SAMMY-seq reveals early alteration of heterochromatin and deregulation of bivalent genes in Hutchinson-Gilford Progeria Syndrome

Hutchinson-Gilford progeria syndrome is a genetic disease where an aberrant form of Lamin A disrupts chromatin by interfering with lamina associated domains. Here, the authors present the SAMMY-seq, a method for genome-wide characterization of heterochromatin dynamics and detect early stage alterati...

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Autores principales:	Endre Sebestyén, Fabrizia Marullo, Federica Lucini, Cristiano Petrini, Andrea Bianchi, Sara Valsoni, Ilaria Olivieri, Laura Antonelli, Francesco Gregoretti, Gennaro Oliva, Francesco Ferrari, Chiara Lanzuolo
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/2551c3f1e7794b139aa2db7812391766
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spelling	oai:doaj.org-article:2551c3f1e7794b139aa2db78123917662021-12-02T10:48:19ZSAMMY-seq reveals early alteration of heterochromatin and deregulation of bivalent genes in Hutchinson-Gilford Progeria Syndrome10.1038/s41467-020-20048-92041-1723https://doaj.org/article/2551c3f1e7794b139aa2db78123917662020-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-20048-9https://doaj.org/toc/2041-1723Hutchinson-Gilford progeria syndrome is a genetic disease where an aberrant form of Lamin A disrupts chromatin by interfering with lamina associated domains. Here, the authors present the SAMMY-seq, a method for genome-wide characterization of heterochromatin dynamics and detect early stage alterations of heterochromatin structure in progeria primary fibroblasts, accompained by Polycomb dysfunctions.Endre SebestyénFabrizia MarulloFederica LuciniCristiano PetriniAndrea BianchiSara ValsoniIlaria OlivieriLaura AntonelliFrancesco GregorettiGennaro OlivaFrancesco FerrariChiara LanzuoloNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Endre Sebestyén Fabrizia Marullo Federica Lucini Cristiano Petrini Andrea Bianchi Sara Valsoni Ilaria Olivieri Laura Antonelli Francesco Gregoretti Gennaro Oliva Francesco Ferrari Chiara Lanzuolo SAMMY-seq reveals early alteration of heterochromatin and deregulation of bivalent genes in Hutchinson-Gilford Progeria Syndrome
description	Hutchinson-Gilford progeria syndrome is a genetic disease where an aberrant form of Lamin A disrupts chromatin by interfering with lamina associated domains. Here, the authors present the SAMMY-seq, a method for genome-wide characterization of heterochromatin dynamics and detect early stage alterations of heterochromatin structure in progeria primary fibroblasts, accompained by Polycomb dysfunctions.
format	article
author	Endre Sebestyén Fabrizia Marullo Federica Lucini Cristiano Petrini Andrea Bianchi Sara Valsoni Ilaria Olivieri Laura Antonelli Francesco Gregoretti Gennaro Oliva Francesco Ferrari Chiara Lanzuolo
author_facet	Endre Sebestyén Fabrizia Marullo Federica Lucini Cristiano Petrini Andrea Bianchi Sara Valsoni Ilaria Olivieri Laura Antonelli Francesco Gregoretti Gennaro Oliva Francesco Ferrari Chiara Lanzuolo
author_sort	Endre Sebestyén
title	SAMMY-seq reveals early alteration of heterochromatin and deregulation of bivalent genes in Hutchinson-Gilford Progeria Syndrome
title_short	SAMMY-seq reveals early alteration of heterochromatin and deregulation of bivalent genes in Hutchinson-Gilford Progeria Syndrome
title_full	SAMMY-seq reveals early alteration of heterochromatin and deregulation of bivalent genes in Hutchinson-Gilford Progeria Syndrome
title_fullStr	SAMMY-seq reveals early alteration of heterochromatin and deregulation of bivalent genes in Hutchinson-Gilford Progeria Syndrome
title_full_unstemmed	SAMMY-seq reveals early alteration of heterochromatin and deregulation of bivalent genes in Hutchinson-Gilford Progeria Syndrome
title_sort	sammy-seq reveals early alteration of heterochromatin and deregulation of bivalent genes in hutchinson-gilford progeria syndrome
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/2551c3f1e7794b139aa2db7812391766
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SAMMY-seq reveals early alteration of heterochromatin and deregulation of bivalent genes in Hutchinson-Gilford Progeria Syndrome

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