Clinical Effects of Korean Red Ginseng in Postmenopausal Women With Hand Osteoarthritis: A Double-Blind, Randomized Controlled Trial

Background: Although many menopausal Asian women use herbal remedies for joint pain, there are no studies evaluating the efficacy of Korean red ginseng on osteoarthritis symptoms in postmenopausal women. The purpose of this study is to analyze antioxidant enzyme activity, oxidative stress markers, a...

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Autores principales:	Hye In Kim, Seung Joo Chon, Ki Eun Seon, Seok Kyo Seo, Yun-Rak Choi
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	cartilage osteoarthritis pain panax ginseng postmenopausal state randomized controlled trial Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/256c3d39cee0481faf6fcc605f593167
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spelling	oai:doaj.org-article:256c3d39cee0481faf6fcc605f5931672021-11-08T04:52:28ZClinical Effects of Korean Red Ginseng in Postmenopausal Women With Hand Osteoarthritis: A Double-Blind, Randomized Controlled Trial1663-981210.3389/fphar.2021.745568https://doaj.org/article/256c3d39cee0481faf6fcc605f5931672021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fphar.2021.745568/fullhttps://doaj.org/toc/1663-9812Background: Although many menopausal Asian women use herbal remedies for joint pain, there are no studies evaluating the efficacy of Korean red ginseng on osteoarthritis symptoms in postmenopausal women. The purpose of this study is to analyze antioxidant enzyme activity, oxidative stress markers, and pain scores before and after red ginseng consumption, to assess its effect in postmenopausal women. Methods. This prospective, double-blind, randomized controlled trial enrolled 52 postmenopausal women who presented with hand edema and/or pain and were diagnosed as degenerative arthritis of the hand. Patients were randomly assigned to the red ginseng (RG) group (supplemented with 3 g/d of RG for 12 weeks) or the placebo group. Changes in pain and Disability of the Arm, Shoulder, and Hand (DASH) scores, antioxidant enzyme, oxidative stress markers, serum estradiol levels, and endometrial thickness were analyzed. Results. The pain score and DASH score were significantly improved in the RG group (both p < 0.05). The improvement of pain score at rest, during work or sport, and DASH score was significant compared to that of the placebo group. The superoxide dismutase level increased (p < 0.05) and the malondialdehyde level decreased (p < 0.05) significantly in the RG group, while none of the antioxidative factors showed a significant change in the placebo group. Serum estradiol levels and endometrial thickness were not affected by RG supplementation. Conclusion. RG may be an effective dietary supplement for postmenopausal women with degenerative osteoarthritis of the hand. It may relieve pain and improve antioxidative activity without the risk of endometrial thickening.Hye In KimSeung Joo ChonKi Eun SeonSeok Kyo SeoSeok Kyo SeoYun-Rak ChoiFrontiers Media S.A.articlecartilageosteoarthritispainpanax ginsengpostmenopausal staterandomized controlled trialTherapeutics. PharmacologyRM1-950ENFrontiers in Pharmacology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	cartilage osteoarthritis pain panax ginseng postmenopausal state randomized controlled trial Therapeutics. Pharmacology RM1-950
spellingShingle	cartilage osteoarthritis pain panax ginseng postmenopausal state randomized controlled trial Therapeutics. Pharmacology RM1-950 Hye In Kim Seung Joo Chon Ki Eun Seon Seok Kyo Seo Seok Kyo Seo Yun-Rak Choi Clinical Effects of Korean Red Ginseng in Postmenopausal Women With Hand Osteoarthritis: A Double-Blind, Randomized Controlled Trial
description	Background: Although many menopausal Asian women use herbal remedies for joint pain, there are no studies evaluating the efficacy of Korean red ginseng on osteoarthritis symptoms in postmenopausal women. The purpose of this study is to analyze antioxidant enzyme activity, oxidative stress markers, and pain scores before and after red ginseng consumption, to assess its effect in postmenopausal women. Methods. This prospective, double-blind, randomized controlled trial enrolled 52 postmenopausal women who presented with hand edema and/or pain and were diagnosed as degenerative arthritis of the hand. Patients were randomly assigned to the red ginseng (RG) group (supplemented with 3 g/d of RG for 12 weeks) or the placebo group. Changes in pain and Disability of the Arm, Shoulder, and Hand (DASH) scores, antioxidant enzyme, oxidative stress markers, serum estradiol levels, and endometrial thickness were analyzed. Results. The pain score and DASH score were significantly improved in the RG group (both p < 0.05). The improvement of pain score at rest, during work or sport, and DASH score was significant compared to that of the placebo group. The superoxide dismutase level increased (p < 0.05) and the malondialdehyde level decreased (p < 0.05) significantly in the RG group, while none of the antioxidative factors showed a significant change in the placebo group. Serum estradiol levels and endometrial thickness were not affected by RG supplementation. Conclusion. RG may be an effective dietary supplement for postmenopausal women with degenerative osteoarthritis of the hand. It may relieve pain and improve antioxidative activity without the risk of endometrial thickening.
format	article
author	Hye In Kim Seung Joo Chon Ki Eun Seon Seok Kyo Seo Seok Kyo Seo Yun-Rak Choi
author_facet	Hye In Kim Seung Joo Chon Ki Eun Seon Seok Kyo Seo Seok Kyo Seo Yun-Rak Choi
author_sort	Hye In Kim
title	Clinical Effects of Korean Red Ginseng in Postmenopausal Women With Hand Osteoarthritis: A Double-Blind, Randomized Controlled Trial
title_short	Clinical Effects of Korean Red Ginseng in Postmenopausal Women With Hand Osteoarthritis: A Double-Blind, Randomized Controlled Trial
title_full	Clinical Effects of Korean Red Ginseng in Postmenopausal Women With Hand Osteoarthritis: A Double-Blind, Randomized Controlled Trial
title_fullStr	Clinical Effects of Korean Red Ginseng in Postmenopausal Women With Hand Osteoarthritis: A Double-Blind, Randomized Controlled Trial
title_full_unstemmed	Clinical Effects of Korean Red Ginseng in Postmenopausal Women With Hand Osteoarthritis: A Double-Blind, Randomized Controlled Trial
title_sort	clinical effects of korean red ginseng in postmenopausal women with hand osteoarthritis: a double-blind, randomized controlled trial
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/256c3d39cee0481faf6fcc605f593167
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Clinical Effects of Korean Red Ginseng in Postmenopausal Women With Hand Osteoarthritis: A Double-Blind, Randomized Controlled Trial

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