HMGA2 promotes vasculogenic mimicry and tumor aggressiveness by upregulating Twist1 in gastric carcinoma

Abstract High mobility group protein A2 (HMGA2) is a transcription factor that plays an important role in the invasion and metastasis of gastric carcinoma (GC). The term vasculogenic mimicry (VM) refers to the unique ability of aggressive tumour cells to mimic the pattern of embryonic vasculogenic n...

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Autores principales:	Junying Sun, Baocun Sun, Ran Sun, Dongwang Zhu, Xiulan Zhao, Yanhui Zhang, Xueyi Dong, Na Che, Jing Li, Fang Liu, Nan Zhao, Yong Wang, Danfang Zhang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/25a02bb7c79c4b7284c4da67e5884972
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spelling	oai:doaj.org-article:25a02bb7c79c4b7284c4da67e58849722021-12-02T15:05:22ZHMGA2 promotes vasculogenic mimicry and tumor aggressiveness by upregulating Twist1 in gastric carcinoma10.1038/s41598-017-02494-62045-2322https://doaj.org/article/25a02bb7c79c4b7284c4da67e58849722017-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-02494-6https://doaj.org/toc/2045-2322Abstract High mobility group protein A2 (HMGA2) is a transcription factor that plays an important role in the invasion and metastasis of gastric carcinoma (GC). The term vasculogenic mimicry (VM) refers to the unique ability of aggressive tumour cells to mimic the pattern of embryonic vasculogenic networks. However, the relationship between HMGA2 and VM formation remains unclear. In the present study, we examined concomitant HMGA2 expression and VM in 228 human GC samples and 4 GC cell lines. Our data indicate that HMGA2 is not only significantly associated with VM formation but also influences the prognosis of patients with gastric carcinoma. Overexpression of HMGA2 significantly increased cell motility, invasiveness, and VM formation both in vitro and in vivo. A luciferase reporter assay, Co-IP and ChIP demonstrated that HMGA2 induced the expression of Twist1 and VE-cadherin by binding to the Twist1 promoter. Moreover, we observed a decrease in VE-cadherin following Twist1 knockdown in cells overexpressing HMGA2. This study indicates that HMGA2 promotes VM in GC via Twist1-VE-cadherin signalling and influences the prognosis of patients with GC.Junying SunBaocun SunRan SunDongwang ZhuXiulan ZhaoYanhui ZhangXueyi DongNa CheJing LiFang LiuNan ZhaoYong WangDanfang ZhangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Junying Sun Baocun Sun Ran Sun Dongwang Zhu Xiulan Zhao Yanhui Zhang Xueyi Dong Na Che Jing Li Fang Liu Nan Zhao Yong Wang Danfang Zhang HMGA2 promotes vasculogenic mimicry and tumor aggressiveness by upregulating Twist1 in gastric carcinoma
description	Abstract High mobility group protein A2 (HMGA2) is a transcription factor that plays an important role in the invasion and metastasis of gastric carcinoma (GC). The term vasculogenic mimicry (VM) refers to the unique ability of aggressive tumour cells to mimic the pattern of embryonic vasculogenic networks. However, the relationship between HMGA2 and VM formation remains unclear. In the present study, we examined concomitant HMGA2 expression and VM in 228 human GC samples and 4 GC cell lines. Our data indicate that HMGA2 is not only significantly associated with VM formation but also influences the prognosis of patients with gastric carcinoma. Overexpression of HMGA2 significantly increased cell motility, invasiveness, and VM formation both in vitro and in vivo. A luciferase reporter assay, Co-IP and ChIP demonstrated that HMGA2 induced the expression of Twist1 and VE-cadherin by binding to the Twist1 promoter. Moreover, we observed a decrease in VE-cadherin following Twist1 knockdown in cells overexpressing HMGA2. This study indicates that HMGA2 promotes VM in GC via Twist1-VE-cadherin signalling and influences the prognosis of patients with GC.
format	article
author	Junying Sun Baocun Sun Ran Sun Dongwang Zhu Xiulan Zhao Yanhui Zhang Xueyi Dong Na Che Jing Li Fang Liu Nan Zhao Yong Wang Danfang Zhang
author_facet	Junying Sun Baocun Sun Ran Sun Dongwang Zhu Xiulan Zhao Yanhui Zhang Xueyi Dong Na Che Jing Li Fang Liu Nan Zhao Yong Wang Danfang Zhang
author_sort	Junying Sun
title	HMGA2 promotes vasculogenic mimicry and tumor aggressiveness by upregulating Twist1 in gastric carcinoma
title_short	HMGA2 promotes vasculogenic mimicry and tumor aggressiveness by upregulating Twist1 in gastric carcinoma
title_full	HMGA2 promotes vasculogenic mimicry and tumor aggressiveness by upregulating Twist1 in gastric carcinoma
title_fullStr	HMGA2 promotes vasculogenic mimicry and tumor aggressiveness by upregulating Twist1 in gastric carcinoma
title_full_unstemmed	HMGA2 promotes vasculogenic mimicry and tumor aggressiveness by upregulating Twist1 in gastric carcinoma
title_sort	hmga2 promotes vasculogenic mimicry and tumor aggressiveness by upregulating twist1 in gastric carcinoma
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/25a02bb7c79c4b7284c4da67e5884972
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HMGA2 promotes vasculogenic mimicry and tumor aggressiveness by upregulating Twist1 in gastric carcinoma

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