Stress-induced alterations of mesocortical and mesolimbic dopaminergic pathways

Abstract Our ability to develop the cognitive strategies required to deal with daily-life stress is regulated by region-specific neuronal networks. Experimental evidence suggests that prolonged stress in mice induces depressive-like behaviors via morphological, functional and molecular changes affec...

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Autores principales:	F. Quessy, T. Bittar, L. J. Blanchette, M. Lévesque, B. Labonté
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/25951ee047ed4c5a885a1dc34c91cdb1
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spelling	oai:doaj.org-article:25951ee047ed4c5a885a1dc34c91cdb12021-12-02T15:49:28ZStress-induced alterations of mesocortical and mesolimbic dopaminergic pathways10.1038/s41598-021-90521-y2045-2322https://doaj.org/article/25951ee047ed4c5a885a1dc34c91cdb12021-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-90521-yhttps://doaj.org/toc/2045-2322Abstract Our ability to develop the cognitive strategies required to deal with daily-life stress is regulated by region-specific neuronal networks. Experimental evidence suggests that prolonged stress in mice induces depressive-like behaviors via morphological, functional and molecular changes affecting the mesolimbic and mesocortical dopaminergic pathways. Yet, the molecular interactions underlying these changes are still poorly understood, and whether they affect males and females similarly is unknown. Here, we used chronic social defeat stress (CSDS) to induce depressive-like behaviors in male and female mice. Density of the mesolimbic and mesocortical projections was assessed via immuno-histochemistry combined with Sholl analysis along with the staining of activity-dependent markers pERK and c-fos in the ventral tegmental area (VTA), nucleus accumbens (NAc) and medial prefrontal cortex (mPFC). Our results show that social stress decreases the density of TH+ dopaminergic axonal projections in the deep layers of the mPFC in susceptible but not resilient male and female mice. Consistently, our analyses suggest that pERK expression is decreased in the mPFC but increased in the NAc following CSDS in males and females, with no change in c-fos expression in both sexes. Overall, our findings indicate that social defeat stress impacts the mesolimbic and mesocortical pathways by altering the molecular interactions regulating somatic and axonal plasticity in males and females.F. QuessyT. BittarL. J. BlanchetteM. LévesqueB. LabontéNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q F. Quessy T. Bittar L. J. Blanchette M. Lévesque B. Labonté Stress-induced alterations of mesocortical and mesolimbic dopaminergic pathways
description	Abstract Our ability to develop the cognitive strategies required to deal with daily-life stress is regulated by region-specific neuronal networks. Experimental evidence suggests that prolonged stress in mice induces depressive-like behaviors via morphological, functional and molecular changes affecting the mesolimbic and mesocortical dopaminergic pathways. Yet, the molecular interactions underlying these changes are still poorly understood, and whether they affect males and females similarly is unknown. Here, we used chronic social defeat stress (CSDS) to induce depressive-like behaviors in male and female mice. Density of the mesolimbic and mesocortical projections was assessed via immuno-histochemistry combined with Sholl analysis along with the staining of activity-dependent markers pERK and c-fos in the ventral tegmental area (VTA), nucleus accumbens (NAc) and medial prefrontal cortex (mPFC). Our results show that social stress decreases the density of TH+ dopaminergic axonal projections in the deep layers of the mPFC in susceptible but not resilient male and female mice. Consistently, our analyses suggest that pERK expression is decreased in the mPFC but increased in the NAc following CSDS in males and females, with no change in c-fos expression in both sexes. Overall, our findings indicate that social defeat stress impacts the mesolimbic and mesocortical pathways by altering the molecular interactions regulating somatic and axonal plasticity in males and females.
format	article
author	F. Quessy T. Bittar L. J. Blanchette M. Lévesque B. Labonté
author_facet	F. Quessy T. Bittar L. J. Blanchette M. Lévesque B. Labonté
author_sort	F. Quessy
title	Stress-induced alterations of mesocortical and mesolimbic dopaminergic pathways
title_short	Stress-induced alterations of mesocortical and mesolimbic dopaminergic pathways
title_full	Stress-induced alterations of mesocortical and mesolimbic dopaminergic pathways
title_fullStr	Stress-induced alterations of mesocortical and mesolimbic dopaminergic pathways
title_full_unstemmed	Stress-induced alterations of mesocortical and mesolimbic dopaminergic pathways
title_sort	stress-induced alterations of mesocortical and mesolimbic dopaminergic pathways
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/25951ee047ed4c5a885a1dc34c91cdb1
work_keys_str_mv	AT fquessy stressinducedalterationsofmesocorticalandmesolimbicdopaminergicpathways AT tbittar stressinducedalterationsofmesocorticalandmesolimbicdopaminergicpathways AT ljblanchette stressinducedalterationsofmesocorticalandmesolimbicdopaminergicpathways AT mlevesque stressinducedalterationsofmesocorticalandmesolimbicdopaminergicpathways AT blabonte stressinducedalterationsofmesocorticalandmesolimbicdopaminergicpathways
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Stress-induced alterations of mesocortical and mesolimbic dopaminergic pathways

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