Widening the Spaces of Selection: Evolution along Sublethal Antimicrobial Gradients

ABSTRACT The work of Gullberg et al. (E. Gullberg, L. M. Albrecht, C. Karlsson, L. Sandegren, D. I. Andersson, mBio 5:e01918-14, 2014) indicates that extremely low concentrations of antibiotics and heavy metals are able to compensate for the cost of harboring a plasmid encoding resistances to these...

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Autores principales:	Fernando Baquero, Teresa M. Coque
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2014
Materias:	Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/2559c93526a948b49f1dee40e0f5080e
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spelling	oai:doaj.org-article:2559c93526a948b49f1dee40e0f5080e2021-11-15T15:47:04ZWidening the Spaces of Selection: Evolution along Sublethal Antimicrobial Gradients10.1128/mBio.02270-142150-7511https://doaj.org/article/2559c93526a948b49f1dee40e0f5080e2014-12-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mBio.02270-14https://doaj.org/toc/2150-7511ABSTRACT The work of Gullberg et al. (E. Gullberg, L. M. Albrecht, C. Karlsson, L. Sandegren, D. I. Andersson, mBio 5:e01918-14, 2014) indicates that extremely low concentrations of antibiotics and heavy metals are able to compensate for the cost of harboring a plasmid encoding resistances to these inhibitors. Therefore, the “spaces of selection” for plasmids encoding antibiotic or metal resistance along gradients of antimicrobial agents might be huge, and in wide spaces a high number of bacterial cells are exposed to the selective effects. These spaces are even broader if several inhibitors are simultaneously present. Probably very small inhibitor concentrations in the environment, including in sewage and other water bodies, are sufficient to ensure the maintenance and spread of this kind of multiresistance plasmid.Fernando BaqueroTeresa M. CoqueAmerican Society for MicrobiologyarticleMicrobiologyQR1-502ENmBio, Vol 5, Iss 6 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Microbiology QR1-502
spellingShingle	Microbiology QR1-502 Fernando Baquero Teresa M. Coque Widening the Spaces of Selection: Evolution along Sublethal Antimicrobial Gradients
description	ABSTRACT The work of Gullberg et al. (E. Gullberg, L. M. Albrecht, C. Karlsson, L. Sandegren, D. I. Andersson, mBio 5:e01918-14, 2014) indicates that extremely low concentrations of antibiotics and heavy metals are able to compensate for the cost of harboring a plasmid encoding resistances to these inhibitors. Therefore, the “spaces of selection” for plasmids encoding antibiotic or metal resistance along gradients of antimicrobial agents might be huge, and in wide spaces a high number of bacterial cells are exposed to the selective effects. These spaces are even broader if several inhibitors are simultaneously present. Probably very small inhibitor concentrations in the environment, including in sewage and other water bodies, are sufficient to ensure the maintenance and spread of this kind of multiresistance plasmid.
format	article
author	Fernando Baquero Teresa M. Coque
author_facet	Fernando Baquero Teresa M. Coque
author_sort	Fernando Baquero
title	Widening the Spaces of Selection: Evolution along Sublethal Antimicrobial Gradients
title_short	Widening the Spaces of Selection: Evolution along Sublethal Antimicrobial Gradients
title_full	Widening the Spaces of Selection: Evolution along Sublethal Antimicrobial Gradients
title_fullStr	Widening the Spaces of Selection: Evolution along Sublethal Antimicrobial Gradients
title_full_unstemmed	Widening the Spaces of Selection: Evolution along Sublethal Antimicrobial Gradients
title_sort	widening the spaces of selection: evolution along sublethal antimicrobial gradients
publisher	American Society for Microbiology
publishDate	2014
url	https://doaj.org/article/2559c93526a948b49f1dee40e0f5080e
work_keys_str_mv	AT fernandobaquero wideningthespacesofselectionevolutionalongsublethalantimicrobialgradients AT teresamcoque wideningthespacesofselectionevolutionalongsublethalantimicrobialgradients
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Widening the Spaces of Selection: Evolution along Sublethal Antimicrobial Gradients

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