Interaction of Diet/Lifestyle Intervention and TCF7L2 Genotype on Glycemic Control and Adiposity among Overweight or Obese Adults: Big Data from Seven Randomized Controlled Trials Worldwide

Objective. The strongest locus which associated with type 2 diabetes (T2D) by the common variant rs7903146 is the transcription factor 7-like 2 gene (TCF7L2). We aimed to quantify the interaction of diet/lifestyle interventions and the genetic effect of TCF7L2 rs7903146 on glycemic traits, body weig...

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Autores principales: Tao Huang, Zhenhuang Zhuang, Yoriko Heianza, Dianjianyi Sun, Wenjie Ma, Wenxiu Wang, Meng Gao, Zhe Fang, Emilio Ros, Liana C. Del Gobbo, Jordi Salas-Salvadó, Miguel A. Martínez-González, Jan Polak, Markku Laakso, Arne Astrup, Dominique Langin, Jorg Hager, Gabby Hul, Torben Hansen, Oluf Pedersen, Jean-Michel Oppert, Wim H. M. Saris, Peter Arner, Montserrat Cofán, Sujatha Rajaram, Jaakko Tuomilehto, Jaana Lindström, Vanessa D. de Mello, Alena Stancacova, Matti Uusitupa, Mathilde Svendstrup, Thorkild I. A. Sørensen, Christopher D. Gardner, Joan Sabaté, Dolores Corella, J. Alfredo Martinez, Lu Qi
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Publicado: American Association for the Advancement of Science (AAAS) 2021
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spelling oai:doaj.org-article:257cd713c1e24b03b786b7e3c1019c532021-11-15T08:22:27ZInteraction of Diet/Lifestyle Intervention and TCF7L2 Genotype on Glycemic Control and Adiposity among Overweight or Obese Adults: Big Data from Seven Randomized Controlled Trials Worldwide2765-878310.34133/2021/9897048https://doaj.org/article/257cd713c1e24b03b786b7e3c1019c532021-01-01T00:00:00Zhttp://dx.doi.org/10.34133/2021/9897048https://doaj.org/toc/2765-8783Objective. The strongest locus which associated with type 2 diabetes (T2D) by the common variant rs7903146 is the transcription factor 7-like 2 gene (TCF7L2). We aimed to quantify the interaction of diet/lifestyle interventions and the genetic effect of TCF7L2 rs7903146 on glycemic traits, body weight, or waist circumference in overweight or obese adults in several randomized controlled trials (RCTs). Methods. From October 2016 to May 2018, a large collaborative analysis was performed by pooling individual-participant data from 7 RCTs. These RCTs reported changes in glycemic control and adiposity of the variant rs7903146 after dietary/lifestyle-related interventions in overweight or obese adults. Gene treatment interaction models which used the genetic effect encoded by the allele dose and common covariates were applicable to individual participant data in all studies. Results. In the joint analysis, a total of 7 eligible RCTs were included (n=4,114). Importantly, we observed a significant effect modification of diet/lifestyle-related interventions on the TCF7L2 variant rs7903146 and changes in fasting glucose. Compared with the control group, diet/lifestyle interventions were related to lower fasting glucose by -3.06 (95% CI, -5.77 to -0.36) mg/dL (test for heterogeneity and overall effect: I2=45.1%, p<0.05; z=2.20, p=0.028) per one copy of the TCF7L2 T risk allele. Furthermore, regardless of genetic risk, diet/lifestyle interventions were associated with lower waist circumference. However, there was no significant change for diet/lifestyle interventions in other glycemic control and adiposity traits per one copy of TCF7L2 risk allele. Conclusions. Our findings suggest that carrying the TCF7L2 T risk allele may have a modestly greater benefit for specific diet/lifestyle interventions to improve the control of fasting glucose in overweight