The molecular mechanisms of ferroptosis and its role in cardiovascular disease

Ferroptosis is a programmed iron-dependent cell death characterized by accumulation of lipid peroxides (LOOH) and redox disequilibrium. Ferroptosis shows unique characteristics in biology, chemistry, and gene levels, compared to other cell death forms. The metabolic disorder of intracellular LOOH ca...

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Autores principales:	Yang Zhang, Laiyun Xin, Mi Xiang, Chang Shang, Yuling Wang, Yan Wang, Xiangning Cui, Yingdong Lu
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2022
Materias:	Ferroptosis Iron Lipid peroxidation GPX4 Cardiovascular diseases Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/255224c97fda464598c3d6bcb2dd36ce
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spelling	oai:doaj.org-article:255224c97fda464598c3d6bcb2dd36ce2021-11-18T04:43:36ZThe molecular mechanisms of ferroptosis and its role in cardiovascular disease0753-332210.1016/j.biopha.2021.112423https://doaj.org/article/255224c97fda464598c3d6bcb2dd36ce2022-01-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S0753332221012099https://doaj.org/toc/0753-3322Ferroptosis is a programmed iron-dependent cell death characterized by accumulation of lipid peroxides (LOOH) and redox disequilibrium. Ferroptosis shows unique characteristics in biology, chemistry, and gene levels, compared to other cell death forms. The metabolic disorder of intracellular LOOH catalyzed by iron causes the inactivity of GPX4, disrupts the redox balance, and triggers cell death. Metabolism of amino acid, iron, and lipid, including associated pathways, is considered as a specific hallmark of ferroptosis. Epidemiological studies and animal experiments have shown that ferroptosis plays an important character in the pathophysiology of cardiovascular disease such as atherosclerosis, myocardial infarction (MI), ischemia/reperfusion (I/R), heart failure (HF), cardiac hypertrophy, cardiomyopathy, and abdominal aortic aneurysm (AAA).This review systematically summarized the latest research progress on the mechanisms of ferroptosis. Then we report the contribution of ferroptosis in cardiovascular diseases. Finally, we discuss and analyze the therapeutic approaches targeting for ferroptosis associated with cardiovascular diseases.Yang ZhangLaiyun XinMi XiangChang ShangYuling WangYan WangXiangning CuiYingdong LuElsevierarticleFerroptosisIronLipid peroxidationGPX4Cardiovascular diseasesTherapeutics. PharmacologyRM1-950ENBiomedicine & Pharmacotherapy, Vol 145, Iss , Pp 112423- (2022)
institution	DOAJ
collection	DOAJ
language	EN
topic	Ferroptosis Iron Lipid peroxidation GPX4 Cardiovascular diseases Therapeutics. Pharmacology RM1-950
spellingShingle	Ferroptosis Iron Lipid peroxidation GPX4 Cardiovascular diseases Therapeutics. Pharmacology RM1-950 Yang Zhang Laiyun Xin Mi Xiang Chang Shang Yuling Wang Yan Wang Xiangning Cui Yingdong Lu The molecular mechanisms of ferroptosis and its role in cardiovascular disease
description	Ferroptosis is a programmed iron-dependent cell death characterized by accumulation of lipid peroxides (LOOH) and redox disequilibrium. Ferroptosis shows unique characteristics in biology, chemistry, and gene levels, compared to other cell death forms. The metabolic disorder of intracellular LOOH catalyzed by iron causes the inactivity of GPX4, disrupts the redox balance, and triggers cell death. Metabolism of amino acid, iron, and lipid, including associated pathways, is considered as a specific hallmark of ferroptosis. Epidemiological studies and animal experiments have shown that ferroptosis plays an important character in the pathophysiology of cardiovascular disease such as atherosclerosis, myocardial infarction (MI), ischemia/reperfusion (I/R), heart failure (HF), cardiac hypertrophy, cardiomyopathy, and abdominal aortic aneurysm (AAA).This review systematically summarized the latest research progress on the mechanisms of ferroptosis. Then we report the contribution of ferroptosis in cardiovascular diseases. Finally, we discuss and analyze the therapeutic approaches targeting for ferroptosis associated with cardiovascular diseases.
format	article
author	Yang Zhang Laiyun Xin Mi Xiang Chang Shang Yuling Wang Yan Wang Xiangning Cui Yingdong Lu
author_facet	Yang Zhang Laiyun Xin Mi Xiang Chang Shang Yuling Wang Yan Wang Xiangning Cui Yingdong Lu
author_sort	Yang Zhang
title	The molecular mechanisms of ferroptosis and its role in cardiovascular disease
title_short	The molecular mechanisms of ferroptosis and its role in cardiovascular disease
title_full	The molecular mechanisms of ferroptosis and its role in cardiovascular disease
title_fullStr	The molecular mechanisms of ferroptosis and its role in cardiovascular disease
title_full_unstemmed	The molecular mechanisms of ferroptosis and its role in cardiovascular disease
title_sort	molecular mechanisms of ferroptosis and its role in cardiovascular disease
publisher	Elsevier
publishDate	2022
url	https://doaj.org/article/255224c97fda464598c3d6bcb2dd36ce
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The molecular mechanisms of ferroptosis and its role in cardiovascular disease

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