Biogenesis, functions, and clinical implications of circular RNAs in non-small cell lung cancer

Lung cancer (LC) is the leading cause of cancer-related deaths worldwide, with high morbidity and mortality. Non-small cell lung cancer (NSCLC) is a major pathological type of LC and accounts for more than 80% of all cases. Circular RNAs (circRNAs) are a large class of non-coding RNAs (ncRNAs) with...

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Autores principales:	Ying Liu, Xiang Ao, Wanpeng Yu, Yuan Zhang, Jianxun Wang
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2022
Materias:	circRNA non-small cell lung cancer biogenesis biomarker therapeutic target Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/25971b8de3834a39b7a7fa0fdf2ae6f0
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spelling	oai:doaj.org-article:25971b8de3834a39b7a7fa0fdf2ae6f02021-12-02T05:00:27ZBiogenesis, functions, and clinical implications of circular RNAs in non-small cell lung cancer2162-253110.1016/j.omtn.2021.11.013https://doaj.org/article/25971b8de3834a39b7a7fa0fdf2ae6f02022-03-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2162253121002882https://doaj.org/toc/2162-2531Lung cancer (LC) is the leading cause of cancer-related deaths worldwide, with high morbidity and mortality. Non-small cell lung cancer (NSCLC) is a major pathological type of LC and accounts for more than 80% of all cases. Circular RNAs (circRNAs) are a large class of non-coding RNAs (ncRNAs) with covalently closed-loop structures, a high abundance, and tissue-specific expression patterns. They participate in various pathophysiological processes by regulating complex gene networks involved in proliferation, apoptosis, migration, and epithelial-to-mesenchymal transition (EMT), as well as metastasis. A growing number of studies have revealed that the dysregulation of circRNAs contributes to many aspects of cancer progression, such as its occurrence, metastasis, and recurrence, suggesting their great potential as efficient and specific biomarkers in the diagnosis, prognosis, and therapeutic targeting of NSCLC. In this review, we systematically elucidate the characteristics, biogenesis, and functions of circRNAs and focus on their molecular mechanisms in NSCLC progression. Moreover, we highlight their clinical implications in NSCLC treatment.Ying LiuXiang AoWanpeng YuYuan ZhangJianxun WangElsevierarticlecircRNAnon-small cell lung cancerbiogenesisbiomarkertherapeutic targetTherapeutics. PharmacologyRM1-950ENMolecular Therapy: Nucleic Acids, Vol 27, Iss , Pp 50-72 (2022)
institution	DOAJ
collection	DOAJ
language	EN
topic	circRNA non-small cell lung cancer biogenesis biomarker therapeutic target Therapeutics. Pharmacology RM1-950
spellingShingle	circRNA non-small cell lung cancer biogenesis biomarker therapeutic target Therapeutics. Pharmacology RM1-950 Ying Liu Xiang Ao Wanpeng Yu Yuan Zhang Jianxun Wang Biogenesis, functions, and clinical implications of circular RNAs in non-small cell lung cancer
description	Lung cancer (LC) is the leading cause of cancer-related deaths worldwide, with high morbidity and mortality. Non-small cell lung cancer (NSCLC) is a major pathological type of LC and accounts for more than 80% of all cases. Circular RNAs (circRNAs) are a large class of non-coding RNAs (ncRNAs) with covalently closed-loop structures, a high abundance, and tissue-specific expression patterns. They participate in various pathophysiological processes by regulating complex gene networks involved in proliferation, apoptosis, migration, and epithelial-to-mesenchymal transition (EMT), as well as metastasis. A growing number of studies have revealed that the dysregulation of circRNAs contributes to many aspects of cancer progression, such as its occurrence, metastasis, and recurrence, suggesting their great potential as efficient and specific biomarkers in the diagnosis, prognosis, and therapeutic targeting of NSCLC. In this review, we systematically elucidate the characteristics, biogenesis, and functions of circRNAs and focus on their molecular mechanisms in NSCLC progression. Moreover, we highlight their clinical implications in NSCLC treatment.
format	article
author	Ying Liu Xiang Ao Wanpeng Yu Yuan Zhang Jianxun Wang
author_facet	Ying Liu Xiang Ao Wanpeng Yu Yuan Zhang Jianxun Wang
author_sort	Ying Liu
title	Biogenesis, functions, and clinical implications of circular RNAs in non-small cell lung cancer
title_short	Biogenesis, functions, and clinical implications of circular RNAs in non-small cell lung cancer
title_full	Biogenesis, functions, and clinical implications of circular RNAs in non-small cell lung cancer
title_fullStr	Biogenesis, functions, and clinical implications of circular RNAs in non-small cell lung cancer
title_full_unstemmed	Biogenesis, functions, and clinical implications of circular RNAs in non-small cell lung cancer
title_sort	biogenesis, functions, and clinical implications of circular rnas in non-small cell lung cancer
publisher	Elsevier
publishDate	2022
url	https://doaj.org/article/25971b8de3834a39b7a7fa0fdf2ae6f0
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_version_	1718400818070159360

Biogenesis, functions, and clinical implications of circular RNAs in non-small cell lung cancer

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