or obese adults.Tao HuangZhenhuang ZhuangYoriko HeianzaDianjianyi SunWenjie MaWenxiu WangMeng GaoZhe FangEmilio RosLiana C. Del GobboJordi Salas-Salvad&#x00F3;Miguel A. Mart&#x00ED;nez-Gonz&#x00E1;lezJan PolakMarkku LaaksoArne AstrupDominique LanginJorg HagerGabby HulTorben HansenOluf PedersenJean-Michel OppertWim H. M. SarisPeter ArnerMontserrat Cof&#x00E1;nSujatha RajaramJaakko TuomilehtoJaana Lindstr&#x00F6;mVanessa D. de MelloAlena StancacovaMatti UusitupaMathilde SvendstrupThorkild I. A. S&#x00F8;rensenChristopher D. GardnerJoan Sabat&#x00E9;Dolores CorellaJ. Alfredo MartinezLu QiAmerican Association for the Advancement of Science (AAAS)articleComputer applications to medicine. Medical informaticsR858-859.7ENHealth Data Science, Vol 2021 (2021)
institution DOAJ
collection DOAJ
language EN
topic Computer applications to medicine. Medical informatics
R858-859.7
spellingShingle Computer applications to medicine. Medical informatics
R858-859.7
Tao Huang
Zhenhuang Zhuang
Yoriko Heianza
Dianjianyi Sun
Wenjie Ma
Wenxiu Wang
Meng Gao
Zhe Fang
Emilio Ros
Liana C. Del Gobbo
Jordi Salas-Salvad&#x00F3;
Miguel A. Mart&#x00ED;nez-Gonz&#x00E1;lez
Jan Polak
Markku Laakso
Arne Astrup
Dominique Langin
Jorg Hager
Gabby Hul
Torben Hansen
Oluf Pedersen
Jean-Michel Oppert
Wim H. M. Saris
Peter Arner
Montserrat Cof&#x00E1;n
Sujatha Rajaram
Jaakko Tuomilehto
Jaana Lindstr&#x00F6;m
Vanessa D. de Mello
Alena Stancacova
Matti Uusitupa
Mathilde Svendstrup
Thorkild I. A. S&#x00F8;rensen
Christopher D. Gardner
Joan Sabat&#x00E9;
Dolores Corella
J. Alfredo Martinez
Lu Qi
Interaction of Diet/Lifestyle Intervention and TCF7L2 Genotype on Glycemic Control and Adiposity among Overweight or Obese Adults: Big Data from Seven Randomized Controlled Trials Worldwide
description Objective. The strongest locus which associated with type 2 diabetes (T2D) by the common variant rs7903146 is the transcription factor 7-like 2 gene (TCF7L2). We aimed to quantify the interaction of diet/lifestyle interventions and the genetic effect of TCF7L2 rs7903146 on glycemic traits, body weight, or waist circumference in overweight or obese adults in several randomized controlled trials (RCTs). Methods. From October 2016 to May 2018, a large collaborative analysis was performed by pooling individual-participant data from 7 RCTs. These RCTs reported changes in glycemic control and adiposity of the variant rs7903146 after dietary/lifestyle-related interventions in overweight or obese adults. Gene treatment interaction models which used the genetic effect encoded by the allele dose and common covariates were applicable to individual participant data in all studies. Results. In the joint analysis, a total of 7 eligible RCTs were included (n=4,114). Importantly, we observed a significant effect modification of diet/lifestyle-related interventions on the TCF7L2 variant rs7903146 and changes in fasting glucose. Compared with the control group, diet/lifestyle interventions were related to lower fasting glucose by -3.06 (95% CI, -5.77 to -0.36) mg/dL (test for heterogeneity and overall effect: I2=45.1%, p<0.05; z=2.20, p=0.028) per one copy of the TCF7L2 T risk allele. Furthermore, regardless of genetic risk, diet/lifestyle interventions were associated with lower waist circumference. However, there was no significant change for diet/lifestyle interventions in other glycemic control and adiposity traits per one copy of TCF7L2 risk allele. Conclusions. Our findings suggest that carrying the TCF7L2 T risk allele may have a modestly greater benefit for specific diet/lifestyle interventions to improve the control of fasting glucose in overweight or obese adults.
