CSF-contacting neurons regulate locomotion by relaying mechanical stimuli to spinal circuits

CSF-contacting neurons are known to project to locomotor CPGs although their relevance to active locomotion is unclear. Here, the authors show that these cells constitute a mechanosensory organ relying on PKD2L1 channels to detect spinal cord curvature and modulate locomotor frequency in freely movi...

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Autores principales:	Urs Lucas Böhm, Andrew Prendergast, Lydia Djenoune, Sophie Nunes Figueiredo, Johanna Gomez, Caleb Stokes, Sonya Kaiser, Maximilliano Suster, Koichi Kawakami, Marine Charpentier, Jean-Paul Concordet, Jean-Paul Rio, Filippo Del Bene, Claire Wyart
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/25791dd165b94a4e9900651c693643a8
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spelling	oai:doaj.org-article:25791dd165b94a4e9900651c693643a82021-12-02T15:35:45ZCSF-contacting neurons regulate locomotion by relaying mechanical stimuli to spinal circuits10.1038/ncomms108662041-1723https://doaj.org/article/25791dd165b94a4e9900651c693643a82016-03-01T00:00:00Zhttps://doi.org/10.1038/ncomms10866https://doaj.org/toc/2041-1723CSF-contacting neurons are known to project to locomotor CPGs although their relevance to active locomotion is unclear. Here, the authors show that these cells constitute a mechanosensory organ relying on PKD2L1 channels to detect spinal cord curvature and modulate locomotor frequency in freely moving animals.Urs Lucas BöhmAndrew PrendergastLydia DjenouneSophie Nunes FigueiredoJohanna GomezCaleb StokesSonya KaiserMaximilliano SusterKoichi KawakamiMarine CharpentierJean-Paul ConcordetJean-Paul RioFilippo Del BeneClaire WyartNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-8 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Urs Lucas Böhm Andrew Prendergast Lydia Djenoune Sophie Nunes Figueiredo Johanna Gomez Caleb Stokes Sonya Kaiser Maximilliano Suster Koichi Kawakami Marine Charpentier Jean-Paul Concordet Jean-Paul Rio Filippo Del Bene Claire Wyart CSF-contacting neurons regulate locomotion by relaying mechanical stimuli to spinal circuits
description	CSF-contacting neurons are known to project to locomotor CPGs although their relevance to active locomotion is unclear. Here, the authors show that these cells constitute a mechanosensory organ relying on PKD2L1 channels to detect spinal cord curvature and modulate locomotor frequency in freely moving animals.
format	article
author	Urs Lucas Böhm Andrew Prendergast Lydia Djenoune Sophie Nunes Figueiredo Johanna Gomez Caleb Stokes Sonya Kaiser Maximilliano Suster Koichi Kawakami Marine Charpentier Jean-Paul Concordet Jean-Paul Rio Filippo Del Bene Claire Wyart
author_facet	Urs Lucas Böhm Andrew Prendergast Lydia Djenoune Sophie Nunes Figueiredo Johanna Gomez Caleb Stokes Sonya Kaiser Maximilliano Suster Koichi Kawakami Marine Charpentier Jean-Paul Concordet Jean-Paul Rio Filippo Del Bene Claire Wyart
author_sort	Urs Lucas Böhm
title	CSF-contacting neurons regulate locomotion by relaying mechanical stimuli to spinal circuits
title_short	CSF-contacting neurons regulate locomotion by relaying mechanical stimuli to spinal circuits
title_full	CSF-contacting neurons regulate locomotion by relaying mechanical stimuli to spinal circuits
title_fullStr	CSF-contacting neurons regulate locomotion by relaying mechanical stimuli to spinal circuits
title_full_unstemmed	CSF-contacting neurons regulate locomotion by relaying mechanical stimuli to spinal circuits
title_sort	csf-contacting neurons regulate locomotion by relaying mechanical stimuli to spinal circuits
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/25791dd165b94a4e9900651c693643a8
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CSF-contacting neurons regulate locomotion by relaying mechanical stimuli to spinal circuits

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