Effect of depressive symptom and depressive disorder on glaucoma incidence in elderly

Abstract Although depression and glaucoma share several common pathophysiology, the risk of glaucoma in patients with depression has not been reported. Thus, we investigated the effect of depressive symptom and depressive disorder on glaucoma incidence. In this nationwide population-based cohort stu...

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Autores principales:	Younhea Jung, Kyungdo Han, Sheng-min Wang, Hye yeon Yoon, Jung Il Moon
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/254c36c061d146d8a2e84555a144ea99
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spelling	oai:doaj.org-article:254c36c061d146d8a2e84555a144ea992021-12-02T13:17:42ZEffect of depressive symptom and depressive disorder on glaucoma incidence in elderly10.1038/s41598-021-85380-62045-2322https://doaj.org/article/254c36c061d146d8a2e84555a144ea992021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-85380-6https://doaj.org/toc/2045-2322Abstract Although depression and glaucoma share several common pathophysiology, the risk of glaucoma in patients with depression has not been reported. Thus, we investigated the effect of depressive symptom and depressive disorder on glaucoma incidence. In this nationwide population-based cohort study, all subjects receiving the National Screening Program at the age of 66 during 2009–2014 were included. These subjects were divided into depression group and no depression group based on subjective depressive symptoms and clinically diagnosed depressive disorder and were tracked until 2017 for development of glaucoma. Of the 922,769 subjects included in the study, 191,636 (20.77%) subjects were categorized as depression group. Subjects with depression showed increased hazard of developing glaucoma (adjusted HR = 1.12[95% confidence interval (CI), 1.09–1.15]) than those without depression. The risk of glaucoma increased sequentially from those with no depression to those with subjective depressive symptom (adjusted HR = 1.09[95% CI, 1.06–1.13]), those with clinically diagnosed depressive disorder (adjusted HR = 1.23[95% CI, 1.14–1.32]), and those with both subjective depressive symptom and clinically diagnosed depressive disorder (adjusted HR = 1.36[95% CI, 1.22–1.52]). Our analyses suggest that individuals with depression had a greater risk of developing glaucoma than those without depression. Subjective depressive symptoms and clinically diagnosed depressive disorder independently and synergistically increased the risk of glaucoma incidence.Younhea JungKyungdo HanSheng-min WangHye yeon YoonJung Il MoonNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Younhea Jung Kyungdo Han Sheng-min Wang Hye yeon Yoon Jung Il Moon Effect of depressive symptom and depressive disorder on glaucoma incidence in elderly
description	Abstract Although depression and glaucoma share several common pathophysiology, the risk of glaucoma in patients with depression has not been reported. Thus, we investigated the effect of depressive symptom and depressive disorder on glaucoma incidence. In this nationwide population-based cohort study, all subjects receiving the National Screening Program at the age of 66 during 2009–2014 were included. These subjects were divided into depression group and no depression group based on subjective depressive symptoms and clinically diagnosed depressive disorder and were tracked until 2017 for development of glaucoma. Of the 922,769 subjects included in the study, 191,636 (20.77%) subjects were categorized as depression group. Subjects with depression showed increased hazard of developing glaucoma (adjusted HR = 1.12[95% confidence interval (CI), 1.09–1.15]) than those without depression. The risk of glaucoma increased sequentially from those with no depression to those with subjective depressive symptom (adjusted HR = 1.09[95% CI, 1.06–1.13]), those with clinically diagnosed depressive disorder (adjusted HR = 1.23[95% CI, 1.14–1.32]), and those with both subjective depressive symptom and clinically diagnosed depressive disorder (adjusted HR = 1.36[95% CI, 1.22–1.52]). Our analyses suggest that individuals with depression had a greater risk of developing glaucoma than those without depression. Subjective depressive symptoms and clinically diagnosed depressive disorder independently and synergistically increased the risk of glaucoma incidence.
format	article
author	Younhea Jung Kyungdo Han Sheng-min Wang Hye yeon Yoon Jung Il Moon
author_facet	Younhea Jung Kyungdo Han Sheng-min Wang Hye yeon Yoon Jung Il Moon
author_sort	Younhea Jung
title	Effect of depressive symptom and depressive disorder on glaucoma incidence in elderly
title_short	Effect of depressive symptom and depressive disorder on glaucoma incidence in elderly
title_full	Effect of depressive symptom and depressive disorder on glaucoma incidence in elderly
title_fullStr	Effect of depressive symptom and depressive disorder on glaucoma incidence in elderly
title_full_unstemmed	Effect of depressive symptom and depressive disorder on glaucoma incidence in elderly
title_sort	effect of depressive symptom and depressive disorder on glaucoma incidence in elderly
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/254c36c061d146d8a2e84555a144ea99
work_keys_str_mv	AT younheajung effectofdepressivesymptomanddepressivedisorderonglaucomaincidenceinelderly AT kyungdohan effectofdepressivesymptomanddepressivedisorderonglaucomaincidenceinelderly AT shengminwang effectofdepressivesymptomanddepressivedisorderonglaucomaincidenceinelderly AT hyeyeonyoon effectofdepressivesymptomanddepressivedisorderonglaucomaincidenceinelderly AT jungilmoon effectofdepressivesymptomanddepressivedisorderonglaucomaincidenceinelderly
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Effect of depressive symptom and depressive disorder on glaucoma incidence in elderly

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