Dysfunction of respiratory system in patients with diabetes mellitus and coronary artery disease

Aims: we aimed to estimate the main parameters characterizing respiratory pulmonary function in patients with isolated type 2 diabetes mellitus (T2DM) and coronary artery disease (CAD), as well as with their combination. Materials and methods: the study included 198 patients divided into 3 groups:...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Evgeny D. Bazdyrev, Olga M. Polikutina, Yulia S. Slepynina, Olga L. Barbarash
Formato:	article
Lenguaje:	EN RU
Publicado:	Endocrinology Research Centre 2018
Materias:	diabetes mellitus coronary artery disease respiratory dysfunction pulmonary function Nutritional diseases. Deficiency diseases RC620-627
Acceso en línea:	https://doaj.org/article/259d32be88b5492a8e492deb4eaf5386
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:259d32be88b5492a8e492deb4eaf5386
record_format	dspace
spelling	oai:doaj.org-article:259d32be88b5492a8e492deb4eaf53862021-11-14T09:00:22ZDysfunction of respiratory system in patients with diabetes mellitus and coronary artery disease2072-03512072-037810.14341/DM9595https://doaj.org/article/259d32be88b5492a8e492deb4eaf53862018-12-01T00:00:00Zhttps://www.dia-endojournals.ru/jour/article/view/9595https://doaj.org/toc/2072-0351https://doaj.org/toc/2072-0378Aims: we aimed to estimate the main parameters characterizing respiratory pulmonary function in patients with isolated type 2 diabetes mellitus (T2DM) and coronary artery disease (CAD), as well as with their combination. Materials and methods: the study included 198 patients divided into 3 groups: I – with isolated CAD [94 (47.5%)], II – with T2DM without the signs of CAD [64 (32.3%)], III – with combined CAD and T2DM [40 (20.2%)]. The assessment of carbohydrate and lipid metabolism, as well as the measurement of inflammatory markers were performed using unified clinical and biochemical methods. Respiratory pulmonary function and diffusion lung capacity (Dlco) were assessed using Elite Dl-220v body plethysmograph. Results: the parameters reflecting the respiratory pulmonary function and the level of gas diffusion through alveolar-capillary membrane (ACM) in patients with CAD both with and without diabetes was within the normal values. The exception was the level of residual volume, which was below the prognostic values in all the studied groups. At the same time, in diabetic patients with CAD the values of forced and slow vital lung capacity, forced expiratory volume for 1-second, as well as the level of diffusion were significantly lower as compared to the corresponding values in patients with isolated CAD and didn’t differ in comparison with the values of diabetic patients except for the level of diffusion. It should be noted that a number of respiratory parameters had a correlation relationships with glycemic level, inflammatory markers and with the indicators characterizing dyslipidemia and myocardial dysfunction. Conclusions: in the course of the study it was found out that the diabetic patients had respiratory system dysfunction in comparison to the patients with isolated CAD. The presence of diabetes in patients with CAD worsens not only the somatic background but probably contributes to the respiratory dysfunction in the form of lower velocity and volumetric parameters, but also in the indicator showing respiratory metabolism.Evgeny D. BazdyrevOlga M. PolikutinaYulia S. SlepyninaOlga L. BarbarashEndocrinology Research Centrearticlediabetes mellituscoronary artery diseaserespiratory dysfunctionpulmonary functionNutritional diseases. Deficiency diseasesRC620-627ENRUСахарный диабет, Vol 21, Iss 6, Pp 480-489 (2018)
institution	DOAJ
collection	DOAJ
language	EN RU
topic	diabetes mellitus coronary artery disease respiratory dysfunction pulmonary function Nutritional diseases. Deficiency diseases RC620-627
spellingShingle	diabetes mellitus coronary artery disease respiratory dysfunction pulmonary function Nutritional diseases. Deficiency diseases RC620-627 Evgeny D. Bazdyrev Olga M. Polikutina Yulia S. Slepynina Olga L. Barbarash Dysfunction of respiratory system in patients with diabetes mellitus and coronary artery disease
description	Aims: we aimed to estimate the main parameters characterizing respiratory pulmonary function in patients with isolated type 2 diabetes mellitus (T2DM) and coronary artery disease (CAD), as well as with their combination. Materials and methods: the study included 198 patients divided into 3 groups: I – with isolated CAD [94 (47.5%)], II – with T2DM without the signs of CAD [64 (32.3%)], III – with combined CAD and T2DM [40 (20.2%)]. The assessment of carbohydrate and lipid metabolism, as well as the measurement of inflammatory markers were performed using unified clinical and biochemical methods. Respiratory pulmonary function and diffusion lung capacity (Dlco) were assessed using Elite Dl-220v body plethysmograph. Results: the parameters reflecting the respiratory pulmonary function and the level of gas diffusion through alveolar-capillary membrane (ACM) in patients with CAD both with and without diabetes was within the normal values. The exception was the level of residual volume, which was below the prognostic values in all the studied groups. At the same time, in diabetic patients with CAD the values of forced and slow vital lung capacity, forced expiratory volume for 1-second, as well as the level of diffusion were significantly lower as compared to the corresponding values in patients with isolated CAD and didn’t differ in comparison with the values of diabetic patients except for the level of diffusion. It should be noted that a number of respiratory parameters had a correlation relationships with glycemic level, inflammatory markers and with the indicators characterizing dyslipidemia and myocardial dysfunction. Conclusions: in the course of the study it was found out that the diabetic patients had respiratory system dysfunction in comparison to the patients with isolated CAD. The presence of diabetes in patients with CAD worsens not only the somatic background but probably contributes to the respiratory dysfunction in the form of lower velocity and volumetric parameters, but also in the indicator showing respiratory metabolism.
format	article
author	Evgeny D. Bazdyrev Olga M. Polikutina Yulia S. Slepynina Olga L. Barbarash
author_facet	Evgeny D. Bazdyrev Olga M. Polikutina Yulia S. Slepynina Olga L. Barbarash
author_sort	Evgeny D. Bazdyrev
title	Dysfunction of respiratory system in patients with diabetes mellitus and coronary artery disease
title_short	Dysfunction of respiratory system in patients with diabetes mellitus and coronary artery disease
title_full	Dysfunction of respiratory system in patients with diabetes mellitus and coronary artery disease
title_fullStr	Dysfunction of respiratory system in patients with diabetes mellitus and coronary artery disease
title_full_unstemmed	Dysfunction of respiratory system in patients with diabetes mellitus and coronary artery disease
title_sort	dysfunction of respiratory system in patients with diabetes mellitus and coronary artery disease
publisher	Endocrinology Research Centre
publishDate	2018
url	https://doaj.org/article/259d32be88b5492a8e492deb4eaf5386
work_keys_str_mv	AT evgenydbazdyrev dysfunctionofrespiratorysysteminpatientswithdiabetesmellitusandcoronaryarterydisease AT olgampolikutina dysfunctionofrespiratorysysteminpatientswithdiabetesmellitusandcoronaryarterydisease AT yuliasslepynina dysfunctionofrespiratorysysteminpatientswithdiabetesmellitusandcoronaryarterydisease AT olgalbarbarash dysfunctionofrespiratorysysteminpatientswithdiabetesmellitusandcoronaryarterydisease
_version_	1718429513664167936

Dysfunction of respiratory system in patients with diabetes mellitus and coronary artery disease

Ejemplares similares