a small molecule CA170 targeting the immune checkpoint protein VISTA
title_sort	inhibition of lung tumorigenesis by a small molecule ca170 targeting the immune checkpoint protein vista
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/25463f045f454089abc25f6e7b64cc74
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Inhibition of lung tumorigenesis by a small molecule CA170 targeting the immune checkpoint protein VISTA

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