Cells recognize osmotic stress through liquid–liquid phase separation lubricated with poly(ADP-ribose)

Cells recognize osmotic stress through liquid–liquid phase separation lubricated with poly(ADP-ribose)

Cells experience various osmotic perturbation, but cellular osmosensing mechanisms remain obscure. Here, the authors report that cells recognize osmotic stress from the inside through macromolecular crowding-driven and poly(ADP-ribose)-conditioned liquid–liquid phase separation.

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Autores principales: Kengo Watanabe, Kazuhiro Morishita, Xiangyu Zhou, Shigeru Shiizaki, Yasuo Uchiyama, Masato Koike, Isao Naguro, Hidenori Ichijo
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Science
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Acceso en línea:https://doaj.org/article/254e1803533c4a90b127c4e96c993a34
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