Early life disease programming during the preconception and prenatal period: making the link between stressful life events and type-1 diabetes.

<h4>Background</h4>To assess the risk of developing Type-1 diabetes among children who were exposed to maternal bereavement during the prenatal or 1-year preconception period.<h4>Methods</h4>We identified N = 1,548,746 singleton births born in Denmark between January 1(st) 19...

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Autores principales:	Jasveer Virk, Jiong Li, Mogens Vestergaard, Carsten Obel, Michael Lu, Jørn Olsen
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2010
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/25698ed9c3bc4aab8187268bae6407ab
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spelling	oai:doaj.org-article:25698ed9c3bc4aab8187268bae6407ab2021-12-02T20:20:11ZEarly life disease programming during the preconception and prenatal period: making the link between stressful life events and type-1 diabetes.1932-620310.1371/journal.pone.0011523https://doaj.org/article/25698ed9c3bc4aab8187268bae6407ab2010-07-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20634978/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>To assess the risk of developing Type-1 diabetes among children who were exposed to maternal bereavement during the prenatal or 1-year preconception period.<h4>Methods</h4>We identified N = 1,548,746 singleton births born in Denmark between January 1(st) 1979 through December 31(st) 2004, and their next of kin. Altogether, 39,857 children were exposed to bereavement during their prenatal life. The main outcome of interest was hospitalization for type-1 diabetes (ICD 8: 249; ICD 10: E10).<h4>Results</h4>We found the strongest association for type-1 diabetes among children exposed to traumatic father or sibling deaths (aIRR: 2.03, 1.22-3.38); the association was mainly seen for girls (aIRR: 2.91, 1.61-5.26).<h4>Conclusions</h4>We found evidence to suggest that female fetuses exposed to severe prenatal stress are at increased risk for developing type-1 diabetes.Jasveer VirkJiong LiJiong LiMogens VestergaardCarsten ObelMichael LuJørn OlsenPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 5, Iss 7, p e11523 (2010)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jasveer Virk Jiong Li Jiong Li Mogens Vestergaard Carsten Obel Michael Lu Jørn Olsen Early life disease programming during the preconception and prenatal period: making the link between stressful life events and type-1 diabetes.
description	<h4>Background</h4>To assess the risk of developing Type-1 diabetes among children who were exposed to maternal bereavement during the prenatal or 1-year preconception period.<h4>Methods</h4>We identified N = 1,548,746 singleton births born in Denmark between January 1(st) 1979 through December 31(st) 2004, and their next of kin. Altogether, 39,857 children were exposed to bereavement during their prenatal life. The main outcome of interest was hospitalization for type-1 diabetes (ICD 8: 249; ICD 10: E10).<h4>Results</h4>We found the strongest association for type-1 diabetes among children exposed to traumatic father or sibling deaths (aIRR: 2.03, 1.22-3.38); the association was mainly seen for girls (aIRR: 2.91, 1.61-5.26).<h4>Conclusions</h4>We found evidence to suggest that female fetuses exposed to severe prenatal stress are at increased risk for developing type-1 diabetes.
format	article
author	Jasveer Virk Jiong Li Jiong Li Mogens Vestergaard Carsten Obel Michael Lu Jørn Olsen
author_facet	Jasveer Virk Jiong Li Jiong Li Mogens Vestergaard Carsten Obel Michael Lu Jørn Olsen
author_sort	Jasveer Virk
title	Early life disease programming during the preconception and prenatal period: making the link between stressful life events and type-1 diabetes.
title_short	Early life disease programming during the preconception and prenatal period: making the link between stressful life events and type-1 diabetes.
title_full	Early life disease programming during the preconception and prenatal period: making the link between stressful life events and type-1 diabetes.
title_fullStr	Early life disease programming during the preconception and prenatal period: making the link between stressful life events and type-1 diabetes.
title_full_unstemmed	Early life disease programming during the preconception and prenatal period: making the link between stressful life events and type-1 diabetes.
title_sort	early life disease programming during the preconception and prenatal period: making the link between stressful life events and type-1 diabetes.
publisher	Public Library of Science (PLoS)
publishDate	2010
url	https://doaj.org/article/25698ed9c3bc4aab8187268bae6407ab
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Early life disease programming during the preconception and prenatal period: making the link between stressful life events and type-1 diabetes.

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