Evidence of MHC class I and II influencing viral and helminth infection via the microbiome in a non-human primate

Until recently, the study of major histocompability complex (MHC) mediated immunity has focused on the direct link between MHC diversity and susceptibility to parasite infection. However, MHC genes can also influence host health indirectly through the sculpting of the bacterial community that in tur...

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Autores principales:	B. Karina Montero, Wasimuddin, Nina Schwensow, Mark A. F. Gillingham, Yedidya R. Ratovonamana, S. Jacques Rakotondranary, Victor Corman, Christian Drosten, Jörg U. Ganzhorn, Simone Sommer
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/257fc14d68e8438aa6e506af41d08873
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spelling	oai:doaj.org-article:257fc14d68e8438aa6e506af41d088732021-11-25T05:47:32ZEvidence of MHC class I and II influencing viral and helminth infection via the microbiome in a non-human primate1553-73661553-7374https://doaj.org/article/257fc14d68e8438aa6e506af41d088732021-11-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8601626/?tool=EBIhttps://doaj.org/toc/1553-7366https://doaj.org/toc/1553-7374Until recently, the study of major histocompability complex (MHC) mediated immunity has focused on the direct link between MHC diversity and susceptibility to parasite infection. However, MHC genes can also influence host health indirectly through the sculpting of the bacterial community that in turn shape immune responses. We investigated the links between MHC class I and II gene diversity gut microbiome diversity and micro- (adenovirus, AdV) and macro- (helminth) parasite infection probabilities in a wild population of non-human primates, mouse lemurs of Madagascar. This setup encompasses a plethora of underlying interactions between parasites, microbes and adaptive immunity in natural populations. Both MHC classes explained shifts in microbiome composition and the effect was driven by a few select microbial taxa. Among them were three taxa (Odoribacter, Campylobacter and Prevotellaceae-UCG-001) which were in turn linked to AdV and helminth infection status, correlative evidence of the indirect effect of the MHC via the microbiome. Our study provides support for the coupled role of MHC diversity and microbial flora as contributing factors of parasite infection. Author summary The selective pressure of the major histocompatibility complex (MHC) on microbial communities, and the potential role of this interaction in driving parasite resistance has been largely neglected. Using a natural population of the primate Microcebus griseorufus, we provide correlative evidence of two outstanding findings: that MHCI and MHCII diversity shapes the composition of the gut microbiota; and that select taxa associated with MHC diversity predicted adenovirus and helminth infection status. Our study highlights the importance of incorporating the microbiome when investigating parasite-mediated MHC selection.B. Karina MonteroWasimuddinNina SchwensowMark A. F. GillinghamYedidya R. RatovonamanaS. Jacques RakotondranaryVictor CormanChristian DrostenJörg U. GanzhornSimone SommerPublic Library of Science (PLoS)articleImmunologic diseases. AllergyRC581-607Biology (General)QH301-705.5ENPLoS Pathogens, Vol 17, Iss 11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5
spellingShingle	Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5 B. Karina Montero Wasimuddin Nina Schwensow Mark A. F. Gillingham Yedidya R. Ratovonamana S. Jacques Rakotondranary Victor Corman Christian Drosten Jörg U. Ganzhorn Simone Sommer Evidence of MHC class I and II influencing viral and helminth infection via the microbiome in a non-human primate
description	Until recently, the study of major histocompability complex (MHC) mediated immunity has focused on the direct link between MHC diversity and susceptibility to parasite infection. However, MHC genes can also influence host health indirectly through the sculpting of the bacterial community that in turn shape immune responses. We investigated the links between MHC class I and II gene diversity gut microbiome diversity and micro- (adenovirus, AdV) and macro- (helminth) parasite infection probabilities in a wild population of non-human primates, mouse lemurs of Madagascar. This setup encompasses a plethora of underlying interactions between parasites, microbes and adaptive immunity in natural populations. Both MHC classes explained shifts in microbiome composition and the effect was driven by a few select microbial taxa. Among them were three taxa (Odoribacter, Campylobacter and Prevotellaceae-UCG-001) which were in turn linked to AdV and helminth infection status, correlative evidence of the indirect effect of the MHC via the microbiome. Our study provides support for the coupled role of MHC diversity and microbial flora as contributing factors of parasite infection. Author summary The selective pressure of the major histocompatibility complex (MHC) on microbial communities, and the potential role of this interaction in driving parasite resistance has been largely neglected. Using a natural population of the primate Microcebus griseorufus, we provide correlative evidence of two outstanding findings: that MHCI and MHCII diversity shapes the composition of the gut microbiota; and that select taxa associated with MHC diversity predicted adenovirus and helminth infection status. Our study highlights the importance of incorporating the microbiome when investigating parasite-mediated MHC selection.
format	article
author	B. Karina Montero Wasimuddin Nina Schwensow Mark A. F. Gillingham Yedidya R. Ratovonamana S. Jacques Rakotondranary Victor Corman Christian Drosten Jörg U. Ganzhorn Simone Sommer
author_facet	B. Karina Montero Wasimuddin Nina Schwensow Mark A. F. Gillingham Yedidya R. Ratovonamana S. Jacques Rakotondranary Victor Corman Christian Drosten Jörg U. Ganzhorn Simone Sommer
author_sort	B. Karina Montero
title	Evidence of MHC class I and II influencing viral and helminth infection via the microbiome in a non-human primate
title_short	Evidence of MHC class I and II influencing viral and helminth infection via the microbiome in a non-human primate
title_full	Evidence of MHC class I and II influencing viral and helminth infection via the microbiome in a non-human primate
title_fullStr	Evidence of MHC class I and II influencing viral and helminth infection via the microbiome in a non-human primate
title_full_unstemmed	Evidence of MHC class I and II influencing viral and helminth infection via the microbiome in a non-human primate
title_sort	evidence of mhc class i and ii influencing viral and helminth infection via the microbiome in a non-human primate
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/257fc14d68e8438aa6e506af41d08873
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Evidence of MHC class I and II influencing viral and helminth infection via the microbiome in a non-human primate

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