FEATURES OF SPECIFIC IMMUNE RESPONSE IN THE PATIENTS WITH FIBROUS/CAVERNOUS TUBERCULOSIS OF LUNGS

Abstract. The aim of the present study was to determine the different profiles of the immune responsiveness of the patients with fibro-cavernous pulmonary tuberculosis to PPD from M.tuberculosis in comparison with their response to standart mitogen and IFNγ. A pronounced specific Th1 response was fo...

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Autores principales:	T. E. Kissina, I. S. Freidlin, B. E. Knoring, T. S. Basek, A. B. Elkin
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2014
Materias:	tuberculosis anergy tuberculin cytokines mononuclear cells Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/2575e33c4f7b4fa488c1515a2e87d5fa
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spelling	oai:doaj.org-article:2575e33c4f7b4fa488c1515a2e87d5fa2021-11-18T08:03:41ZFEATURES OF SPECIFIC IMMUNE RESPONSE IN THE PATIENTS WITH FIBROUS/CAVERNOUS TUBERCULOSIS OF LUNGS1563-06252313-741X10.15789/1563-0625-2006-4-501-510https://doaj.org/article/2575e33c4f7b4fa488c1515a2e87d5fa2014-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/462https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XAbstract. The aim of the present study was to determine the different profiles of the immune responsiveness of the patients with fibro-cavernous pulmonary tuberculosis to PPD from M.tuberculosis in comparison with their response to standart mitogen and IFNγ. A pronounced specific Th1 response was found, evidenced by the enhanced proliferation and IL-2 and IFNγ production after contact of their peripheral blood mononuclear cells (PBMCs) with PPD. At the same time a high frequency of PPD-anergy was shown: сonsiderable proportion of TB patients was characterized by low proliferative response to PPD coupled with the low levels of IL-2 and IFNγ. Most of the patients revealed failure of monocyte/macrophage oxidative burst in response to PPD. Additionally a positive correlation was found between the levels of their PBMC’s oxidative burst and IL-4 production.T. E. KissinaI. S. FreidlinB. E. KnoringT. S. BasekA. B. ElkinSPb RAACIarticletuberculosisanergytuberculincytokinesmononuclear cellsImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 8, Iss 4, Pp 501-510 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	tuberculosis anergy tuberculin cytokines mononuclear cells Immunologic diseases. Allergy RC581-607
spellingShingle	tuberculosis anergy tuberculin cytokines mononuclear cells Immunologic diseases. Allergy RC581-607 T. E. Kissina I. S. Freidlin B. E. Knoring T. S. Basek A. B. Elkin FEATURES OF SPECIFIC IMMUNE RESPONSE IN THE PATIENTS WITH FIBROUS/CAVERNOUS TUBERCULOSIS OF LUNGS
description	Abstract. The aim of the present study was to determine the different profiles of the immune responsiveness of the patients with fibro-cavernous pulmonary tuberculosis to PPD from M.tuberculosis in comparison with their response to standart mitogen and IFNγ. A pronounced specific Th1 response was found, evidenced by the enhanced proliferation and IL-2 and IFNγ production after contact of their peripheral blood mononuclear cells (PBMCs) with PPD. At the same time a high frequency of PPD-anergy was shown: сonsiderable proportion of TB patients was characterized by low proliferative response to PPD coupled with the low levels of IL-2 and IFNγ. Most of the patients revealed failure of monocyte/macrophage oxidative burst in response to PPD. Additionally a positive correlation was found between the levels of their PBMC’s oxidative burst and IL-4 production.
format	article
author	T. E. Kissina I. S. Freidlin B. E. Knoring T. S. Basek A. B. Elkin
author_facet	T. E. Kissina I. S. Freidlin B. E. Knoring T. S. Basek A. B. Elkin
author_sort	T. E. Kissina
title	FEATURES OF SPECIFIC IMMUNE RESPONSE IN THE PATIENTS WITH FIBROUS/CAVERNOUS TUBERCULOSIS OF LUNGS
title_short	FEATURES OF SPECIFIC IMMUNE RESPONSE IN THE PATIENTS WITH FIBROUS/CAVERNOUS TUBERCULOSIS OF LUNGS
title_full	FEATURES OF SPECIFIC IMMUNE RESPONSE IN THE PATIENTS WITH FIBROUS/CAVERNOUS TUBERCULOSIS OF LUNGS
title_fullStr	FEATURES OF SPECIFIC IMMUNE RESPONSE IN THE PATIENTS WITH FIBROUS/CAVERNOUS TUBERCULOSIS OF LUNGS
title_full_unstemmed	FEATURES OF SPECIFIC IMMUNE RESPONSE IN THE PATIENTS WITH FIBROUS/CAVERNOUS TUBERCULOSIS OF LUNGS
title_sort	features of specific immune response in the patients with fibrous/cavernous tuberculosis of lungs
publisher	SPb RAACI
publishDate	2014
url	https://doaj.org/article/2575e33c4f7b4fa488c1515a2e87d5fa
work_keys_str_mv	AT tekissina featuresofspecificimmuneresponseinthepatientswithfibrouscavernoustuberculosisoflungs AT isfreidlin featuresofspecificimmuneresponseinthepatientswithfibrouscavernoustuberculosisoflungs AT beknoring featuresofspecificimmuneresponseinthepatientswithfibrouscavernoustuberculosisoflungs AT tsbasek featuresofspecificimmuneresponseinthepatientswithfibrouscavernoustuberculosisoflungs AT abelkin featuresofspecificimmuneresponseinthepatientswithfibrouscavernoustuberculosisoflungs
_version_	1718422468495933440

FEATURES OF SPECIFIC IMMUNE RESPONSE IN THE PATIENTS WITH FIBROUS/CAVERNOUS TUBERCULOSIS OF LUNGS

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