Polymorphic gene markers ILRA and IL2: population distinctions in association with diabetes mellitus

AIMS: In order to study type 1 diabetes mellitus associations, we conducted a comparative analysis of allele and genotype frequencydistribution of polymorphic markers rs41295061 and rs11594656 of IL2RA gene, which encodes α-chain of interleukin-2 receptor, - and rs2069762, a marker of IL2,...

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Autores principales:	Olga Igorevna Kopylova, Tamara Leonidovna Kuraeva, Elena Yur'evna Lavrikova, Elena Vital'evna Titovich, Aleksey Georgievich Nikitin, Valentina Alexandrovna Peterkova, Valery Vyacheslavovich Nosikov, Ivan Ivanovich Dedov
Formato:	article
Lenguaje:	EN RU
Publicado:	Endocrinology Research Centre 2012
Materias:	diabetes mellitus type 1 polymorphic markers rs41295061 rs11594656 gene il2ra rs2069762 il2 Nutritional diseases. Deficiency diseases RC620-627
Acceso en línea:	https://doaj.org/article/256a2a2fdb6542cbbabb6ea78c4e6254
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spelling	oai:doaj.org-article:256a2a2fdb6542cbbabb6ea78c4e62542021-11-14T09:00:17ZPolymorphic gene markers ILRA and IL2: population distinctions in association with diabetes mellitus2072-03512072-037810.14341/2072-0351-5973https://doaj.org/article/256a2a2fdb6542cbbabb6ea78c4e62542012-03-01T00:00:00Zhttps://www.dia-endojournals.ru/jour/article/view/5973https://doaj.org/toc/2072-0351https://doaj.org/toc/2072-0378AIMS: In order to study type 1 diabetes mellitus associations, we conducted a comparative analysis of allele and genotype frequencydistribution of polymorphic markers rs41295061 and rs11594656 of IL2RA gene, which encodes α-chain of interleukin-2 receptor, - and rs2069762, a marker of IL2, gene, encoding interleukin-2. MATERIALS AND METHODS: Experimental group included 451 patients with type 1 diabetes mellitus (DM); control group consistedof 306 healthy subjects (both groups were represented by ethnic Russians). Alleles and polymorphic markers were identified byreal-time amplification method. RESULTS: A comparative analysis of patients with type 1 DM and healthy control group did not show statistically significant differencesfrom the viewpoint of allele and genotype frequency distribution of polymorphic markers rs41295061, rs11594656 and rs2069762. This makes Russian patients considerably different from European ones where markers in question show substantialassociation with type 1 DM. CONCLUSIONS: A comparative analysis of allele and genotype frequency distribution of IL2-RA and IL2 genes polymorphic markersshowed population differences in association of these markers in Russian and European patients.Olga Igorevna KopylovaTamara Leonidovna KuraevaElena Yur'evna LavrikovaElena Vital'evna TitovichAleksey Georgievich NikitinValentina Alexandrovna PeterkovaValery Vyacheslavovich NosikovIvan Ivanovich DedovEndocrinology Research Centrearticlediabetes mellitus type 1polymorphic markersrs41295061rs11594656geneil2rars2069762il2rs41295061rs11594656il2rars2069762il2Nutritional diseases. Deficiency diseasesRC620-627ENRUСахарный диабет, Vol 15, Iss 1, Pp 14-18 (2012)
institution	DOAJ
collection	DOAJ
language	EN RU
topic	diabetes mellitus type 1 polymorphic markers rs41295061 rs11594656 gene il2ra rs2069762 il2 rs41295061 rs11594656 il2ra rs2069762 il2 Nutritional diseases. Deficiency diseases RC620-627
spellingShingle	diabetes mellitus type 1 polymorphic markers rs41295061 rs11594656 gene il2ra rs2069762 il2 rs41295061 rs11594656 il2ra rs2069762 il2 Nutritional diseases. Deficiency diseases RC620-627 Olga Igorevna Kopylova Tamara Leonidovna Kuraeva Elena Yur'evna Lavrikova Elena Vital'evna Titovich Aleksey Georgievich Nikitin Valentina Alexandrovna Peterkova Valery Vyacheslavovich Nosikov Ivan Ivanovich Dedov Polymorphic gene markers ILRA and IL2: population distinctions in association with diabetes mellitus
description	AIMS: In order to study type 1 diabetes mellitus associations, we conducted a comparative analysis of allele and genotype frequencydistribution of polymorphic markers rs41295061 and rs11594656 of IL2RA gene, which encodes α-chain of interleukin-2 receptor, - and rs2069762, a marker of IL2, gene, encoding interleukin-2. MATERIALS AND METHODS: Experimental group included 451 patients with type 1 diabetes mellitus (DM); control group consistedof 306 healthy subjects (both groups were represented by ethnic Russians). Alleles and polymorphic markers were identified byreal-time amplification method. RESULTS: A comparative analysis of patients with type 1 DM and healthy control group did not show statistically significant differencesfrom the viewpoint of allele and genotype frequency distribution of polymorphic markers rs41295061, rs11594656 and rs2069762. This makes Russian patients considerably different from European ones where markers in question show substantialassociation with type 1 DM. CONCLUSIONS: A comparative analysis of allele and genotype frequency distribution of IL2-RA and IL2 genes polymorphic markersshowed population differences in association of these markers in Russian and European patients.
format	article
author	Olga Igorevna Kopylova Tamara Leonidovna Kuraeva Elena Yur'evna Lavrikova Elena Vital'evna Titovich Aleksey Georgievich Nikitin Valentina Alexandrovna Peterkova Valery Vyacheslavovich Nosikov Ivan Ivanovich Dedov
author_facet	Olga Igorevna Kopylova Tamara Leonidovna Kuraeva Elena Yur'evna Lavrikova Elena Vital'evna Titovich Aleksey Georgievich Nikitin Valentina Alexandrovna Peterkova Valery Vyacheslavovich Nosikov Ivan Ivanovich Dedov
author_sort	Olga Igorevna Kopylova
title	Polymorphic gene markers ILRA and IL2: population distinctions in association with diabetes mellitus
title_short	Polymorphic gene markers ILRA and IL2: population distinctions in association with diabetes mellitus
title_full	Polymorphic gene markers ILRA and IL2: population distinctions in association with diabetes mellitus
title_fullStr	Polymorphic gene markers ILRA and IL2: population distinctions in association with diabetes mellitus
title_full_unstemmed	Polymorphic gene markers ILRA and IL2: population distinctions in association with diabetes mellitus
title_sort	polymorphic gene markers ilra and il2: population distinctions in association with diabetes mellitus
publisher	Endocrinology Research Centre
publishDate	2012
url	https://doaj.org/article/256a2a2fdb6542cbbabb6ea78c4e6254
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Polymorphic gene markers ILRA and IL2: population distinctions in association with diabetes mellitus

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