The mechanism of DNA unwinding by the eukaryotic replicative helicase

How the eukaryotic helicase unzips DNA during replication is not well understood. By measuring the real-time motion of purified CMG unwinding DNA with magnetic tweezers, the authors reveal the dynamics where isolated CMG unwinds via a biased random walk with proclivity to pause.

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Detalles Bibliográficos
Autores principales: Daniel R. Burnham, Hazal B. Kose, Rebecca B. Hoyle, Hasan Yardimci
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
Materias:
Q
Acceso en línea:https://doaj.org/article/256591e3490c4c40b1dfe3c343f18f84
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