The effect of sex on social cognition and functioning in schizophrenia

Abstract Social cognitive impairment is a core feature of schizophrenia and plays a critical role in poor community functioning in the disorder. However, our understanding of the relationship between key biological variables and social cognitive impairment in schizophrenia is limited. This study exa...

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Autores principales:	Marta Ferrer-Quintero, Michael F. Green, William P. Horan, David L. Penn, Robert S. Kern, Junghee Lee
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Psychiatry RC435-571
Acceso en línea:	https://doaj.org/article/255ce59d75cc40f69b2d9e32eba0633e
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spelling	oai:doaj.org-article:255ce59d75cc40f69b2d9e32eba0633e2021-12-05T12:10:26ZThe effect of sex on social cognition and functioning in schizophrenia10.1038/s41537-021-00188-72334-265Xhttps://doaj.org/article/255ce59d75cc40f69b2d9e32eba0633e2021-12-01T00:00:00Zhttps://doi.org/10.1038/s41537-021-00188-7https://doaj.org/toc/2334-265XAbstract Social cognitive impairment is a core feature of schizophrenia and plays a critical role in poor community functioning in the disorder. However, our understanding of the relationship between key biological variables and social cognitive impairment in schizophrenia is limited. This study examined the effect of sex on the levels of social cognitive impairment and the relationship between social cognitive impairment and social functioning in schizophrenia. Two hundred forty-eight patients with schizophrenia (61 female) and 87 healthy controls (31 female) completed five objective measures and one subjective measure of social cognition. The objective measures included the Facial Affect Identification, Emotion in Biological Motion, Self-Referential Memory, MSCEIT Branch 4, and Empathic Accuracy tasks. The subjective measure was the Interpersonal Reactivity Index (IRI), which includes four subscales. Patients completed measures of social and non-social functional capacity and community functioning. For objective social cognitive tasks, we found a significant sex difference only on one measure, the MSCEIT Branch 4, which in both patient and control groups, females performed better than males. Regarding the IRI, females endorsed higher empathy-related items on one subscale. The moderating role of sex was found only for the association between objective social cognition and non-social functional capacity. The relationship was stronger in male patients than female patients. In this study, we found minimal evidence of a sex effect on social cognition in schizophrenia across subjective and objective measures. Sex does not appear to moderate the association between social cognition and functioning in schizophrenia.Marta Ferrer-QuinteroMichael F. GreenWilliam P. HoranDavid L. PennRobert S. KernJunghee LeeNature PortfolioarticlePsychiatryRC435-571ENnpj Schizophrenia, Vol 7, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Psychiatry RC435-571
spellingShingle	Psychiatry RC435-571 Marta Ferrer-Quintero Michael F. Green William P. Horan David L. Penn Robert S. Kern Junghee Lee The effect of sex on social cognition and functioning in schizophrenia
description	Abstract Social cognitive impairment is a core feature of schizophrenia and plays a critical role in poor community functioning in the disorder. However, our understanding of the relationship between key biological variables and social cognitive impairment in schizophrenia is limited. This study examined the effect of sex on the levels of social cognitive impairment and the relationship between social cognitive impairment and social functioning in schizophrenia. Two hundred forty-eight patients with schizophrenia (61 female) and 87 healthy controls (31 female) completed five objective measures and one subjective measure of social cognition. The objective measures included the Facial Affect Identification, Emotion in Biological Motion, Self-Referential Memory, MSCEIT Branch 4, and Empathic Accuracy tasks. The subjective measure was the Interpersonal Reactivity Index (IRI), which includes four subscales. Patients completed measures of social and non-social functional capacity and community functioning. For objective social cognitive tasks, we found a significant sex difference only on one measure, the MSCEIT Branch 4, which in both patient and control groups, females performed better than males. Regarding the IRI, females endorsed higher empathy-related items on one subscale. The moderating role of sex was found only for the association between objective social cognition and non-social functional capacity. The relationship was stronger in male patients than female patients. In this study, we found minimal evidence of a sex effect on social cognition in schizophrenia across subjective and objective measures. Sex does not appear to moderate the association between social cognition and functioning in schizophrenia.
format	article
author	Marta Ferrer-Quintero Michael F. Green William P. Horan David L. Penn Robert S. Kern Junghee Lee
author_facet	Marta Ferrer-Quintero Michael F. Green William P. Horan David L. Penn Robert S. Kern Junghee Lee
author_sort	Marta Ferrer-Quintero
title	The effect of sex on social cognition and functioning in schizophrenia
title_short	The effect of sex on social cognition and functioning in schizophrenia
title_full	The effect of sex on social cognition and functioning in schizophrenia
title_fullStr	The effect of sex on social cognition and functioning in schizophrenia
title_full_unstemmed	The effect of sex on social cognition and functioning in schizophrenia
title_sort	effect of sex on social cognition and functioning in schizophrenia
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/255ce59d75cc40f69b2d9e32eba0633e
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The effect of sex on social cognition and functioning in schizophrenia

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