Expression of L-type amino acid transporter 1 is a poor prognostic factor for Non-Hodgkin’s lymphoma

Abstract L-type neutral amino acid transporter 1 (LAT1) is a heterodimeric membrane transport protein involved in neutral amino acid transport. LAT1 is highly expressed in various malignant solid tumors and plays an essential role in cell proliferation. However, its role in malignant lymphoma remain...

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Autores principales:	Narangerel Jigjidkhorloo, Kohsuke Kanekura, Jun Matsubayashi, Daigo Akahane, Koji Fujita, Keiki Oikawa, Atsushi Kurata, Masakatsu Takanashi, Hitoshi Endou, Toshitaka Nagao, Akihiko Gotoh, Oyundelger Norov, Masahiko Kuroda
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/254f7aaec22f4688a7954b03fd1e965b
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spelling	oai:doaj.org-article:254f7aaec22f4688a7954b03fd1e965b2021-11-08T10:48:32ZExpression of L-type amino acid transporter 1 is a poor prognostic factor for Non-Hodgkin’s lymphoma10.1038/s41598-021-00811-82045-2322https://doaj.org/article/254f7aaec22f4688a7954b03fd1e965b2021-11-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-00811-8https://doaj.org/toc/2045-2322Abstract L-type neutral amino acid transporter 1 (LAT1) is a heterodimeric membrane transport protein involved in neutral amino acid transport. LAT1 is highly expressed in various malignant solid tumors and plays an essential role in cell proliferation. However, its role in malignant lymphoma remains unknown. Here, we evaluated LAT1 expression level in tissues from 138 patients with Non-Hodgkin lymphoma (NHL). Overexpression of LAT1 was confirmed in all types of NHL and we found that there is a significant correlation between the level of LAT1 expression and lymphoma grade. The LAT1 expression was higher in aggressive types of lymphomas when compared with static types of lymphomas, suggesting that active tumor proliferation requires nutrient uptake via LAT1. The expression level of LAT1 was inversely correlated with patients’ survival span. Furthermore, pharmacological inhibition of LAT1 by a specific inhibitor JPH203 inhibits lymphoma cell growth. In conclusion, our study demonstrated that LAT1 expression can be used as a prognostic marker for patients with NHL and targeting LAT1 by JPH203 can be a novel therapeutic modality for NHL.Narangerel JigjidkhorlooKohsuke KanekuraJun MatsubayashiDaigo AkahaneKoji FujitaKeiki OikawaAtsushi KurataMasakatsu TakanashiHitoshi EndouToshitaka NagaoAkihiko GotohOyundelger NorovMasahiko KurodaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Narangerel Jigjidkhorloo Kohsuke Kanekura Jun Matsubayashi Daigo Akahane Koji Fujita Keiki Oikawa Atsushi Kurata Masakatsu Takanashi Hitoshi Endou Toshitaka Nagao Akihiko Gotoh Oyundelger Norov Masahiko Kuroda Expression of L-type amino acid transporter 1 is a poor prognostic factor for Non-Hodgkin’s lymphoma
description	Abstract L-type neutral amino acid transporter 1 (LAT1) is a heterodimeric membrane transport protein involved in neutral amino acid transport. LAT1 is highly expressed in various malignant solid tumors and plays an essential role in cell proliferation. However, its role in malignant lymphoma remains unknown. Here, we evaluated LAT1 expression level in tissues from 138 patients with Non-Hodgkin lymphoma (NHL). Overexpression of LAT1 was confirmed in all types of NHL and we found that there is a significant correlation between the level of LAT1 expression and lymphoma grade. The LAT1 expression was higher in aggressive types of lymphomas when compared with static types of lymphomas, suggesting that active tumor proliferation requires nutrient uptake via LAT1. The expression level of LAT1 was inversely correlated with patients’ survival span. Furthermore, pharmacological inhibition of LAT1 by a specific inhibitor JPH203 inhibits lymphoma cell growth. In conclusion, our study demonstrated that LAT1 expression can be used as a prognostic marker for patients with NHL and targeting LAT1 by JPH203 can be a novel therapeutic modality for NHL.
format	article
author	Narangerel Jigjidkhorloo Kohsuke Kanekura Jun Matsubayashi Daigo Akahane Koji Fujita Keiki Oikawa Atsushi Kurata Masakatsu Takanashi Hitoshi Endou Toshitaka Nagao Akihiko Gotoh Oyundelger Norov Masahiko Kuroda
author_facet	Narangerel Jigjidkhorloo Kohsuke Kanekura Jun Matsubayashi Daigo Akahane Koji Fujita Keiki Oikawa Atsushi Kurata Masakatsu Takanashi Hitoshi Endou Toshitaka Nagao Akihiko Gotoh Oyundelger Norov Masahiko Kuroda
author_sort	Narangerel Jigjidkhorloo
title	Expression of L-type amino acid transporter 1 is a poor prognostic factor for Non-Hodgkin’s lymphoma
title_short	Expression of L-type amino acid transporter 1 is a poor prognostic factor for Non-Hodgkin’s lymphoma
title_full	Expression of L-type amino acid transporter 1 is a poor prognostic factor for Non-Hodgkin’s lymphoma
title_fullStr	Expression of L-type amino acid transporter 1 is a poor prognostic factor for Non-Hodgkin’s lymphoma
title_full_unstemmed	Expression of L-type amino acid transporter 1 is a poor prognostic factor for Non-Hodgkin’s lymphoma
title_sort	expression of l-type amino acid transporter 1 is a poor prognostic factor for non-hodgkin’s lymphoma
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/254f7aaec22f4688a7954b03fd1e965b
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Expression of L-type amino acid transporter 1 is a poor prognostic factor for Non-Hodgkin’s lymphoma

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