The aryl hydrocarbon receptor controls cyclin O to promote epithelial multiciliogenesis

The aryl hydrocarbon receptor controls cyclin O to promote epithelial multiciliogenesis

Epithelia are barriers against environmental insults and express the transcription factor aryl hydrocarbon receptor (AhR). Here the authors show that AhR regulates multiciliogenesis via cyclin O and Multicilin in a Notch-dependent manner and that this is blocked by toxic ligands.

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Autores principales: Matteo Villa, Stefania Crotta, Kevin S. Dingwell, Elizabeth M. A. Hirst, Manolis Gialitakis, Helena Ahlfors, James C. Smith, Brigitta Stockinger, Andreas Wack
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
Materias:
Science
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Acceso en línea:https://doaj.org/article/2586c152044d48ffa6ee83a3bf1f6f6c
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