Investigation of the removal mechanism of antibiotic ceftazidime by green algae and subsequent microbic impact assessment

Abstract The present study provides an integrated view of algal removal of the antibiotic ceftazidime and its basic parent structure 7-aminocephalosporanic acid (7-ACA), including contribution analysis, bacteriostatic and aquatic toxic assessment and metabolite verification. 92.70% and 96.07% of the...

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Autores principales:	Ying Yu, Yangyang Zhou, Zhiliang Wang, Oscar Lopez Torres, Ruixin Guo, Jianqiu Chen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/259e0faa7543427fbdb915ca930e9915
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spelling	oai:doaj.org-article:259e0faa7543427fbdb915ca930e99152021-12-02T15:05:37ZInvestigation of the removal mechanism of antibiotic ceftazidime by green algae and subsequent microbic impact assessment10.1038/s41598-017-04128-32045-2322https://doaj.org/article/259e0faa7543427fbdb915ca930e99152017-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-04128-3https://doaj.org/toc/2045-2322Abstract The present study provides an integrated view of algal removal of the antibiotic ceftazidime and its basic parent structure 7-aminocephalosporanic acid (7-ACA), including contribution analysis, bacteriostatic and aquatic toxic assessment and metabolite verification. 92.70% and 96.07% of the two target compounds was removed after the algal treatment, respectively. The algal removal can be separated into three steps: a rapid adsorption, a slow cell wall-transmission and the final biodegradation. Additionally, while ceftazidime demonstrated an excellent inhibitory effect on Escherichia coli, there was no bacteriostasis introduced after the algal treatment, which could avoid favoring the harmful selective pressure. On the other hand, no significant aquatic impact of the two target compounds on rotifers was observed and it was not enhanced after the algal treatment. To better reveal the mechanism involved, metabolite analyses were performed. Δ-3 ceftazidime and trans-ceftazidime were regarded as the metabolites of ceftazidime and the metabolite of 7-ACA was regarded as a compound which shared the similar structure with 4-chlorocinnamic acid. Our study indicated that the green algae performed a satisfactory growth capacity and played a dominant role for the biodegradation of the target antibiotics, which achieved high removal efficiency and low environmental impact.Ying YuYangyang ZhouZhiliang WangOscar Lopez TorresRuixin GuoJianqiu ChenNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ying Yu Yangyang Zhou Zhiliang Wang Oscar Lopez Torres Ruixin Guo Jianqiu Chen Investigation of the removal mechanism of antibiotic ceftazidime by green algae and subsequent microbic impact assessment
description	Abstract The present study provides an integrated view of algal removal of the antibiotic ceftazidime and its basic parent structure 7-aminocephalosporanic acid (7-ACA), including contribution analysis, bacteriostatic and aquatic toxic assessment and metabolite verification. 92.70% and 96.07% of the two target compounds was removed after the algal treatment, respectively. The algal removal can be separated into three steps: a rapid adsorption, a slow cell wall-transmission and the final biodegradation. Additionally, while ceftazidime demonstrated an excellent inhibitory effect on Escherichia coli, there was no bacteriostasis introduced after the algal treatment, which could avoid favoring the harmful selective pressure. On the other hand, no significant aquatic impact of the two target compounds on rotifers was observed and it was not enhanced after the algal treatment. To better reveal the mechanism involved, metabolite analyses were performed. Δ-3 ceftazidime and trans-ceftazidime were regarded as the metabolites of ceftazidime and the metabolite of 7-ACA was regarded as a compound which shared the similar structure with 4-chlorocinnamic acid. Our study indicated that the green algae performed a satisfactory growth capacity and played a dominant role for the biodegradation of the target antibiotics, which achieved high removal efficiency and low environmental impact.
format	article
author	Ying Yu Yangyang Zhou Zhiliang Wang Oscar Lopez Torres Ruixin Guo Jianqiu Chen
author_facet	Ying Yu Yangyang Zhou Zhiliang Wang Oscar Lopez Torres Ruixin Guo Jianqiu Chen
author_sort	Ying Yu
title	Investigation of the removal mechanism of antibiotic ceftazidime by green algae and subsequent microbic impact assessment
title_short	Investigation of the removal mechanism of antibiotic ceftazidime by green algae and subsequent microbic impact assessment
title_full	Investigation of the removal mechanism of antibiotic ceftazidime by green algae and subsequent microbic impact assessment
title_fullStr	Investigation of the removal mechanism of antibiotic ceftazidime by green algae and subsequent microbic impact assessment
title_full_unstemmed	Investigation of the removal mechanism of antibiotic ceftazidime by green algae and subsequent microbic impact assessment
title_sort	investigation of the removal mechanism of antibiotic ceftazidime by green algae and subsequent microbic impact assessment
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/259e0faa7543427fbdb915ca930e9915
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Investigation of the removal mechanism of antibiotic ceftazidime by green algae and subsequent microbic impact assessment

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