Nanomechanics of multidomain neuronal cell adhesion protein contactin revealed by single molecule AFM and SMD

Abstract Contactin-4 (CNTN4) is a complex cell adhesion molecule (CAM) localized at neuronal membranes, playing a key role in maintaining the mechanical integrity and signaling properties of the synapse. CNTN4 consists of six immunoglobulin C2 type (IgC2) domains and four fibronectin type III (FnIII...

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Main Authors: Karolina Mikulska-Ruminska, Andrej J. Kulik, Carine Benadiba, Ivet Bahar, Giovanni Dietler, Wieslaw Nowak
Format: article
Language:EN
Published: Nature Portfolio 2017
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Online Access:https://doaj.org/article/254fe0b9248549b59a53d90c5469c122
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