Evaluating the effect of ormeloxifene on multiple fibroadenomas and mastalgia

Introduction: Most common benign breast conditions presenting in the breast clinics include fibroadenomas and mastalgia, both these conditions cause considerable anxiety in the patients. Among other treatment modalities, the hormonal drug treatments are gaining popularity. Ormeloxifene (centchroman)...

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Autores principales:	Swagata Brahmachari, Vaishali Bhagat, Pooja Patil, Vikram Vasuniya
Formato:	article
Lenguaje:	EN
Publicado:	Wolters Kluwer Medknow Publications 2021
Materias:	breast lump centchroman multiple fibroadenoma mastalgia ormeloxifene Pharmacy and materia medica RS1-441 Analytical chemistry QD71-142
Acceso en línea:	https://doaj.org/article/259a319cc27f45b390c666cab39a1d70
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spelling	oai:doaj.org-article:259a319cc27f45b390c666cab39a1d702021-11-19T12:15:53ZEvaluating the effect of ormeloxifene on multiple fibroadenomas and mastalgia0975-740610.4103/jpbs.jpbs_222_21https://doaj.org/article/259a319cc27f45b390c666cab39a1d702021-01-01T00:00:00Zhttp://www.jpbsonline.org/article.asp?issn=0975-7406;year=2021;volume=13;issue=6;spage=1386;epage=1389;aulast=Brahmacharihttps://doaj.org/toc/0975-7406Introduction: Most common benign breast conditions presenting in the breast clinics include fibroadenomas and mastalgia, both these conditions cause considerable anxiety in the patients. Among other treatment modalities, the hormonal drug treatments are gaining popularity. Ormeloxifene (centchroman) is an antiestrogenic drug which is shown to have effect in reducing the pain in mastalgia patients and the size of fibroadenoma. Objectives: Ormeloxifene is selective antiestrogen and a nonsteroidal drug. It has a discerning antiestrogen action and hence is useful for the treatment of mastalgia and multiple small fibroadenomas. Hence, the objective of our study was to assess the effect of Ormeloxifene (centchroman) on multiple fibroadenoma and mastalgia. Materials and Methods: Patients with benign breast disease attending our surgery outpatient department from June 2016 to July 2017. Patients were started on Ormeloxifene 30 mg on alternate days for a period of 3 months. Patients were followed up to 6 months after the inception of the study. Parameters recorded include the Visual Analog Scale (VAS) for pain and ultrasonography for breast lump size. Results: Thirty patients were included in the study. We found very good response in the mastalgia; the VAS scores in these patients dropped from 10 to 3 in 90% in the 1st week of introduction of the drug, and at the end of 1 month, almost all of the patients were painless. Overall final response was noted in terms of complete dissolution and change in the size was noted in 34% partial response in 46 %, no changes in 17 % and increase in size of fibroadenoma was noted in only one case. Conclusion: Novex is proved to be safe drug for the treatment of mastalgia and fibroadenoma. Its results were great in mastalgia group. At the end of 6 months, the number of surgeries (if needed) decrease and there is considerable improvement in the patient satisfaction rate.Swagata BrahmachariVaishali BhagatPooja PatilVikram VasuniyaWolters Kluwer Medknow Publicationsarticlebreast lumpcentchromanmultiple fibroadenomamastalgiaormeloxifenePharmacy and materia medicaRS1-441Analytical chemistryQD71-142ENJournal of Pharmacy and Bioallied Sciences, Vol 13, Iss 6, Pp 1386-1389 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	breast lump centchroman multiple fibroadenoma mastalgia ormeloxifene Pharmacy and materia medica RS1-441 Analytical chemistry QD71-142
spellingShingle	breast lump centchroman multiple fibroadenoma mastalgia ormeloxifene Pharmacy and materia medica RS1-441 Analytical chemistry QD71-142 Swagata Brahmachari Vaishali Bhagat Pooja Patil Vikram Vasuniya Evaluating the effect of ormeloxifene on multiple fibroadenomas and mastalgia
description	Introduction: Most common benign breast conditions presenting in the breast clinics include fibroadenomas and mastalgia, both these conditions cause considerable anxiety in the patients. Among other treatment modalities, the hormonal drug treatments are gaining popularity. Ormeloxifene (centchroman) is an antiestrogenic drug which is shown to have effect in reducing the pain in mastalgia patients and the size of fibroadenoma. Objectives: Ormeloxifene is selective antiestrogen and a nonsteroidal drug. It has a discerning antiestrogen action and hence is useful for the treatment of mastalgia and multiple small fibroadenomas. Hence, the objective of our study was to assess the effect of Ormeloxifene (centchroman) on multiple fibroadenoma and mastalgia. Materials and Methods: Patients with benign breast disease attending our surgery outpatient department from June 2016 to July 2017. Patients were started on Ormeloxifene 30 mg on alternate days for a period of 3 months. Patients were followed up to 6 months after the inception of the study. Parameters recorded include the Visual Analog Scale (VAS) for pain and ultrasonography for breast lump size. Results: Thirty patients were included in the study. We found very good response in the mastalgia; the VAS scores in these patients dropped from 10 to 3 in 90% in the 1st week of introduction of the drug, and at the end of 1 month, almost all of the patients were painless. Overall final response was noted in terms of complete dissolution and change in the size was noted in 34% partial response in 46 %, no changes in 17 % and increase in size of fibroadenoma was noted in only one case. Conclusion: Novex is proved to be safe drug for the treatment of mastalgia and fibroadenoma. Its results were great in mastalgia group. At the end of 6 months, the number of surgeries (if needed) decrease and there is considerable improvement in the patient satisfaction rate.
format	article
author	Swagata Brahmachari Vaishali Bhagat Pooja Patil Vikram Vasuniya
author_facet	Swagata Brahmachari Vaishali Bhagat Pooja Patil Vikram Vasuniya
author_sort	Swagata Brahmachari
title	Evaluating the effect of ormeloxifene on multiple fibroadenomas and mastalgia
title_short	Evaluating the effect of ormeloxifene on multiple fibroadenomas and mastalgia
title_full	Evaluating the effect of ormeloxifene on multiple fibroadenomas and mastalgia
title_fullStr	Evaluating the effect of ormeloxifene on multiple fibroadenomas and mastalgia
title_full_unstemmed	Evaluating the effect of ormeloxifene on multiple fibroadenomas and mastalgia
title_sort	evaluating the effect of ormeloxifene on multiple fibroadenomas and mastalgia
publisher	Wolters Kluwer Medknow Publications
publishDate	2021
url	https://doaj.org/article/259a319cc27f45b390c666cab39a1d70
work_keys_str_mv	AT swagatabrahmachari evaluatingtheeffectoformeloxifeneonmultiplefibroadenomasandmastalgia AT vaishalibhagat evaluatingtheeffectoformeloxifeneonmultiplefibroadenomasandmastalgia AT poojapatil evaluatingtheeffectoformeloxifeneonmultiplefibroadenomasandmastalgia AT vikramvasuniya evaluatingtheeffectoformeloxifeneonmultiplefibroadenomasandmastalgia
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Evaluating the effect of ormeloxifene on multiple fibroadenomas and mastalgia

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