Memories in a network with excitatory and inhibitory plasticity are encoded in the spiking irregularity.

Cell assemblies are thought to be the substrate of memory in the brain. Theoretical studies have previously shown that assemblies can be formed in networks with multiple types of plasticity. But how exactly they are formed and how they encode information is yet to be fully understood. One possibilit...

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Auteurs principaux:	Júlia V Gallinaro, Claudia Clopath
Format:	article
Langue:	EN
Publié:	Public Library of Science (PLoS) 2021
Sujets:	Biology (General) QH301-705.5
Accès en ligne:	https://doaj.org/article/2597f723c5824e3f8c81a25c51cc1f2b
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spelling	oai:doaj.org-article:2597f723c5824e3f8c81a25c51cc1f2b2021-12-02T19:58:12ZMemories in a network with excitatory and inhibitory plasticity are encoded in the spiking irregularity.1553-734X1553-735810.1371/journal.pcbi.1009593https://doaj.org/article/2597f723c5824e3f8c81a25c51cc1f2b2021-11-01T00:00:00Zhttps://doi.org/10.1371/journal.pcbi.1009593https://doaj.org/toc/1553-734Xhttps://doaj.org/toc/1553-7358Cell assemblies are thought to be the substrate of memory in the brain. Theoretical studies have previously shown that assemblies can be formed in networks with multiple types of plasticity. But how exactly they are formed and how they encode information is yet to be fully understood. One possibility is that memories are stored in silent assemblies. Here we used a computational model to study the formation of silent assemblies in a network of spiking neurons with excitatory and inhibitory plasticity. We found that even though the formed assemblies were silent in terms of mean firing rate, they had an increased coefficient of variation of inter-spike intervals. We also found that this spiking irregularity could be read out with support of short-term plasticity, and that it could contribute to the longevity of memories.Júlia V GallinaroClaudia ClopathPublic Library of Science (PLoS)articleBiology (General)QH301-705.5ENPLoS Computational Biology, Vol 17, Iss 11, p e1009593 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Júlia V Gallinaro Claudia Clopath Memories in a network with excitatory and inhibitory plasticity are encoded in the spiking irregularity.
description	Cell assemblies are thought to be the substrate of memory in the brain. Theoretical studies have previously shown that assemblies can be formed in networks with multiple types of plasticity. But how exactly they are formed and how they encode information is yet to be fully understood. One possibility is that memories are stored in silent assemblies. Here we used a computational model to study the formation of silent assemblies in a network of spiking neurons with excitatory and inhibitory plasticity. We found that even though the formed assemblies were silent in terms of mean firing rate, they had an increased coefficient of variation of inter-spike intervals. We also found that this spiking irregularity could be read out with support of short-term plasticity, and that it could contribute to the longevity of memories.
format	article
author	Júlia V Gallinaro Claudia Clopath
author_facet	Júlia V Gallinaro Claudia Clopath
author_sort	Júlia V Gallinaro
title	Memories in a network with excitatory and inhibitory plasticity are encoded in the spiking irregularity.
title_short	Memories in a network with excitatory and inhibitory plasticity are encoded in the spiking irregularity.
title_full	Memories in a network with excitatory and inhibitory plasticity are encoded in the spiking irregularity.
title_fullStr	Memories in a network with excitatory and inhibitory plasticity are encoded in the spiking irregularity.
title_full_unstemmed	Memories in a network with excitatory and inhibitory plasticity are encoded in the spiking irregularity.
title_sort	memories in a network with excitatory and inhibitory plasticity are encoded in the spiking irregularity.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/2597f723c5824e3f8c81a25c51cc1f2b
work_keys_str_mv	AT juliavgallinaro memoriesinanetworkwithexcitatoryandinhibitoryplasticityareencodedinthespikingirregularity AT claudiaclopath memoriesinanetworkwithexcitatoryandinhibitoryplasticityareencodedinthespikingirregularity
_version_	1718375767685988352

Memories in a network with excitatory and inhibitory plasticity are encoded in the spiking irregularity.

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