Complete biosynthesis of a sulfated chondroitin in Escherichia coli

Chondroitin sulfate (CS) is a type of sulfated glycosaminoglycan that is manufactured by extraction from animal tissues for the treatment of osteoarthritis and in drug delivery applications. Here, the authors report the development of single microbial cell factories capable of compete, one-step bios...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Abinaya Badri, Asher Williams, Adeola Awofiranye, Payel Datta, Ke Xia, Wenqin He, Keith Fraser, Jonathan S. Dordick, Robert J. Linhardt, Mattheos A. G. Koffas
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/2577cbcebedc48b7b753dd7ad282e97c
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:2577cbcebedc48b7b753dd7ad282e97c
record_format	dspace
spelling	oai:doaj.org-article:2577cbcebedc48b7b753dd7ad282e97c2021-12-02T13:34:29ZComplete biosynthesis of a sulfated chondroitin in Escherichia coli10.1038/s41467-021-21692-52041-1723https://doaj.org/article/2577cbcebedc48b7b753dd7ad282e97c2021-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21692-5https://doaj.org/toc/2041-1723Chondroitin sulfate (CS) is a type of sulfated glycosaminoglycan that is manufactured by extraction from animal tissues for the treatment of osteoarthritis and in drug delivery applications. Here, the authors report the development of single microbial cell factories capable of compete, one-step biosynthesis of animal-free CS production in E. coli.Abinaya BadriAsher WilliamsAdeola AwofiranyePayel DattaKe XiaWenqin HeKeith FraserJonathan S. DordickRobert J. LinhardtMattheos A. G. KoffasNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Abinaya Badri Asher Williams Adeola Awofiranye Payel Datta Ke Xia Wenqin He Keith Fraser Jonathan S. Dordick Robert J. Linhardt Mattheos A. G. Koffas Complete biosynthesis of a sulfated chondroitin in Escherichia coli
description	Chondroitin sulfate (CS) is a type of sulfated glycosaminoglycan that is manufactured by extraction from animal tissues for the treatment of osteoarthritis and in drug delivery applications. Here, the authors report the development of single microbial cell factories capable of compete, one-step biosynthesis of animal-free CS production in E. coli.
format	article
author	Abinaya Badri Asher Williams Adeola Awofiranye Payel Datta Ke Xia Wenqin He Keith Fraser Jonathan S. Dordick Robert J. Linhardt Mattheos A. G. Koffas
author_facet	Abinaya Badri Asher Williams Adeola Awofiranye Payel Datta Ke Xia Wenqin He Keith Fraser Jonathan S. Dordick Robert J. Linhardt Mattheos A. G. Koffas
author_sort	Abinaya Badri
title	Complete biosynthesis of a sulfated chondroitin in Escherichia coli
title_short	Complete biosynthesis of a sulfated chondroitin in Escherichia coli
title_full	Complete biosynthesis of a sulfated chondroitin in Escherichia coli
title_fullStr	Complete biosynthesis of a sulfated chondroitin in Escherichia coli
title_full_unstemmed	Complete biosynthesis of a sulfated chondroitin in Escherichia coli
title_sort	complete biosynthesis of a sulfated chondroitin in escherichia coli
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/2577cbcebedc48b7b753dd7ad282e97c
work_keys_str_mv	AT abinayabadri completebiosynthesisofasulfatedchondroitininescherichiacoli AT asherwilliams completebiosynthesisofasulfatedchondroitininescherichiacoli AT adeolaawofiranye completebiosynthesisofasulfatedchondroitininescherichiacoli AT payeldatta completebiosynthesisofasulfatedchondroitininescherichiacoli AT kexia completebiosynthesisofasulfatedchondroitininescherichiacoli AT wenqinhe completebiosynthesisofasulfatedchondroitininescherichiacoli AT keithfraser completebiosynthesisofasulfatedchondroitininescherichiacoli AT jonathansdordick completebiosynthesisofasulfatedchondroitininescherichiacoli AT robertjlinhardt completebiosynthesisofasulfatedchondroitininescherichiacoli AT mattheosagkoffas completebiosynthesisofasulfatedchondroitininescherichiacoli
_version_	1718392783854632960

Complete biosynthesis of a sulfated chondroitin in Escherichia coli

Ejemplares similares