Stromal-driven and Amyloid β-dependent induction of neutrophil extracellular traps modulates tumor growth

The tumor microenvironment is composed of many cell types that crosstalk to modulate local immunity. Here the authors show that Amyloid β proteins from cancer-associated fibroblasts (CAF) induce neutrophil extracellular trap (NET) production by neutrophils, while NET feeds back to activate CAF, ther...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Hafsa Munir, James O. Jones, Tobias Janowitz, Markus Hoffmann, Maximilien Euler, Carla P. Martins, Sarah J. Welsh, Jacqueline D. Shields
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/2556fc9e34b0446f9be86ba29dd43111
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:2556fc9e34b0446f9be86ba29dd43111
record_format	dspace
spelling	oai:doaj.org-article:2556fc9e34b0446f9be86ba29dd431112021-12-02T13:57:44ZStromal-driven and Amyloid β-dependent induction of neutrophil extracellular traps modulates tumor growth10.1038/s41467-021-20982-22041-1723https://doaj.org/article/2556fc9e34b0446f9be86ba29dd431112021-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-20982-2https://doaj.org/toc/2041-1723The tumor microenvironment is composed of many cell types that crosstalk to modulate local immunity. Here the authors show that Amyloid β proteins from cancer-associated fibroblasts (CAF) induce neutrophil extracellular trap (NET) production by neutrophils, while NET feeds back to activate CAF, thereby implicating Amyloid β as a potential therapy target.Hafsa MunirJames O. JonesTobias JanowitzMarkus HoffmannMaximilien EulerCarla P. MartinsSarah J. WelshJacqueline D. ShieldsNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Hafsa Munir James O. Jones Tobias Janowitz Markus Hoffmann Maximilien Euler Carla P. Martins Sarah J. Welsh Jacqueline D. Shields Stromal-driven and Amyloid β-dependent induction of neutrophil extracellular traps modulates tumor growth
description	The tumor microenvironment is composed of many cell types that crosstalk to modulate local immunity. Here the authors show that Amyloid β proteins from cancer-associated fibroblasts (CAF) induce neutrophil extracellular trap (NET) production by neutrophils, while NET feeds back to activate CAF, thereby implicating Amyloid β as a potential therapy target.
format	article
author	Hafsa Munir James O. Jones Tobias Janowitz Markus Hoffmann Maximilien Euler Carla P. Martins Sarah J. Welsh Jacqueline D. Shields
author_facet	Hafsa Munir James O. Jones Tobias Janowitz Markus Hoffmann Maximilien Euler Carla P. Martins Sarah J. Welsh Jacqueline D. Shields
author_sort	Hafsa Munir
title	Stromal-driven and Amyloid β-dependent induction of neutrophil extracellular traps modulates tumor growth
title_short	Stromal-driven and Amyloid β-dependent induction of neutrophil extracellular traps modulates tumor growth
title_full	Stromal-driven and Amyloid β-dependent induction of neutrophil extracellular traps modulates tumor growth
title_fullStr	Stromal-driven and Amyloid β-dependent induction of neutrophil extracellular traps modulates tumor growth
title_full_unstemmed	Stromal-driven and Amyloid β-dependent induction of neutrophil extracellular traps modulates tumor growth
title_sort	stromal-driven and amyloid β-dependent induction of neutrophil extracellular traps modulates tumor growth
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/2556fc9e34b0446f9be86ba29dd43111
work_keys_str_mv	AT hafsamunir stromaldrivenandamyloidbdependentinductionofneutrophilextracellulartrapsmodulatestumorgrowth AT jamesojones stromaldrivenandamyloidbdependentinductionofneutrophilextracellulartrapsmodulatestumorgrowth AT tobiasjanowitz stromaldrivenandamyloidbdependentinductionofneutrophilextracellulartrapsmodulatestumorgrowth AT markushoffmann stromaldrivenandamyloidbdependentinductionofneutrophilextracellulartrapsmodulatestumorgrowth AT maximilieneuler stromaldrivenandamyloidbdependentinductionofneutrophilextracellulartrapsmodulatestumorgrowth AT carlapmartins stromaldrivenandamyloidbdependentinductionofneutrophilextracellulartrapsmodulatestumorgrowth AT sarahjwelsh stromaldrivenandamyloidbdependentinductionofneutrophilextracellulartrapsmodulatestumorgrowth AT jacquelinedshields stromaldrivenandamyloidbdependentinductionofneutrophilextracellulartrapsmodulatestumorgrowth
_version_	1718392248442290176

Stromal-driven and Amyloid β-dependent induction of neutrophil extracellular traps modulates tumor growth

Ejemplares similares