format article
author Tao Huang
Zhenhuang Zhuang
Yoriko Heianza
Dianjianyi Sun
Wenjie Ma
Wenxiu Wang
Meng Gao
Zhe Fang
Emilio Ros
Liana C. Del Gobbo
Jordi Salas-Salvad&#x00F3;
Miguel A. Mart&#x00ED;nez-Gonz&#x00E1;lez
Jan Polak
Markku Laakso
Arne Astrup
Dominique Langin
Jorg Hager
Gabby Hul
Torben Hansen
Oluf Pedersen
Jean-Michel Oppert
Wim H. M. Saris
Peter Arner
Montserrat Cof&#x00E1;n
Sujatha Rajaram
Jaakko Tuomilehto
Jaana Lindstr&#x00F6;m
Vanessa D. de Mello
Alena Stancacova
Matti Uusitupa
Mathilde Svendstrup
Thorkild I. A. S&#x00F8;rensen
Christopher D. Gardner
Joan Sabat&#x00E9;
Dolores Corella
J. Alfredo Martinez
Lu Qi
author_facet Tao Huang
Zhenhuang Zhuang
Yoriko Heianza
Dianjianyi Sun
Wenjie Ma
Wenxiu Wang
Meng Gao
Zhe Fang
Emilio Ros
Liana C. Del Gobbo
Jordi Salas-Salvad&#x00F3;
Miguel A. Mart&#x00ED;nez-Gonz&#x00E1;lez
Jan Polak
Markku Laakso
Arne Astrup
Dominique Langin
Jorg Hager
Gabby Hul
Torben Hansen
Oluf Pedersen
Jean-Michel Oppert
Wim H. M. Saris
Peter Arner
Montserrat Cof&#x00E1;n
Sujatha Rajaram
Jaakko Tuomilehto
Jaana Lindstr&#x00F6;m
Vanessa D. de Mello
Alena Stancacova
Matti Uusitupa
Mathilde Svendstrup
Thorkild I. A. S&#x00F8;rensen
Christopher D. Gardner
Joan Sabat&#x00E9;
Dolores Corella
J. Alfredo Martinez
Lu Qi
author_sort Tao Huang
title Interaction of Diet/Lifestyle Intervention and TCF7L2 Genotype on Glycemic Control and Adiposity among Overweight or Obese Adults: Big Data from Seven Randomized Controlled Trials Worldwide
title_short Interaction of Diet/Lifestyle Intervention and TCF7L2 Genotype on Glycemic Control and Adiposity among Overweight or Obese Adults: Big Data from Seven Randomized Controlled Trials Worldwide
title_full Interaction of Diet/Lifestyle Intervention and TCF7L2 Genotype on Glycemic Control and Adiposity among Overweight or Obese Adults: Big Data from Seven Randomized Controlled Trials Worldwide
title_fullStr Interaction of Diet/Lifestyle Intervention and TCF7L2 Genotype on Glycemic Control and Adiposity among Overweight or Obese Adults: Big Data from Seven Randomized Controlled Trials Worldwide
title_full_unstemmed Interaction of Diet/Lifestyle Intervention and TCF7L2 Genotype on Glycemic Control and Adiposity among Overweight or Obese Adults: Big Data from Seven Randomized Controlled Trials Worldwide
title_sort interaction of diet/lifestyle intervention and tcf7l2 genotype on glycemic control and adiposity among overweight or obese adults: big data from seven randomized controlled trials worldwide
publisher American Association for the Advancement of Science (AAAS)
publishDate 2021
url https://doaj.org/article/257cd713c1e24b03b786b7e3c1019c53
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