The mechanism of DNA unwinding by the eukaryotic replicative helicase
How the eukaryotic helicase unzips DNA during replication is not well understood. By measuring the real-time motion of purified CMG unwinding DNA with magnetic tweezers, the authors reveal the dynamics where isolated CMG unwinds via a biased random walk with proclivity to pause.
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Autores principales: | Daniel R. Burnham, Hazal B. Kose, Rebecca B. Hoyle, Hasan Yardimci |
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Formato: | article |
Lenguaje: | EN |
Publicado: |
Nature Portfolio
2019
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Materias: | |
Acceso en línea: | https://doaj.org/article/256591e3490c4c40b1dfe3c343f18f84 |
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