CD38 Correlates with an Immunosuppressive Treg Phenotype in Lupus-Prone Mice
CD38 is a transmembrane glycoprotein expressed by T-cells. It has been reported that patients with systemic lupus erythematosus (SLE) showed increased CD38<sup>+</sup>CD25<sup>+</sup> T-cells correlating with immune activation and clinical signs. Contrariwise, CD38 deficiency...
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| Autores principales: | , , , , , , , , , |
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| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
MDPI AG
2021
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| Materias: | |
| Acceso en línea: | https://doaj.org/article/258ef1a4062941bc9cf0af1f6c772ade |
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| Sumario: | CD38 is a transmembrane glycoprotein expressed by T-cells. It has been reported that patients with systemic lupus erythematosus (SLE) showed increased CD38<sup>+</sup>CD25<sup>+</sup> T-cells correlating with immune activation and clinical signs. Contrariwise, CD38 deficiency in murine models has shown enhanced autoimmunity development. Recent studies have suggested that CD38<sup>+</sup> regulatory T-cells are more suppressive than CD38<sup>−</sup> regulatory T-cells. Thus, we have suggested that CD38 overexpression in SLE patients could play a role in regulating immune activation cells instead of enhancing it. This study found a correlation between CD38 with FoxP3 expression and immunosuppressive molecules (CD69, IL-10, CTLA-4, and PD-1) in T-cells from lupus-prone mice (B6.MRL-Fas<sup>lpr</sup>/J). Additionally, B6.MRL-Fas<sup>lpr</sup>/J mice showed a decreased proportion of CD38<sup>+</sup> Treg cells regarding wild-type mice (WT). Furthermore, Regulatory T-Cells (Treg cells) from <i>CD38-/-</i> mice showed impairment in expressing immunosuppressive molecules and proliferation after stimulation through the T-cell receptor (TCR). Finally, we demonstrated an increased ratio of IFN-γ/IL-10 secretion in <i>CD38-/-</i> splenocytes stimulated with anti-CD3 compared with the WT. Altogether, our data suggest that CD38 represents an element in maintaining activated and proliferative Treg cells. Consequently, CD38 could have a crucial role in immune tolerance, preventing SLE development through Treg cells. |
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