Structure of ribosome-bound azole-modified peptide phazolicin rationalizes its species-specific mode of bacterial translation inhibition

The authors report the identification of phazolicin (PHZ) - a prokaryotic translation inhibitory peptide - and its structure in complex with the E. coli ribosome, delineating PHZ’s mode of action and suggesting a basis for its bacterial species-specific activity.

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Autores principales:	Dmitrii Y. Travin, Zoe L. Watson, Mikhail Metelev, Fred R. Ward, Ilya A. Osterman, Irina M. Khven, Nelli F. Khabibullina, Marina Serebryakova, Peter Mergaert, Yury S. Polikanov, Jamie H. D. Cate, Konstantin Severinov
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/259172219eaf426fbec6e6c02c364a14
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spelling	oai:doaj.org-article:259172219eaf426fbec6e6c02c364a142021-12-02T15:35:27ZStructure of ribosome-bound azole-modified peptide phazolicin rationalizes its species-specific mode of bacterial translation inhibition10.1038/s41467-019-12589-52041-1723https://doaj.org/article/259172219eaf426fbec6e6c02c364a142019-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12589-5https://doaj.org/toc/2041-1723The authors report the identification of phazolicin (PHZ) - a prokaryotic translation inhibitory peptide - and its structure in complex with the E. coli ribosome, delineating PHZ’s mode of action and suggesting a basis for its bacterial species-specific activity.Dmitrii Y. TravinZoe L. WatsonMikhail MetelevFred R. WardIlya A. OstermanIrina M. KhvenNelli F. KhabibullinaMarina SerebryakovaPeter MergaertYury S. PolikanovJamie H. D. CateKonstantin SeverinovNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Dmitrii Y. Travin Zoe L. Watson Mikhail Metelev Fred R. Ward Ilya A. Osterman Irina M. Khven Nelli F. Khabibullina Marina Serebryakova Peter Mergaert Yury S. Polikanov Jamie H. D. Cate Konstantin Severinov Structure of ribosome-bound azole-modified peptide phazolicin rationalizes its species-specific mode of bacterial translation inhibition
description	The authors report the identification of phazolicin (PHZ) - a prokaryotic translation inhibitory peptide - and its structure in complex with the E. coli ribosome, delineating PHZ’s mode of action and suggesting a basis for its bacterial species-specific activity.
format	article
author	Dmitrii Y. Travin Zoe L. Watson Mikhail Metelev Fred R. Ward Ilya A. Osterman Irina M. Khven Nelli F. Khabibullina Marina Serebryakova Peter Mergaert Yury S. Polikanov Jamie H. D. Cate Konstantin Severinov
author_facet	Dmitrii Y. Travin Zoe L. Watson Mikhail Metelev Fred R. Ward Ilya A. Osterman Irina M. Khven Nelli F. Khabibullina Marina Serebryakova Peter Mergaert Yury S. Polikanov Jamie H. D. Cate Konstantin Severinov
author_sort	Dmitrii Y. Travin
title	Structure of ribosome-bound azole-modified peptide phazolicin rationalizes its species-specific mode of bacterial translation inhibition
title_short	Structure of ribosome-bound azole-modified peptide phazolicin rationalizes its species-specific mode of bacterial translation inhibition
title_full	Structure of ribosome-bound azole-modified peptide phazolicin rationalizes its species-specific mode of bacterial translation inhibition
title_fullStr	Structure of ribosome-bound azole-modified peptide phazolicin rationalizes its species-specific mode of bacterial translation inhibition
title_full_unstemmed	Structure of ribosome-bound azole-modified peptide phazolicin rationalizes its species-specific mode of bacterial translation inhibition
title_sort	structure of ribosome-bound azole-modified peptide phazolicin rationalizes its species-specific mode of bacterial translation inhibition
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/259172219eaf426fbec6e6c02c364a14
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Structure of ribosome-bound azole-modified peptide phazolicin rationalizes its species-specific mode of bacterial translation inhibition

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