Relationship between genetic polymorphism of drug transporters and the efficacy of Rosuvastatin, atorvastatin and simvastatin in patients with hyperlipidemia

Abstract Background To determine the effect of genetic polymorphism of drug transporters on the efficacy of treatment with Rosuvastatin, Atorvastatin and Simvastatin in patients with hyperlipidemia. Methods The study consists of 180 patients, aged 40–75 years, with hyperlipidemia. All patients were...

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Autores principales: Andrey Sivkov, Natalya Chernus, Roman Gorenkov, Sergey Sivkov, Svetlana Sivkova, Tamara Savina
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Publicado: BMC 2021
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spelling oai:doaj.org-article:258ca855a46d4652a6af528e7261c8d82021-11-14T12:39:50ZRelationship between genetic polymorphism of drug transporters and the efficacy of Rosuvastatin, atorvastatin and simvastatin in patients with hyperlipidemia10.1186/s12944-021-01586-71476-511Xhttps://doaj.org/article/258ca855a46d4652a6af528e7261c8d82021-11-01T00:00:00Zhttps://doi.org/10.1186/s12944-021-01586-7https://doaj.org/toc/1476-511XAbstract Background To determine the effect of genetic polymorphism of drug transporters on the efficacy of treatment with Rosuvastatin, Atorvastatin and Simvastatin in patients with hyperlipidemia. Methods The study consists of 180 patients, aged 40–75 years, with hyperlipidemia. All patients were divided into two equal groups: patients with different SLCO1B1 (521CC, 521CT and 521TT) and MDR1 (3435CC, 3435TC and 3435TT) genotypes. Each group was divided into rosuvastatin-treated, atorvastatin-treated and simvastatin-treated subgroups. The lipid-lowering effect of statins was assessed by tracing changes in total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C) levels. Results The use of statins over a 4-month period led to substantial reductions in TC and LDL-C levels. The hypolipidemic effect of studied agents was seen in both groups. However, it was less pronounced in patients with 521CC genotype. No statistically significantly differences were found between carriers of 3435TT, 3435CT and 3435CC genotypes. Conclusions The lipid-lowering efficacy of rosuvastatin was higher compared to other two statins. Patients with SLCO1B1 521CC genotype are more likely to encounter a decrease in the hypolipidemic effect of statins. Such a risk should be considered when treating this category of patients. MDR1 polymorphism had no significant effect on statin efficacy.Andrey SivkovNatalya ChernusRoman GorenkovSergey SivkovSvetlana SivkovaTamara SavinaBMCarticleCardiovascular diseasesHyperlipidemiaCholesterolLow-density lipoproteinHydroxymethylglutaryl-CoA reductase inhibitorsPharmacogeneticsNutritional diseases. Deficiency diseasesRC620-627ENLipids in Health and Disease, Vol 20, Iss 1, Pp 1-9 (2021)
institution DOAJ
collection DOAJ
language EN
topic Cardiovascular diseases
Hyperlipidemia
Cholesterol
Low-density lipoprotein
Hydroxymethylglutaryl-CoA reductase inhibitors
Pharmacogenetics
Nutritional diseases. Deficiency diseases
RC620-627
spellingShingle Cardiovascular diseases
Hyperlipidemia
Cholesterol
Low-density lipoprotein
Hydroxymethylglutaryl-CoA reductase inhibitors
Pharmacogenetics
Nutritional diseases. Deficiency diseases
RC620-627
Andrey Sivkov
Natalya Chernus
Roman Gorenkov
Sergey Sivkov
Svetlana Sivkova
Tamara Savina
Relationship between genetic polymorphism of drug transporters and the efficacy of Rosuvastatin, atorvastatin and simvastatin in patients with hyperlipidemia
description Abstract Background To determine the effect of genetic polymorphism of drug transporters on the efficacy of treatment with Rosuvastatin, Atorvastatin and Simvastatin in patients with hyperlipidemia. Methods The study consists of 180 patients, aged 40–75 years, with hyperlipidemia. All patients were divided into two equal groups: patients with different SLCO1B1 (521CC, 521CT and 521TT) and MDR1 (3435CC, 3435TC and 3435TT) genotypes. Each group was divided into rosuvastatin-treated, atorvastatin-treated and simvastatin-treated subgroups. The lipid-lowering effect of statins was assessed by tracing changes in total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C) levels. Results The use of statins over a 4-month period led to substantial reductions in TC and LDL-C levels. The hypolipidemic effect of studied agents was seen in both groups. However, it was less pronounced in patients with 521CC genotype. No statistically significantly differences were found between carriers of 3435TT, 3435CT and 3435CC genotypes. Conclusions The lipid-lowering efficacy of rosuvastatin was higher compared to other two statins. Patients with SLCO1B1 521CC genotype are more likely to encounter a decrease in the hypolipidemic effect of statins. Such a risk should be considered when treating this category of patients. MDR1 polymorphism had no significant effect on statin efficacy.
format article
author Andrey Sivkov
Natalya Chernus
Roman Gorenkov
Sergey Sivkov
Svetlana Sivkova
Tamara Savina
author_facet Andrey Sivkov
Natalya Chernus
Roman Gorenkov
Sergey Sivkov
Svetlana Sivkova
Tamara Savina
author_sort Andrey Sivkov
title Relationship between genetic polymorphism of drug transporters and the efficacy of Rosuvastatin, atorvastatin and simvastatin in patients with hyperlipidemia
title_short Relationship between genetic polymorphism of drug transporters and the efficacy of Rosuvastatin, atorvastatin and simvastatin in patients with hyperlipidemia
title_full Relationship between genetic polymorphism of drug transporters and the efficacy of Rosuvastatin, atorvastatin and simvastatin in patients with hyperlipidemia
title_fullStr Relationship between genetic polymorphism of drug transporters and the efficacy of Rosuvastatin, atorvastatin and simvastatin in patients with hyperlipidemia
title_full_unstemmed Relationship between genetic polymorphism of drug transporters and the efficacy of Rosuvastatin, atorvastatin and simvastatin in patients with hyperlipidemia
title_sort relationship between genetic polymorphism of drug transporters and the efficacy of rosuvastatin, atorvastatin and simvastatin in patients with hyperlipidemia
publisher BMC
publishDate 2021
url https://doaj.org/article/258ca855a46d4652a6af528e7261c8d8
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