Circulating stromal cells in resectable pancreatic cancer correlates to pathological stage and predicts for poor clinical outcomes

Abstract Pancreatic cancer (PC) is notoriously difficult to diagnosis and properly stage resulting in incorrect primary treatment. Diagnostic and prognostic biomarkers are desperately needed to more accurately stage patients and select proper treatments. Recently, a newly discovered circulating stro...

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Autores principales:	Kirby P. Gardner, Mohammed Aldakkak, Cha-Mei Tang, Susan Tsai, Daniel L. Adams
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/2584944841bc4ed8b933510f4a3fd00a
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spelling	oai:doaj.org-article:2584944841bc4ed8b933510f4a3fd00a2021-12-02T17:04:54ZCirculating stromal cells in resectable pancreatic cancer correlates to pathological stage and predicts for poor clinical outcomes10.1038/s41698-021-00161-82397-768Xhttps://doaj.org/article/2584944841bc4ed8b933510f4a3fd00a2021-03-01T00:00:00Zhttps://doi.org/10.1038/s41698-021-00161-8https://doaj.org/toc/2397-768XAbstract Pancreatic cancer (PC) is notoriously difficult to diagnosis and properly stage resulting in incorrect primary treatment. Diagnostic and prognostic biomarkers are desperately needed to more accurately stage patients and select proper treatments. Recently, a newly discovered circulating stromal cell, i.e. cancer associated macrophage-like cell (CAML), was found to accurately identify solid cancers and predict for worse prognosis. In this pilot study, blood samples were procured from 63 PC patients prior to start of therapeutic intent. CAMLs were found in 95% of samples tested, with ≥12 CAMLs/7.5 mL and ≥50 µm CAMLs both predicting for advanced pathological stage and progression free survival. These data suggest that CAML assessment prior to treatment of PC predicts patients with under-staged disease and with more aggressive PC less likely to respond to standard of care treatment.Kirby P. GardnerMohammed AldakkakCha-Mei TangSusan TsaiDaniel L. AdamsNature PortfolioarticleNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENnpj Precision Oncology, Vol 5, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Kirby P. Gardner Mohammed Aldakkak Cha-Mei Tang Susan Tsai Daniel L. Adams Circulating stromal cells in resectable pancreatic cancer correlates to pathological stage and predicts for poor clinical outcomes
description	Abstract Pancreatic cancer (PC) is notoriously difficult to diagnosis and properly stage resulting in incorrect primary treatment. Diagnostic and prognostic biomarkers are desperately needed to more accurately stage patients and select proper treatments. Recently, a newly discovered circulating stromal cell, i.e. cancer associated macrophage-like cell (CAML), was found to accurately identify solid cancers and predict for worse prognosis. In this pilot study, blood samples were procured from 63 PC patients prior to start of therapeutic intent. CAMLs were found in 95% of samples tested, with ≥12 CAMLs/7.5 mL and ≥50 µm CAMLs both predicting for advanced pathological stage and progression free survival. These data suggest that CAML assessment prior to treatment of PC predicts patients with under-staged disease and with more aggressive PC less likely to respond to standard of care treatment.
format	article
author	Kirby P. Gardner Mohammed Aldakkak Cha-Mei Tang Susan Tsai Daniel L. Adams
author_facet	Kirby P. Gardner Mohammed Aldakkak Cha-Mei Tang Susan Tsai Daniel L. Adams
author_sort	Kirby P. Gardner
title	Circulating stromal cells in resectable pancreatic cancer correlates to pathological stage and predicts for poor clinical outcomes
title_short	Circulating stromal cells in resectable pancreatic cancer correlates to pathological stage and predicts for poor clinical outcomes
title_full	Circulating stromal cells in resectable pancreatic cancer correlates to pathological stage and predicts for poor clinical outcomes
title_fullStr	Circulating stromal cells in resectable pancreatic cancer correlates to pathological stage and predicts for poor clinical outcomes
title_full_unstemmed	Circulating stromal cells in resectable pancreatic cancer correlates to pathological stage and predicts for poor clinical outcomes
title_sort	circulating stromal cells in resectable pancreatic cancer correlates to pathological stage and predicts for poor clinical outcomes
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/2584944841bc4ed8b933510f4a3fd00a
work_keys_str_mv	AT kirbypgardner circulatingstromalcellsinresectablepancreaticcancercorrelatestopathologicalstageandpredictsforpoorclinicaloutcomes AT mohammedaldakkak circulatingstromalcellsinresectablepancreaticcancercorrelatestopathologicalstageandpredictsforpoorclinicaloutcomes AT chameitang circulatingstromalcellsinresectablepancreaticcancercorrelatestopathologicalstageandpredictsforpoorclinicaloutcomes AT susantsai circulatingstromalcellsinresectablepancreaticcancercorrelatestopathologicalstageandpredictsforpoorclinicaloutcomes AT danielladams circulatingstromalcellsinresectablepancreaticcancercorrelatestopathologicalstageandpredictsforpoorclinicaloutcomes
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Circulating stromal cells in resectable pancreatic cancer correlates to pathological stage and predicts for poor clinical outcomes

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