Cells recognize osmotic stress through liquid–liquid phase separation lubricated with poly(ADP-ribose)

Cells experience various osmotic perturbation, but cellular osmosensing mechanisms remain obscure. Here, the authors report that cells recognize osmotic stress from the inside through macromolecular crowding-driven and poly(ADP-ribose)-conditioned liquid–liquid phase separation.

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Autores principales:	Kengo Watanabe, Kazuhiro Morishita, Xiangyu Zhou, Shigeru Shiizaki, Yasuo Uchiyama, Masato Koike, Isao Naguro, Hidenori Ichijo
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/254e1803533c4a90b127c4e96c993a34
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spelling	oai:doaj.org-article:254e1803533c4a90b127c4e96c993a342021-12-02T15:52:56ZCells recognize osmotic stress through liquid–liquid phase separation lubricated with poly(ADP-ribose)10.1038/s41467-021-21614-52041-1723https://doaj.org/article/254e1803533c4a90b127c4e96c993a342021-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21614-5https://doaj.org/toc/2041-1723Cells experience various osmotic perturbation, but cellular osmosensing mechanisms remain obscure. Here, the authors report that cells recognize osmotic stress from the inside through macromolecular crowding-driven and poly(ADP-ribose)-conditioned liquid–liquid phase separation.Kengo WatanabeKazuhiro MorishitaXiangyu ZhouShigeru ShiizakiYasuo UchiyamaMasato KoikeIsao NaguroHidenori IchijoNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Kengo Watanabe Kazuhiro Morishita Xiangyu Zhou Shigeru Shiizaki Yasuo Uchiyama Masato Koike Isao Naguro Hidenori Ichijo Cells recognize osmotic stress through liquid–liquid phase separation lubricated with poly(ADP-ribose)
description	Cells experience various osmotic perturbation, but cellular osmosensing mechanisms remain obscure. Here, the authors report that cells recognize osmotic stress from the inside through macromolecular crowding-driven and poly(ADP-ribose)-conditioned liquid–liquid phase separation.
format	article
author	Kengo Watanabe Kazuhiro Morishita Xiangyu Zhou Shigeru Shiizaki Yasuo Uchiyama Masato Koike Isao Naguro Hidenori Ichijo
author_facet	Kengo Watanabe Kazuhiro Morishita Xiangyu Zhou Shigeru Shiizaki Yasuo Uchiyama Masato Koike Isao Naguro Hidenori Ichijo
author_sort	Kengo Watanabe
title	Cells recognize osmotic stress through liquid–liquid phase separation lubricated with poly(ADP-ribose)
title_short	Cells recognize osmotic stress through liquid–liquid phase separation lubricated with poly(ADP-ribose)
title_full	Cells recognize osmotic stress through liquid–liquid phase separation lubricated with poly(ADP-ribose)
title_fullStr	Cells recognize osmotic stress through liquid–liquid phase separation lubricated with poly(ADP-ribose)
title_full_unstemmed	Cells recognize osmotic stress through liquid–liquid phase separation lubricated with poly(ADP-ribose)
title_sort	cells recognize osmotic stress through liquid–liquid phase separation lubricated with poly(adp-ribose)
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/254e1803533c4a90b127c4e96c993a34
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Cells recognize osmotic stress through liquid–liquid phase separation lubricated with poly(ADP-ribose)

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