Stimulation of zona incerta selectively modulates pain in humans

Abstract Stimulation of zona incerta in rodent models has been shown to modulate behavioral reactions to noxious stimuli. Sensory changes observed in Parkinsonian patients with subthalamic deep brain stimulation suggest that this effect is translatable to humans. Here, we utilized the serendipitous...

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Autores principales:	Charles W. Lu, Daniel E. Harper, Asra Askari, Matthew S. Willsey, Philip P. Vu, Andrew D. Schrepf, Steven E. Harte, Parag G. Patil
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/259f8de9b942497a97a1fcb979c20935
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spelling	oai:doaj.org-article:259f8de9b942497a97a1fcb979c209352021-12-02T16:56:03ZStimulation of zona incerta selectively modulates pain in humans10.1038/s41598-021-87873-w2045-2322https://doaj.org/article/259f8de9b942497a97a1fcb979c209352021-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-87873-whttps://doaj.org/toc/2045-2322Abstract Stimulation of zona incerta in rodent models has been shown to modulate behavioral reactions to noxious stimuli. Sensory changes observed in Parkinsonian patients with subthalamic deep brain stimulation suggest that this effect is translatable to humans. Here, we utilized the serendipitous placement of subthalamic deep brain stimulation leads in 6 + 5 Parkinsonian patients to directly investigate the effects of zona incerta stimulation on human pain perception. We found that stimulation at 20 Hz, the physiological firing frequency of zona incerta, reduces experimental heat pain by a modest but significant amount, achieving a 30% reduction in one fifth of implants. Stimulation at higher frequencies did not modulate heat pain. Modulation was selective for heat pain and was not observed for warmth perception or pressure pain. These findings provide a mechanistic explanation of sensory changes seen in subthalamic deep brain stimulation patients and identify zona incerta as a potential target for neuromodulation of pain.Charles W. LuDaniel E. HarperAsra AskariMatthew S. WillseyPhilip P. VuAndrew D. SchrepfSteven E. HarteParag G. PatilNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Charles W. Lu Daniel E. Harper Asra Askari Matthew S. Willsey Philip P. Vu Andrew D. Schrepf Steven E. Harte Parag G. Patil Stimulation of zona incerta selectively modulates pain in humans
description	Abstract Stimulation of zona incerta in rodent models has been shown to modulate behavioral reactions to noxious stimuli. Sensory changes observed in Parkinsonian patients with subthalamic deep brain stimulation suggest that this effect is translatable to humans. Here, we utilized the serendipitous placement of subthalamic deep brain stimulation leads in 6 + 5 Parkinsonian patients to directly investigate the effects of zona incerta stimulation on human pain perception. We found that stimulation at 20 Hz, the physiological firing frequency of zona incerta, reduces experimental heat pain by a modest but significant amount, achieving a 30% reduction in one fifth of implants. Stimulation at higher frequencies did not modulate heat pain. Modulation was selective for heat pain and was not observed for warmth perception or pressure pain. These findings provide a mechanistic explanation of sensory changes seen in subthalamic deep brain stimulation patients and identify zona incerta as a potential target for neuromodulation of pain.
format	article
author	Charles W. Lu Daniel E. Harper Asra Askari Matthew S. Willsey Philip P. Vu Andrew D. Schrepf Steven E. Harte Parag G. Patil
author_facet	Charles W. Lu Daniel E. Harper Asra Askari Matthew S. Willsey Philip P. Vu Andrew D. Schrepf Steven E. Harte Parag G. Patil
author_sort	Charles W. Lu
title	Stimulation of zona incerta selectively modulates pain in humans
title_short	Stimulation of zona incerta selectively modulates pain in humans
title_full	Stimulation of zona incerta selectively modulates pain in humans
title_fullStr	Stimulation of zona incerta selectively modulates pain in humans
title_full_unstemmed	Stimulation of zona incerta selectively modulates pain in humans
title_sort	stimulation of zona incerta selectively modulates pain in humans
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/259f8de9b942497a97a1fcb979c20935
work_keys_str_mv	AT charleswlu stimulationofzonaincertaselectivelymodulatespaininhumans AT danieleharper stimulationofzonaincertaselectivelymodulatespaininhumans AT asraaskari stimulationofzonaincertaselectivelymodulatespaininhumans AT matthewswillsey stimulationofzonaincertaselectivelymodulatespaininhumans AT philippvu stimulationofzonaincertaselectivelymodulatespaininhumans AT andrewdschrepf stimulationofzonaincertaselectivelymodulatespaininhumans AT steveneharte stimulationofzonaincertaselectivelymodulatespaininhumans AT paraggpatil stimulationofzonaincertaselectivelymodulatespaininhumans
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Stimulation of zona incerta selectively modulates pain in humans

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