The mechanism of DNA unwinding by the eukaryotic replicative helicase

How the eukaryotic helicase unzips DNA during replication is not well understood. By measuring the real-time motion of purified CMG unwinding DNA with magnetic tweezers, the authors reveal the dynamics where isolated CMG unwinds via a biased random walk with proclivity to pause.

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Auteurs principaux:	Daniel R. Burnham, Hazal B. Kose, Rebecca B. Hoyle, Hasan Yardimci
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2019
Sujets:	Science Q
Accès en ligne:	https://doaj.org/article/256591e3490c4c40b1dfe3c343f18f84
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spelling	oai:doaj.org-article:256591e3490c4c40b1dfe3c343f18f842021-12-02T17:33:23ZThe mechanism of DNA unwinding by the eukaryotic replicative helicase10.1038/s41467-019-09896-22041-1723https://doaj.org/article/256591e3490c4c40b1dfe3c343f18f842019-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09896-2https://doaj.org/toc/2041-1723How the eukaryotic helicase unzips DNA during replication is not well understood. By measuring the real-time motion of purified CMG unwinding DNA with magnetic tweezers, the authors reveal the dynamics where isolated CMG unwinds via a biased random walk with proclivity to pause.Daniel R. BurnhamHazal B. KoseRebecca B. HoyleHasan YardimciNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Daniel R. Burnham Hazal B. Kose Rebecca B. Hoyle Hasan Yardimci The mechanism of DNA unwinding by the eukaryotic replicative helicase
description	How the eukaryotic helicase unzips DNA during replication is not well understood. By measuring the real-time motion of purified CMG unwinding DNA with magnetic tweezers, the authors reveal the dynamics where isolated CMG unwinds via a biased random walk with proclivity to pause.
format	article
author	Daniel R. Burnham Hazal B. Kose Rebecca B. Hoyle Hasan Yardimci
author_facet	Daniel R. Burnham Hazal B. Kose Rebecca B. Hoyle Hasan Yardimci
author_sort	Daniel R. Burnham
title	The mechanism of DNA unwinding by the eukaryotic replicative helicase
title_short	The mechanism of DNA unwinding by the eukaryotic replicative helicase
title_full	The mechanism of DNA unwinding by the eukaryotic replicative helicase
title_fullStr	The mechanism of DNA unwinding by the eukaryotic replicative helicase
title_full_unstemmed	The mechanism of DNA unwinding by the eukaryotic replicative helicase
title_sort	mechanism of dna unwinding by the eukaryotic replicative helicase
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/256591e3490c4c40b1dfe3c343f18f84
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The mechanism of DNA unwinding by the eukaryotic replicative helicase

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