Understanding etiology of chromosome 21 nondisjunction from gene × environment models

Abstract Maternal risk factors and their interactions with each other that associate chromosome 21 nondisjunction are intriguing and need incisive study to be resolved. We determined recombination profile of nondisjoined chromosome 21 and maternal genotypes for four selected polymorphic variants fro...

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Autores principales:	Pinku Halder, Upamanyu Pal, Agnish Ganguly, Papiya Ghosh, Anirban Ray, Sumantra Sarkar, Sujay Ghosh
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/257534e462614476b0f1ec9b3a4da378
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spelling	oai:doaj.org-article:257534e462614476b0f1ec9b3a4da3782021-11-21T12:19:55ZUnderstanding etiology of chromosome 21 nondisjunction from gene × environment models10.1038/s41598-021-01672-x2045-2322https://doaj.org/article/257534e462614476b0f1ec9b3a4da3782021-11-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-01672-xhttps://doaj.org/toc/2045-2322Abstract Maternal risk factors and their interactions with each other that associate chromosome 21 nondisjunction are intriguing and need incisive study to be resolved. We determined recombination profile of nondisjoined chromosome 21 and maternal genotypes for four selected polymorphic variants from the folate regulators genes stratifying the women according to the origin of segregation error and age at conception. We conducted association study for genotype and maternal addiction to smokeless chewing tobacco, usually chopped tobacco leaves or paste of tobacco leaves with the incidence of Down syndrome birth. Additionally, we designed various logistic regression models to explore the effects of maternal genotype, maternal habit of smokeless chewing tobacco, maternal age at conception and all possible interactions among them on chromosome 21 nondisjunction. We found folate regulator gene mutations are associated with maternal meiosis II error. Regression models revealed smokeless chewing tobacco and folate polymorphic/mutant risk genotype interact with each other to increase the risk of reduced and single peri-centromeric recombination events on chromosome 21 that nondisjoined at meiosis II in the oocytes and the effect is maternal age independent. We inferred maternal folate polymorphic/mutant risk genotypes and habit of smokeless chewing tobacco interact with each other and increase the risk of meiosis II error in oocytes in maternal age-independent manner.Pinku HalderUpamanyu PalAgnish GangulyPapiya GhoshAnirban RaySumantra SarkarSujay GhoshNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Pinku Halder Upamanyu Pal Agnish Ganguly Papiya Ghosh Anirban Ray Sumantra Sarkar Sujay Ghosh Understanding etiology of chromosome 21 nondisjunction from gene × environment models
description	Abstract Maternal risk factors and their interactions with each other that associate chromosome 21 nondisjunction are intriguing and need incisive study to be resolved. We determined recombination profile of nondisjoined chromosome 21 and maternal genotypes for four selected polymorphic variants from the folate regulators genes stratifying the women according to the origin of segregation error and age at conception. We conducted association study for genotype and maternal addiction to smokeless chewing tobacco, usually chopped tobacco leaves or paste of tobacco leaves with the incidence of Down syndrome birth. Additionally, we designed various logistic regression models to explore the effects of maternal genotype, maternal habit of smokeless chewing tobacco, maternal age at conception and all possible interactions among them on chromosome 21 nondisjunction. We found folate regulator gene mutations are associated with maternal meiosis II error. Regression models revealed smokeless chewing tobacco and folate polymorphic/mutant risk genotype interact with each other to increase the risk of reduced and single peri-centromeric recombination events on chromosome 21 that nondisjoined at meiosis II in the oocytes and the effect is maternal age independent. We inferred maternal folate polymorphic/mutant risk genotypes and habit of smokeless chewing tobacco interact with each other and increase the risk of meiosis II error in oocytes in maternal age-independent manner.
format	article
author	Pinku Halder Upamanyu Pal Agnish Ganguly Papiya Ghosh Anirban Ray Sumantra Sarkar Sujay Ghosh
author_facet	Pinku Halder Upamanyu Pal Agnish Ganguly Papiya Ghosh Anirban Ray Sumantra Sarkar Sujay Ghosh
author_sort	Pinku Halder
title	Understanding etiology of chromosome 21 nondisjunction from gene × environment models
title_short	Understanding etiology of chromosome 21 nondisjunction from gene × environment models
title_full	Understanding etiology of chromosome 21 nondisjunction from gene × environment models
title_fullStr	Understanding etiology of chromosome 21 nondisjunction from gene × environment models
title_full_unstemmed	Understanding etiology of chromosome 21 nondisjunction from gene × environment models
title_sort	understanding etiology of chromosome 21 nondisjunction from gene × environment models
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/257534e462614476b0f1ec9b3a4da378
work_keys_str_mv	AT pinkuhalder understandingetiologyofchromosome21nondisjunctionfromgeneenvironmentmodels AT upamanyupal understandingetiologyofchromosome21nondisjunctionfromgeneenvironmentmodels AT agnishganguly understandingetiologyofchromosome21nondisjunctionfromgeneenvironmentmodels AT papiyaghosh understandingetiologyofchromosome21nondisjunctionfromgeneenvironmentmodels AT anirbanray understandingetiologyofchromosome21nondisjunctionfromgeneenvironmentmodels AT sumantrasarkar understandingetiologyofchromosome21nondisjunctionfromgeneenvironmentmodels AT sujayghosh understandingetiologyofchromosome21nondisjunctionfromgeneenvironmentmodels
_version_	1718419052708233216

Understanding etiology of chromosome 21 nondisjunction from gene × environment models

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