Interaction of Diet/Lifestyle Intervention and TCF7L2 Genotype on Glycemic Control and Adiposity among Overweight or Obese Adults: Big Data from Seven Randomized Controlled Trials Worldwide

Interaction of Diet/Lifestyle Intervention and TCF7L2 Genotype on Glycemic Control and Adiposity among Overweight or Obese Adults: Big Data from Seven Randomized Controlled Trials Worldwide

Objective. The strongest locus which associated with type 2 diabetes (T2D) by the common variant rs7903146 is the transcription factor 7-like 2 gene (TCF7L2). We aimed to quantify the interaction of diet/lifestyle interventions and the genetic effect of TCF7L2 rs7903146 on glycemic traits, body weig...

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Autores principales: Tao Huang, Zhenhuang Zhuang, Yoriko Heianza, Dianjianyi Sun, Wenjie Ma, Wenxiu Wang, Meng Gao, Zhe Fang, Emilio Ros, Liana C. Del Gobbo, Jordi Salas-Salvadó, Miguel A. Martínez-González, Jan Polak, Markku Laakso, Arne Astrup, Dominique Langin, Jorg Hager, Gabby Hul, Torben Hansen, Oluf Pedersen, Jean-Michel Oppert, Wim H. M. Saris, Peter Arner, Montserrat Cofán, Sujatha Rajaram, Jaakko Tuomilehto, Jaana Lindström, Vanessa D. de Mello, Alena Stancacova, Matti Uusitupa, Mathilde Svendstrup, Thorkild I. A. Sørensen, Christopher D. Gardner, Joan Sabaté, Dolores Corella, J. Alfredo Martinez, Lu Qi
Formato: article
Lenguaje:EN
Publicado: American Association for the Advancement of Science (AAAS) 2021
Materias:
Computer applications to medicine. Medical informatics
R858-859.7
Acceso en línea:https://doaj.org/article/257cd713c1e24b03b786b7e3c1019c53
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