Smart Stimuli-Responsive and Mitochondria Targeting Delivery in Cancer Therapy

Yongjia Huang,1,* Tingting Wang,2,* Qunyou Tan,3,* Dan He,1,* Mingjun Wu,4,* Jingchuan Fan,4 Jie Yang,1 Cailing Zhong,1 Kailing Li,1 Jingqing Zhang1 1Chongqing Research Center for Pharmaceutical Engineering, Chongqing Medical University, Chongqing, People’s Republic of China; 2Biochemistry...

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Autores principales:	Huang Y, Wang T, Tan Q, He D, Wu M, Fan J, Yang J, Zhong C, Li K, Zhang J
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	smart delivery stimuli-responsive mitochondria-targeting tumor microenvironment cancer therapy Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/256928523c0e46c7a628af727cc1abc3
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spelling	oai:doaj.org-article:256928523c0e46c7a628af727cc1abc32021-12-02T14:34:37ZSmart Stimuli-Responsive and Mitochondria Targeting Delivery in Cancer Therapy1178-2013https://doaj.org/article/256928523c0e46c7a628af727cc1abc32021-06-01T00:00:00Zhttps://www.dovepress.com/smart-stimuli-responsive-and-mitochondria-targeting-delivery-in-cancer-peer-reviewed-fulltext-article-IJNhttps://doaj.org/toc/1178-2013Yongjia Huang,1,* Tingting Wang,2,* Qunyou Tan,3,* Dan He,1,* Mingjun Wu,4,* Jingchuan Fan,4 Jie Yang,1 Cailing Zhong,1 Kailing Li,1 Jingqing Zhang1 1Chongqing Research Center for Pharmaceutical Engineering, Chongqing Medical University, Chongqing, People’s Republic of China; 2Biochemistry and Molecular Biology Laboratory, Experimental Teaching and Management Center, Chongqing Medical University, Chongqing, People’s Republic of China; 3Department of Thoracic Surgery, Daping Hospital of Army Medical University, PLA, Chongqing, People’s Republic of China; 4Institute of Life Science, Chongqing Medical University, Chongqing, People’s Republic of China*These authors contributed equally to this workCorrespondence: Jingqing ZhangMedicine Engineering Research Center, Chongqing Medical University, No. 1, Yixueyuan Road, Yuzhong District, Chongqing, People’s Republic of ChinaTel +86 13308300303Email zjqrae01@163.comAbstract: Dysfunction in the mitochondria (Mc) contributes to tumor progression. It is a major challenge to deliver therapeutic agents specifically to the Mc for precise treatment. Smart drug delivery systems are based on stimuli-responsiveness and active targeting. Here, we give a whole list of documented pathways to achieve smart stimuli-responsive (St-) and Mc-targeted DDSs (St-Mc-DDSs) by combining St and Mc targeting strategies. We present the formulations, targeting characteristics of St-Mc-DDSs and clarify their anti-cancer mechanisms as well as improvement in efficacy and safety. St-Mc-DDSs usually not only have Mc-targeting groups, molecules (lipophilic cations, peptides, and aptamers) or materials but also sense the surrounding environment and correspondingly respond to internal biostimulators such as pH, redox changes, enzyme and glucose, and/or externally applied triggers such as light, magnet, temperature and ultrasound. St-Mc-DDSs exquisitely control the action site, increase therapeutic efficacy and decrease side effects of the drug. We summarize the clinical research progress and propose suggestions for follow-up research. St-Mc-DDSs may be an innovative and sensitive precision medicine for cancer treatment.Keywords: smart delivery, stimuli-responsive, mitochondria-targeting, tumor microenvironment, cancer therapyHuang YWang TTan QHe DWu MFan JYang JZhong CLi KZhang JDove Medical Pressarticlesmart deliverystimuli-responsivemitochondria-targetingtumor microenvironmentcancer therapyMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 16, Pp 4117-4146 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	smart delivery stimuli-responsive mitochondria-targeting tumor microenvironment cancer therapy Medicine (General) R5-920
spellingShingle	smart delivery stimuli-responsive mitochondria-targeting tumor microenvironment cancer therapy Medicine (General) R5-920 Huang Y Wang T Tan Q He D Wu M Fan J Yang J Zhong C Li K Zhang J Smart Stimuli-Responsive and Mitochondria Targeting Delivery in Cancer Therapy
description	Yongjia Huang,1,* Tingting Wang,2,* Qunyou Tan,3,* Dan He,1,* Mingjun Wu,4,* Jingchuan Fan,4 Jie Yang,1 Cailing Zhong,1 Kailing Li,1 Jingqing Zhang1 1Chongqing Research Center for Pharmaceutical Engineering, Chongqing Medical University, Chongqing, People’s Republic of China; 2Biochemistry and Molecular Biology Laboratory, Experimental Teaching and Management Center, Chongqing Medical University, Chongqing, People’s Republic of China; 3Department of Thoracic Surgery, Daping Hospital of Army Medical University, PLA, Chongqing, People’s Republic of China; 4Institute of Life Science, Chongqing Medical University, Chongqing, People’s Republic of China*These authors contributed equally to this workCorrespondence: Jingqing ZhangMedicine Engineering Research Center, Chongqing Medical University, No. 1, Yixueyuan Road, Yuzhong District, Chongqing, People’s Republic of ChinaTel +86 13308300303Email zjqrae01@163.comAbstract: Dysfunction in the mitochondria (Mc) contributes to tumor progression. It is a major challenge to deliver therapeutic agents specifically to the Mc for precise treatment. Smart drug delivery systems are based on stimuli-responsiveness and active targeting. Here, we give a whole list of documented pathways to achieve smart stimuli-responsive (St-) and Mc-targeted DDSs (St-Mc-DDSs) by combining St and Mc targeting strategies. We present the formulations, targeting characteristics of St-Mc-DDSs and clarify their anti-cancer mechanisms as well as improvement in efficacy and safety. St-Mc-DDSs usually not only have Mc-targeting groups, molecules (lipophilic cations, peptides, and aptamers) or materials but also sense the surrounding environment and correspondingly respond to internal biostimulators such as pH, redox changes, enzyme and glucose, and/or externally applied triggers such as light, magnet, temperature and ultrasound. St-Mc-DDSs exquisitely control the action site, increase therapeutic efficacy and decrease side effects of the drug. We summarize the clinical research progress and propose suggestions for follow-up research. St-Mc-DDSs may be an innovative and sensitive precision medicine for cancer treatment.Keywords: smart delivery, stimuli-responsive, mitochondria-targeting, tumor microenvironment, cancer therapy
format	article
author	Huang Y Wang T Tan Q He D Wu M Fan J Yang J Zhong C Li K Zhang J
author_facet	Huang Y Wang T Tan Q He D Wu M Fan J Yang J Zhong C Li K Zhang J
author_sort	Huang Y
title	Smart Stimuli-Responsive and Mitochondria Targeting Delivery in Cancer Therapy
title_short	Smart Stimuli-Responsive and Mitochondria Targeting Delivery in Cancer Therapy
title_full	Smart Stimuli-Responsive and Mitochondria Targeting Delivery in Cancer Therapy
title_fullStr	Smart Stimuli-Responsive and Mitochondria Targeting Delivery in Cancer Therapy
title_full_unstemmed	Smart Stimuli-Responsive and Mitochondria Targeting Delivery in Cancer Therapy
title_sort	smart stimuli-responsive and mitochondria targeting delivery in cancer therapy
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/256928523c0e46c7a628af727cc1abc3
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Smart Stimuli-Responsive and Mitochondria Targeting Delivery in Cancer Therapy

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