Real-time finite element analysis allows homogenization of tissue scale strains and reduces variance in a mouse defect healing model

Abstract Mechanical loading allows both investigation into the mechano-regulation of fracture healing as well as interventions to improve fracture-healing outcomes such as delayed healing or non-unions. However, loading is seldom individualised or even targeted to an effective mechanical stimulus le...

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Autores principales:	Graeme R. Paul, Esther Wehrle, Duncan C. Tourolle, Gisela A. Kuhn, Ralph Müller
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/255dc478dc0a427dbba4fe614620b670
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spelling	oai:doaj.org-article:255dc478dc0a427dbba4fe614620b6702021-12-02T16:10:37ZReal-time finite element analysis allows homogenization of tissue scale strains and reduces variance in a mouse defect healing model10.1038/s41598-021-92961-y2045-2322https://doaj.org/article/255dc478dc0a427dbba4fe614620b6702021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-92961-yhttps://doaj.org/toc/2045-2322Abstract Mechanical loading allows both investigation into the mechano-regulation of fracture healing as well as interventions to improve fracture-healing outcomes such as delayed healing or non-unions. However, loading is seldom individualised or even targeted to an effective mechanical stimulus level within the bone tissue. In this study, we use micro-finite element analysis to demonstrate the result of using a constant loading assumption for all mouse femurs in a given group. We then contrast this with the application of an adaptive loading approach, denoted real time Finite Element adaptation, in which micro-computed tomography images provide the basis for micro-FE based simulations and the resulting strains are manipulated and targeted to a reference distribution. Using this approach, we demonstrate that individualised femoral loading leads to a better-specified strain distribution and lower variance in tissue mechanical stimulus across all mice, both longitudinally and cross-sectionally, while making sure that no overloading is occurring leading to refracture of the femur bones.Graeme R. PaulEsther WehrleDuncan C. TourolleGisela A. KuhnRalph MüllerNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Graeme R. Paul Esther Wehrle Duncan C. Tourolle Gisela A. Kuhn Ralph Müller Real-time finite element analysis allows homogenization of tissue scale strains and reduces variance in a mouse defect healing model
description	Abstract Mechanical loading allows both investigation into the mechano-regulation of fracture healing as well as interventions to improve fracture-healing outcomes such as delayed healing or non-unions. However, loading is seldom individualised or even targeted to an effective mechanical stimulus level within the bone tissue. In this study, we use micro-finite element analysis to demonstrate the result of using a constant loading assumption for all mouse femurs in a given group. We then contrast this with the application of an adaptive loading approach, denoted real time Finite Element adaptation, in which micro-computed tomography images provide the basis for micro-FE based simulations and the resulting strains are manipulated and targeted to a reference distribution. Using this approach, we demonstrate that individualised femoral loading leads to a better-specified strain distribution and lower variance in tissue mechanical stimulus across all mice, both longitudinally and cross-sectionally, while making sure that no overloading is occurring leading to refracture of the femur bones.
format	article
author	Graeme R. Paul Esther Wehrle Duncan C. Tourolle Gisela A. Kuhn Ralph Müller
author_facet	Graeme R. Paul Esther Wehrle Duncan C. Tourolle Gisela A. Kuhn Ralph Müller
author_sort	Graeme R. Paul
title	Real-time finite element analysis allows homogenization of tissue scale strains and reduces variance in a mouse defect healing model
title_short	Real-time finite element analysis allows homogenization of tissue scale strains and reduces variance in a mouse defect healing model
title_full	Real-time finite element analysis allows homogenization of tissue scale strains and reduces variance in a mouse defect healing model
title_fullStr	Real-time finite element analysis allows homogenization of tissue scale strains and reduces variance in a mouse defect healing model
title_full_unstemmed	Real-time finite element analysis allows homogenization of tissue scale strains and reduces variance in a mouse defect healing model
title_sort	real-time finite element analysis allows homogenization of tissue scale strains and reduces variance in a mouse defect healing model
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/255dc478dc0a427dbba4fe614620b670
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Real-time finite element analysis allows homogenization of tissue scale strains and reduces variance in a mouse defect healing model

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