The aryl hydrocarbon receptor controls cyclin O to promote epithelial multiciliogenesis

Epithelia are barriers against environmental insults and express the transcription factor aryl hydrocarbon receptor (AhR). Here the authors show that AhR regulates multiciliogenesis via cyclin O and Multicilin in a Notch-dependent manner and that this is blocked by toxic ligands.

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Autores principales:	Matteo Villa, Stefania Crotta, Kevin S. Dingwell, Elizabeth M. A. Hirst, Manolis Gialitakis, Helena Ahlfors, James C. Smith, Brigitta Stockinger, Andreas Wack
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/2586c152044d48ffa6ee83a3bf1f6f6c
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spelling	oai:doaj.org-article:2586c152044d48ffa6ee83a3bf1f6f6c2021-12-02T17:31:33ZThe aryl hydrocarbon receptor controls cyclin O to promote epithelial multiciliogenesis10.1038/ncomms126522041-1723https://doaj.org/article/2586c152044d48ffa6ee83a3bf1f6f6c2016-08-01T00:00:00Zhttps://doi.org/10.1038/ncomms12652https://doaj.org/toc/2041-1723Epithelia are barriers against environmental insults and express the transcription factor aryl hydrocarbon receptor (AhR). Here the authors show that AhR regulates multiciliogenesis via cyclin O and Multicilin in a Notch-dependent manner and that this is blocked by toxic ligands.Matteo VillaStefania CrottaKevin S. DingwellElizabeth M. A. HirstManolis GialitakisHelena AhlforsJames C. SmithBrigitta StockingerAndreas WackNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-11 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Matteo Villa Stefania Crotta Kevin S. Dingwell Elizabeth M. A. Hirst Manolis Gialitakis Helena Ahlfors James C. Smith Brigitta Stockinger Andreas Wack The aryl hydrocarbon receptor controls cyclin O to promote epithelial multiciliogenesis
description	Epithelia are barriers against environmental insults and express the transcription factor aryl hydrocarbon receptor (AhR). Here the authors show that AhR regulates multiciliogenesis via cyclin O and Multicilin in a Notch-dependent manner and that this is blocked by toxic ligands.
format	article
author	Matteo Villa Stefania Crotta Kevin S. Dingwell Elizabeth M. A. Hirst Manolis Gialitakis Helena Ahlfors James C. Smith Brigitta Stockinger Andreas Wack
author_facet	Matteo Villa Stefania Crotta Kevin S. Dingwell Elizabeth M. A. Hirst Manolis Gialitakis Helena Ahlfors James C. Smith Brigitta Stockinger Andreas Wack
author_sort	Matteo Villa
title	The aryl hydrocarbon receptor controls cyclin O to promote epithelial multiciliogenesis
title_short	The aryl hydrocarbon receptor controls cyclin O to promote epithelial multiciliogenesis
title_full	The aryl hydrocarbon receptor controls cyclin O to promote epithelial multiciliogenesis
title_fullStr	The aryl hydrocarbon receptor controls cyclin O to promote epithelial multiciliogenesis
title_full_unstemmed	The aryl hydrocarbon receptor controls cyclin O to promote epithelial multiciliogenesis
title_sort	aryl hydrocarbon receptor controls cyclin o to promote epithelial multiciliogenesis
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/2586c152044d48ffa6ee83a3bf1f6f6c
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The aryl hydrocarbon receptor controls cyclin O to promote epithelial multiciliogenesis

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