Brown adipose tissue ameliorates autoimmune arthritis via inhibition of Th17 cells

Abstract The functions of adipose tissue are associated with autoimmune diseases, such as rheumatoid arthritis (RA). Some studies have shown that the three compositions of adipose tissue (white, brown, and beige) have different functions. Brown adipose tissue (BAT) is known to secrete several factor...

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Autores principales:	Jeonghyeon Moon, Dasom Kim, Eun Kyung Kim, Seon-yeong Lee, Hyun Sik Na, Gyoung Nyun Kim, Aram Lee, KyungAh Jung, Jeong Won Choi, Sung-Hwan Park, Sangho Roh, Mi-La Cho
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/2546c132fe9a4c2bbdea1720a05afa63
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spelling	oai:doaj.org-article:2546c132fe9a4c2bbdea1720a05afa632021-12-02T16:26:21ZBrown adipose tissue ameliorates autoimmune arthritis via inhibition of Th17 cells10.1038/s41598-020-68749-x2045-2322https://doaj.org/article/2546c132fe9a4c2bbdea1720a05afa632020-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-68749-xhttps://doaj.org/toc/2045-2322Abstract The functions of adipose tissue are associated with autoimmune diseases, such as rheumatoid arthritis (RA). Some studies have shown that the three compositions of adipose tissue (white, brown, and beige) have different functions. Brown adipose tissue (BAT) is known to secrete several factors that differ from those in white adipose tissue. This suggests that BAT might have potential positive advantages in the physiology of autoimmune diseases. We compared the functions of collagen-induced arthritis mice-derived BAT (CIA BAT) with normal mice-derived BAT. DBA/1J mice (6–7 weeks of age) were immunized by intradermal injection at the base of the tail with 100 μg of bovine type II collagen (CII) emulsified in complete Freund’s adjuvant. Immunized mice then received booster immunizations by intraperitoneal injection with 100 μg of CII in incomplete Freund’s adjuvant. We transplanted CIA BAT and normal BAT into CIA recipient mice. After transplantation, we measured the functions of CIA BAT and normal BAT in mice. Normal BAT-transplanted mice showed significantly lower scores of bone damage, inflammation, and cartilage damage. The proinflammatory cytokines in normal BAT-transplanted mice, such as IL-12, IL-17, IL-6, and tumor necrosis factor-α (TNF-α), tended to decrease. Microarray analysis showed that the PI3K-AKT signaling pathway and IL-17 levels of CIA BAT tissues were significantly higher than those of normal BAT tissues. These results suggest that the transplantation of normal brown fat may have a therapeutic effect in RA patients.Jeonghyeon MoonDasom KimEun Kyung KimSeon-yeong LeeHyun Sik NaGyoung Nyun KimAram LeeKyungAh JungJeong Won ChoiSung-Hwan ParkSangho RohMi-La ChoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-11 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jeonghyeon Moon Dasom Kim Eun Kyung Kim Seon-yeong Lee Hyun Sik Na Gyoung Nyun Kim Aram Lee KyungAh Jung Jeong Won Choi Sung-Hwan Park Sangho Roh Mi-La Cho Brown adipose tissue ameliorates autoimmune arthritis via inhibition of Th17 cells
description	Abstract The functions of adipose tissue are associated with autoimmune diseases, such as rheumatoid arthritis (RA). Some studies have shown that the three compositions of adipose tissue (white, brown, and beige) have different functions. Brown adipose tissue (BAT) is known to secrete several factors that differ from those in white adipose tissue. This suggests that BAT might have potential positive advantages in the physiology of autoimmune diseases. We compared the functions of collagen-induced arthritis mice-derived BAT (CIA BAT) with normal mice-derived BAT. DBA/1J mice (6–7 weeks of age) were immunized by intradermal injection at the base of the tail with 100 μg of bovine type II collagen (CII) emulsified in complete Freund’s adjuvant. Immunized mice then received booster immunizations by intraperitoneal injection with 100 μg of CII in incomplete Freund’s adjuvant. We transplanted CIA BAT and normal BAT into CIA recipient mice. After transplantation, we measured the functions of CIA BAT and normal BAT in mice. Normal BAT-transplanted mice showed significantly lower scores of bone damage, inflammation, and cartilage damage. The proinflammatory cytokines in normal BAT-transplanted mice, such as IL-12, IL-17, IL-6, and tumor necrosis factor-α (TNF-α), tended to decrease. Microarray analysis showed that the PI3K-AKT signaling pathway and IL-17 levels of CIA BAT tissues were significantly higher than those of normal BAT tissues. These results suggest that the transplantation of normal brown fat may have a therapeutic effect in RA patients.
format	article
author	Jeonghyeon Moon Dasom Kim Eun Kyung Kim Seon-yeong Lee Hyun Sik Na Gyoung Nyun Kim Aram Lee KyungAh Jung Jeong Won Choi Sung-Hwan Park Sangho Roh Mi-La Cho
author_facet	Jeonghyeon Moon Dasom Kim Eun Kyung Kim Seon-yeong Lee Hyun Sik Na Gyoung Nyun Kim Aram Lee KyungAh Jung Jeong Won Choi Sung-Hwan Park Sangho Roh Mi-La Cho
author_sort	Jeonghyeon Moon
title	Brown adipose tissue ameliorates autoimmune arthritis via inhibition of Th17 cells
title_short	Brown adipose tissue ameliorates autoimmune arthritis via inhibition of Th17 cells
title_full	Brown adipose tissue ameliorates autoimmune arthritis via inhibition of Th17 cells
title_fullStr	Brown adipose tissue ameliorates autoimmune arthritis via inhibition of Th17 cells
title_full_unstemmed	Brown adipose tissue ameliorates autoimmune arthritis via inhibition of Th17 cells
title_sort	brown adipose tissue ameliorates autoimmune arthritis via inhibition of th17 cells
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/2546c132fe9a4c2bbdea1720a05afa63
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Brown adipose tissue ameliorates autoimmune arthritis via inhibition of Th17 cells

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